Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9344 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil |
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Silva, Maria LuizaAzevedo, Ana Carolina CampiBatista, Mauricio AzevedoMartins, Marina AngelaAvelar, Renato SathlerLemos, Denise da SilveiraCamacho, Luiz Antonio BastosMartins, Reinaldo de MenezesMaia, Maria de Lourdes de SousaFarias, Roberto Henrique GuedesFreire, Marcos da SilvaGaller, RicardoHomma, AkiraRibeiro, Jose Geraldo LeiteLemos, Jandira Aparecida CamposMartins, Maria AuxiliadoraSantos, Silvana Maria EloiCarvalho, Andréa TeixeiraMartins Filho, Olindo Assis2015-01-08T11:35:53Z2015-01-08T11:35:53Z2011SILVA, Maria Luiza et al. Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody. J Infect Dis, vol. 204, n. 6, p. 873-883, 2011.0022-1899https://www.arca.fiocruz.br/handle/icict/934410.1093/infdis/jir439.engInfectious Diseases Society of AmericaCytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibodyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilUniversidade Federal de Ouro Preto. Ouro Preto, MG, BrasilFundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Bio-Manguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Bio-Manguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Bio-Manguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Bio-Manguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Bio-Manguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Bio-Manguinhos. Rio de Janeiro, RJ, BrasilSecretaria de Estado de Saúde de Minas Gerais. Belo Horizonte, MG, BrasilSecretaria de Estado de Saúde de Minas Gerais. Belo Horizonte, MG, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hospital das Clínicas. Ribeirão Preto, SP, BrasilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Propedêutica Complementar Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilBackground. The live attenuated yellow fever (YF) vaccines have been available for decades and are considered highly effective and one of the safest vaccines worldwide. Methods. The impact of YF-17DD-antigens recall on cytokine profiles of YF-17DD-vaccinated children were characterized using short-term cultures of whole blood samples and single-cell flow cytometry. This study enrolled seroconverters and nonseroconverters after primovaccination (PV-PRNT1 and PV-PRNT2), seroconverters after revaccination (RV-PRNT1), and unvaccinated volunteers (UV-PRNT2). Results. The analysis demonstrated in the PV-PRNT1 group a balanced involvement of pro-inflammatory/ regulatory adaptive immunity with a prominent participation of innate immunity pro-inflammatory events (IL-121 and TNF-a1 NEU and MON). Using the PV-PRNT1 cytokine signature as a reference profile, PV-PRNT2 presented a striking lack of innate immunity proinflammatory response along with an increased adaptive regulatory profile (IL-41CD41 T cells and IL-101 and IL-51CD81 T cells). Conversely, the RV-PRNT1 shifted the overall cytokine signatures toward an innate immunity pro-inflammatory profile and restored the adaptive regulatory response. Conclusions. The data demonstrated that the overall cytokine signature was associated with the levels of PRNT antibodies with a balanced innate/adaptive immunity with proinflammatory/regulatory profile as the hallmark of PV-PRNTMEDIUM1, whereas a polarized regulatory response was observed in PV-PRNT2 and a prominent proinflammatory signature was the characteristic of PV-PRNTHIGH1.AntibodiesViral/bloodCytokines/secretionLeukocytesMononuclear/immunologyYellow Fever Vaccine/administration & dosageinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9344/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALCytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody.pdfCytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody.pdfapplication/pdf966125https://www.arca.fiocruz.br/bitstream/icict/9344/2/Cytokine%20Signatures%20of%20Innate%20and%20Adaptive%20Immunity%20in%2017DD%20Yellow%20Fever%20Vaccinated%20Children%20and%20Its%20Association%20With%20the%20Level%20of%20Neutralizing%20Antibody.pdf28568df442b4339a0d66df8a67105883MD52TEXTCytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody.pdf.txtCytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody.pdf.txtExtracted texttext/plain44506https://www.arca.fiocruz.br/bitstream/icict/9344/3/Cytokine%20Signatures%20of%20Innate%20and%20Adaptive%20Immunity%20in%2017DD%20Yellow%20Fever%20Vaccinated%20Children%20and%20Its%20Association%20With%20the%20Level%20of%20Neutralizing%20Antibody.pdf.txt6018c95feee66e669a7c7ffe8b1a1341MD53icict/93442019-06-19 10:07:33.093oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:07:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody |
