Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?

Mashally, Sally; Banihani, Rudaina; Jasani, Bonny; Nield, Lynne E.; Martins, Fernando F.; Jain, Amish; Weisz, Dany E.

Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?

Detalhes bibliográficos
Autor(a) principal:	Mashally, Sally
Data de Publicação:	2021
Outros Autores:	Banihani, Rudaina, Jasani, Bonny, Nield, Lynne E., Martins, Fernando F., Jain, Amish, Weisz, Dany E.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/49309
Resumo:	The online version contains supplementary material available at 10.1038/s41372-021-01194-4.

Metadados do item

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spelling	Mashally, SallyBanihani, RudainaJasani, BonnyNield, Lynne E.Martins, Fernando F.Jain, AmishWeisz, Dany E.2021-10-07T12:28:58Z2021-10-07T12:28:58Z2021MASHALLY, Sally et al. Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus? Journal of Perinatology, p. 1-7, 27 Aug. 2021.0743-8346https://www.arca.fiocruz.br/handle/icict/4930910.1038/s41372-021-01194-4The online version contains supplementary material available at 10.1038/s41372-021-01194-4.Sunnybrook Health Sciences Centre. Department of Newborn and Developmental Pediatrics. Toronto, ON, Canada.Sunnybrook Health Sciences Centre. Department of Newborn and Developmental Pediatrics. Toronto, ON, Canada / University of Toronto. Department of Pediatrics. Toronto, ON, Canada.University of Toronto. Department of Pediatrics. Toronto, ON, Canada / Hospital for Sick Children. Division of Neonatology. Department of Pediatrics. Toronto, ON, Canada.Sunnybrook Health Sciences Centre. Department of Newborn and Developmental Pediatrics. Toronto, ON, Canada / University of Toronto. Department of Pediatrics. Toronto, ON, Canada / Hospital for Sick Children. Division of Neonatology. Department of Pediatrics. Toronto, ON, Canada.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Neonatologia. Rio de Janeiro, RJ, Brasil.University of Toronto. Department of Pediatrics. Toronto, ON, Canada / Mt. Sinai Hospital. Department of Pediatrics. Toronto, ON, Canada.Sunnybrook Health Sciences Centre. Department of Newborn and Developmental Pediatrics. Toronto, ON, Canada / University of Toronto. Department of Pediatrics. Toronto, ON, Canada.Objective: Evaluate the association of late treatment with acetaminophen vs. immediate surgical ligation with death or neurodevelopmental impairment (NDI) among extremely low gestational age neonates (ELGANs) with persistent patent ductus arteriosus (pPDA). Study design: Retrospective comparative epoch study of ELGANs with pPDA being considered for surgical ligation. ELGANs in epoch 1 (2009-2012) were referred for ligation, while infants in epoch 2 (2012-2015) were treated with oral acetaminophen and referred for ligation in the absence of improvement. The primary outcome was a composite of death/NDI at 18-24 months. Results: Ninety-two ELGANs with median[IQR] GA 25.2 weeks [24.4, 26.3] had pPDA (43 in epoch 1, 49 in -epoch 2) with acetaminophen-exposed neonates receiving 7 days [7, 7] of treatment. ELGANs in epoch 2 had reduced ligation (aOR 0.30; 95%CI: [0.11, 0.87]), but there was no difference in death/NDI (aOR 1.03; 95%CI: [0.30, 3.56]). Conclusions: Late treatment with acetaminophen to avoid surgery for pPDA is associated with reduced ligation but no difference in death/NDI, supporting the safety and effectiveness of this approach.engSpringer NatureIs late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCongenital heart defectsPaediatricsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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2application/vnd.openxmlformats-officedocument.wordprocessingml.document16142https://www.arca.fiocruz.br/bitstream/icict/49309/4/41372_2021_1194_MOESM2_ESM.docx235ea54dd2dcca2da12e4244416a914bMD5441372_2021_1194_MOESM3_ESM.docx41372_2021_1194_MOESM3_ESM.docxSupplementary Information - Supplementary Table 3application/vnd.openxmlformats-officedocument.wordprocessingml.document14555https://www.arca.fiocruz.br/bitstream/icict/49309/5/41372_2021_1194_MOESM3_ESM.docx045bf10f5f4da04594929476dd3c3f50MD55icict/493092021-10-07 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dc.title.en.fl_str_mv	Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?
title	Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?
spellingShingle	Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus? Mashally, Sally Congenital heart defects Paediatrics
title_short	Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?
title_full	Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?
title_fullStr	Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?
title_full_unstemmed	Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?
title_sort	Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?
author	Mashally, Sally
author_facet	Mashally, Sally Banihani, Rudaina Jasani, Bonny Nield, Lynne E. Martins, Fernando F. Jain, Amish Weisz, Dany E.
author_role	author
author2	Banihani, Rudaina Jasani, Bonny Nield, Lynne E. Martins, Fernando F. Jain, Amish Weisz, Dany E.
author2_role	author author author author author author
dc.contributor.author.fl_str_mv	Mashally, Sally Banihani, Rudaina Jasani, Bonny Nield, Lynne E. Martins, Fernando F. Jain, Amish Weisz, Dany E.
dc.subject.en.pt_BR.fl_str_mv	Congenital heart defects Paediatrics
topic	Congenital heart defects Paediatrics
description	The online version contains supplementary material available at 10.1038/s41372-021-01194-4.
publishDate	2021
dc.date.accessioned.fl_str_mv	2021-10-07T12:28:58Z
dc.date.available.fl_str_mv	2021-10-07T12:28:58Z
dc.date.issued.fl_str_mv	2021
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	MASHALLY, Sally et al. Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus? Journal of Perinatology, p. 1-7, 27 Aug. 2021.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/49309
dc.identifier.issn.pt_BR.fl_str_mv	0743-8346
dc.identifier.doi.pt_BR.fl_str_mv	10.1038/s41372-021-01194-4
identifier_str_mv	MASHALLY, Sally et al. Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus? Journal of Perinatology, p. 1-7, 27 Aug. 2021. 0743-8346 10.1038/s41372-021-01194-4
url	https://www.arca.fiocruz.br/handle/icict/49309
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Springer Nature
publisher.none.fl_str_mv	Springer Nature
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/49309/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/49309/2/ve_Fernando_Martins_etal_IFF_2021.pdf https://www.arca.fiocruz.br/bitstream/icict/49309/3/41372_2021_1194_MOESM1_ESM.docx https://www.arca.fiocruz.br/bitstream/icict/49309/4/41372_2021_1194_MOESM2_ESM.docx https://www.arca.fiocruz.br/bitstream/icict/49309/5/41372_2021_1194_MOESM3_ESM.docx
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Is late treatment with acetaminophen safe and effective in avoiding surgical ligation among extremely preterm neonates with persistent patent ductus arteriosus?

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