Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil.

Detalhes bibliográficos
Autor(a) principal: Caldas, Arlene de Jesus Mendes
Data de Publicação: 2002
Outros Autores: Costa, Jackson Mauricio Lopes, Silva, Antonio Augusto Moura da, Vinhas, Vera Silvia de Freitas, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9165
Resumo: Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luis, MA, Brasil
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spelling Caldas, Arlene de Jesus MendesCosta, Jackson Mauricio LopesSilva, Antonio Augusto Moura daVinhas, Vera Silvia de FreitasBarral, Aldina Maria Prado2014-12-12T13:23:21Z2014-12-12T13:23:21Z2002CALDAS, A. J. M. et al. Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 96, n. 1, p. 21-28, 2002.0035-9203https://www.arca.fiocruz.br/handle/icict/9165engOxford University PressRisk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luis, MA, BrasilFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luis, MA, BrasilFederal University of Maranhão. Public Health Department. São Luis, MA, BrasilFederal University of Bahia. School of Medicine. Immunology Service. Salvador, BA, BrasilFederal University of Bahia. School of Medicine. Immunology Service. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilVarious factors have been associated with a predisposition to the development of clinical American visceral leishmaniasis (AVL). However, little information is available about the factors that predispose to asymptomatic infection. To identify the risk factors associated with asymptomatic infection, a study was carried out between July 1997 and June 1998 on children aged 0-5 years in the districts of Vila Nova and Bom Viver in the municipality of Raposa in the island of São Luís, State of Maranhão, Brazil. A questionnaire containing socioeconomic, demographic and epidemiological data was used. The delayed-type hypersensitivity (DTH) test was carried out on 639 children in the first phase, and on 572 in the second, 7 months after the first survey, using Leishmania amazonensis antigen. Infection was determined by enzyme-linked immunosorbent assay (ELISA) in 638 children during the first phase, and in 572 during the second. Six outcome measures were used: initial prevalence, final prevalence and incidence, each determined by DTH and ELISA. The incidence of infection was 10.8% when determined by DTH and 28.5% when determined by ELISA. After adjustment for confounding variables using Cox regression, infection by L. chagasi was associated with child's age (> or = 2 years), location of the dwellings (Vila Nova) and reporting of relatives with AVL. Bathing outside the house and playing outdoors between 18:00 and 20:00 were identified as risk factors in some analyses but not in others. Presence of intra- and peridomestic Lutzomyia sandflies and animals such as dogs or chickens in the house or in the neighbourhood appeared as risk factors in some analyses but in others they unexpectedly seemed to protect from infection. Malnutrition was not found to be associated with infection.Visceral leishmaniasisLeishmania chagasiAsymptomatic infectionChildrenPrevalenceIncidenceRisk factorsBrazilLeishmania infantumLeishmaniose Visceral/epidemiologiaAnimaisBrasil/epidemiologiaPré-EscolarEnsaio de Imunoadsorção EnzimáticaFemininoHumanosHipersensibilidade Tardia/epidemiologiaIncidênciaLactenteRecém-NascidoMasculinoPrevalênciaEstudos ProspectivosFatores de riscoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9165/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALCaldas A J M Risk factors....pdfCaldas A J M Risk factors....pdfapplication/pdf898418https://www.arca.fiocruz.br/bitstream/icict/9165/2/Caldas%20A%20J%20M%20Risk%20factors....pdfdc1f0bac263e1c43111433454490ad38MD52TEXTCaldas A J M Risk factors....pdf.txtCaldas A J M Risk factors....pdf.txtExtracted texttext/plain44263https://www.arca.fiocruz.br/bitstream/icict/9165/3/Caldas%20A%20J%20M%20Risk%20factors....pdf.txt47ac3620193587098d21a0cfc7a3e7deMD53icict/91652023-03-15 14:33:03.122oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil.
title Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil.
spellingShingle Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil.
Caldas, Arlene de Jesus Mendes
Visceral leishmaniasis
Leishmania chagasi
Asymptomatic infection
Children
Prevalence
Incidence
Risk factors
Brazil
Leishmania infantum
Leishmaniose Visceral/epidemiologia
Animais
Brasil/epidemiologia
Pré-Escolar
Ensaio de Imunoadsorção Enzimática
Feminino
Humanos
Hipersensibilidade Tardia/epidemiologia
Incidência
Lactente
Recém-Nascido
Masculino
Prevalência
Estudos Prospectivos
Fatores de risco
title_short Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil.
title_full Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil.
title_fullStr Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil.
title_full_unstemmed Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil.
title_sort Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil.
author Caldas, Arlene de Jesus Mendes
author_facet Caldas, Arlene de Jesus Mendes
Costa, Jackson Mauricio Lopes
Silva, Antonio Augusto Moura da
Vinhas, Vera Silvia de Freitas
Barral, Aldina Maria Prado
author_role author
author2 Costa, Jackson Mauricio Lopes
Silva, Antonio Augusto Moura da
Vinhas, Vera Silvia de Freitas
Barral, Aldina Maria Prado
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Caldas, Arlene de Jesus Mendes
Costa, Jackson Mauricio Lopes
Silva, Antonio Augusto Moura da
Vinhas, Vera Silvia de Freitas
Barral, Aldina Maria Prado
dc.subject.en.pt_BR.fl_str_mv Visceral leishmaniasis
Leishmania chagasi
Asymptomatic infection
Children
Prevalence
Incidence
Risk factors
Brazil
topic Visceral leishmaniasis
Leishmania chagasi
Asymptomatic infection
Children
Prevalence
Incidence
Risk factors
Brazil
Leishmania infantum
Leishmaniose Visceral/epidemiologia
Animais
Brasil/epidemiologia
Pré-Escolar
Ensaio de Imunoadsorção Enzimática
Feminino
Humanos
Hipersensibilidade Tardia/epidemiologia
Incidência
Lactente
Recém-Nascido
Masculino
Prevalência
Estudos Prospectivos
Fatores de risco
dc.subject.decs.pt_BR.fl_str_mv Leishmania infantum
Leishmaniose Visceral/epidemiologia
Animais
Brasil/epidemiologia
Pré-Escolar
Ensaio de Imunoadsorção Enzimática
Feminino
Humanos
Hipersensibilidade Tardia/epidemiologia
Incidência
Lactente
Recém-Nascido
Masculino
Prevalência
Estudos Prospectivos
Fatores de risco
description Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luis, MA, Brasil
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2014-12-12T13:23:21Z
dc.date.available.fl_str_mv 2014-12-12T13:23:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CALDAS, A. J. M. et al. Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 96, n. 1, p. 21-28, 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9165
dc.identifier.issn.none.fl_str_mv 0035-9203
identifier_str_mv CALDAS, A. J. M. et al. Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 96, n. 1, p. 21-28, 2002.
0035-9203
url https://www.arca.fiocruz.br/handle/icict/9165
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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