| title |
Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody |
| spellingShingle |
Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody Silva, Maria Luiza Antibodies Viral/blood Cytokines/secretion Leukocytes Mononuclear/immunology Yellow Fever Vaccine/administration & dosage |
| title_short |
Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody |
| title_full |
Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody |
| title_fullStr |
Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody |
| title_full_unstemmed |
Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody |
| title_sort |
Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody |
| author |
Silva, Maria Luiza |
| author_facet |
Silva, Maria Luiza Azevedo, Ana Carolina Campi Batista, Mauricio Azevedo Martins, Marina Angela Avelar, Renato Sathler Lemos, Denise da Silveira Camacho, Luiz Antonio Bastos Martins, Reinaldo de Menezes Maia, Maria de Lourdes de Sousa Farias, Roberto Henrique Guedes Freire, Marcos da Silva Galler, Ricardo Homma, Akira Ribeiro, Jose Geraldo Leite Lemos, Jandira Aparecida Campos Martins, Maria Auxiliadora Santos, Silvana Maria Eloi Carvalho, Andréa Teixeira Martins Filho, Olindo Assis |
| author_role |
author |
| author2 |
Azevedo, Ana Carolina Campi Batista, Mauricio Azevedo Martins, Marina Angela Avelar, Renato Sathler Lemos, Denise da Silveira Camacho, Luiz Antonio Bastos Martins, Reinaldo de Menezes Maia, Maria de Lourdes de Sousa Farias, Roberto Henrique Guedes Freire, Marcos da Silva Galler, Ricardo Homma, Akira Ribeiro, Jose Geraldo Leite Lemos, Jandira Aparecida Campos Martins, Maria Auxiliadora Santos, Silvana Maria Eloi Carvalho, Andréa Teixeira Martins Filho, Olindo Assis |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Maria Luiza Azevedo, Ana Carolina Campi Batista, Mauricio Azevedo Martins, Marina Angela Avelar, Renato Sathler Lemos, Denise da Silveira Camacho, Luiz Antonio Bastos Martins, Reinaldo de Menezes Maia, Maria de Lourdes de Sousa Farias, Roberto Henrique Guedes Freire, Marcos da Silva Galler, Ricardo Homma, Akira Ribeiro, Jose Geraldo Leite Lemos, Jandira Aparecida Campos Martins, Maria Auxiliadora Santos, Silvana Maria Eloi Carvalho, Andréa Teixeira Martins Filho, Olindo Assis |
| dc.subject.en.pt_BR.fl_str_mv |
Antibodies Viral/blood Cytokines/secretion Leukocytes Mononuclear/immunology Yellow Fever Vaccine/administration & dosage |
| topic |
Antibodies Viral/blood Cytokines/secretion Leukocytes Mononuclear/immunology Yellow Fever Vaccine/administration & dosage |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil |
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2011 |
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2011 |
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2015-01-08T11:35:53Z |
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2015-01-08T11:35:53Z |
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info:eu-repo/semantics/article |
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SILVA, Maria Luiza et al. Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody. J Infect Dis, vol. 204, n. 6, p. 873-883, 2011. |
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https://www.arca.fiocruz.br/handle/icict/9344 |
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0022-1899 |
| dc.identifier.doi.none.fl_str_mv |
10.1093/infdis/jir439. |
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SILVA, Maria Luiza et al. Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody. J Infect Dis, vol. 204, n. 6, p. 873-883, 2011. 0022-1899 10.1093/infdis/jir439. |
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Infectious Diseases Society of America |
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Infectious Diseases Society of America |
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