Action of natural products on p2 receptors: a reinvented era for drug discovery

Detalhes bibliográficos
Autor(a) principal: Faria, Robson
Data de Publicação: 2012
Outros Autores: Ferreira, Leonardo, Bezerra, Rômulo, Frutuoso, Valber, Alves, Luiz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15352
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
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spelling Faria, RobsonFerreira, LeonardoBezerra, RômuloFrutuoso, ValberAlves, Luiz2016-08-23T17:21:15Z2016-08-23T17:21:15Z2012FARIA, Robson; et al. Action of natural products on p2 receptors: a reinvented era for drug discovery. Molecules, v.17, n.11, p.13009-13025, Nov. 2012.1420-3049https://www.arca.fiocruz.br/handle/icict/1535210.3390/molecules171113009engMDPIProdutos BiológicosAntagonistasreceptores P2Preparações FarmacêuticasP2 receptorsNatural productsAntagonistsDrugsAction of natural products on p2 receptors: a reinvented era for drug discoveryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives to synthetic drugs. With several diseases such as cancer, and inflammatory and neuropathic diseases having been linked to the participation of purinergic (P2) receptors, there has been a flurry of investigations on ligands within natural products. Thirty-four different sources of these compounds have been found so far, that have shown either agonistic or antagonistic effects on P2 receptors. Of those, nine different plant sources demonstrated effects on P2X2, P2X3, P2X7, and possibly P2Y12 receptor subtypes. Microorganisms, which represent the largest group, with 26 different sources, showed effects on both receptor subtypes, ranging from P2X1 to P2X4 and P2X7, and P2Y1, P2Y2, P2Y4, and P2Y6. In addition, there were seventeen animal sources that affected P2X7 and P2Y1 and P2Y12 receptors. Natural products have provided some fascinating new mechanisms and sources to better understand the P2 receptor antagonism. Moreover, current investigations should clarify further pharmacological mechanisms in order to consider these products as potential new medicines.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15352/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALrobson_faria_etal_IOC_2012.pdfrobson_faria_etal_IOC_2012.pdfapplication/pdf223930https://www.arca.fiocruz.br/bitstream/icict/15352/2/robson_faria_etal_IOC_2012.pdf88f22e67c64c337b2b670b68ce2c31fbMD52TEXTrobson_faria_etal_IOC_2012.pdf.txtrobson_faria_etal_IOC_2012.pdf.txtExtracted texttext/plain54553https://www.arca.fiocruz.br/bitstream/icict/15352/3/robson_faria_etal_IOC_2012.pdf.txta11c070f4bb26359b1f21e83ecbac960MD53icict/153522018-04-02 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dc.title.pt_BR.fl_str_mv Action of natural products on p2 receptors: a reinvented era for drug discovery
title Action of natural products on p2 receptors: a reinvented era for drug discovery
spellingShingle Action of natural products on p2 receptors: a reinvented era for drug discovery
Faria, Robson
Produtos Biológicos
Antagonistas
receptores P2
Preparações Farmacêuticas
P2 receptors
Natural products
Antagonists
Drugs
title_short Action of natural products on p2 receptors: a reinvented era for drug discovery
title_full Action of natural products on p2 receptors: a reinvented era for drug discovery
title_fullStr Action of natural products on p2 receptors: a reinvented era for drug discovery
title_full_unstemmed Action of natural products on p2 receptors: a reinvented era for drug discovery
title_sort Action of natural products on p2 receptors: a reinvented era for drug discovery
author Faria, Robson
author_facet Faria, Robson
Ferreira, Leonardo
Bezerra, Rômulo
Frutuoso, Valber
Alves, Luiz
author_role author
author2 Ferreira, Leonardo
Bezerra, Rômulo
Frutuoso, Valber
Alves, Luiz
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Faria, Robson
Ferreira, Leonardo
Bezerra, Rômulo
Frutuoso, Valber
Alves, Luiz
dc.subject.other.pt_BR.fl_str_mv Produtos Biológicos
Antagonistas
receptores P2
Preparações Farmacêuticas
topic Produtos Biológicos
Antagonistas
receptores P2
Preparações Farmacêuticas
P2 receptors
Natural products
Antagonists
Drugs
dc.subject.en.pt_BR.fl_str_mv P2 receptors
Natural products
Antagonists
Drugs
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-08-23T17:21:15Z
dc.date.available.fl_str_mv 2016-08-23T17:21:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FARIA, Robson; et al. Action of natural products on p2 receptors: a reinvented era for drug discovery. Molecules, v.17, n.11, p.13009-13025, Nov. 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15352
dc.identifier.issn.pt_BR.fl_str_mv 1420-3049
dc.identifier.doi.none.fl_str_mv 10.3390/molecules171113009
identifier_str_mv FARIA, Robson; et al. Action of natural products on p2 receptors: a reinvented era for drug discovery. Molecules, v.17, n.11, p.13009-13025, Nov. 2012.
1420-3049
10.3390/molecules171113009
url https://www.arca.fiocruz.br/handle/icict/15352
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15352/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/15352/2/robson_faria_etal_IOC_2012.pdf
https://www.arca.fiocruz.br/bitstream/icict/15352/3/robson_faria_etal_IOC_2012.pdf.txt
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