Evaluating the care cascade after antiretroviral therapy initiation in Latin America

Detalhes bibliográficos
Autor(a) principal: Wolff, Marcelo J.
Data de Publicação: 2018
Outros Autores: Cortes, Claudia P., Mejìa, Fernando A., Padgett, Denis, Belaunzarán-Zamudio, Pablo, Grinsztejn, Beatriz, Giganti, Mark J., McGowan, Catherine C., Rebeiro, Peter F
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25473
Resumo: 2019-01-31
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spelling Wolff, Marcelo J.Cortes, Claudia P.Mejìa, Fernando A.Padgett, DenisBelaunzarán-Zamudio, PabloGrinsztejn, BeatrizGiganti, Mark J.McGowan, Catherine C.Rebeiro, Peter F2018-03-23T15:06:28Z2018-03-23T15:06:28Z2018WOLFF, Marcelo J. et al. Evaluating the care cascade after antiretroviral therapy initiation in Latin America. International Journal of STD and AIDS, v. 29, n. 1, p. 4-12, Jan. 2018.0956-4624https://www.arca.fiocruz.br/handle/icict/2547310.1177/0956462417714094engSAGEEvaluating the care cascade after antiretroviral therapy initiation in Latin Americainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2019-01-31University of Chile. Fundacion Arriaran. School of Medicine. Santiago, Chile.University of Chile. Fundacion Arriaran. School of Medicine. Santiago, Chile.Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Peru.Instituto Hondureño de Seguridad Social and Hospital Escuela Universitario. Tegucigalpa, Honduras.Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City, Mexico / Universidad Nacional Autónoma de México. División de Investigación de Facultad de Medicina. Mexico City, Mexico.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brasil.Vanderbilt University School of Medicine. Nashville, TN, USA.Vanderbilt University School of Medicine. Nashville, TN, USA.Vanderbilt University School of Medicine. Nashville, TN, USA.Accelerating antiretroviral therapy (ART) administration, improving retention, and achieving viral suppression in low- and middle-income countries must be prioritized. We evaluated trends and disparities in these milestones in a large Latin American cohort. Adults starting ART (ARTstart) from 2003 to 2014 at Caribbean, Central, and South America network for HIV epidemiology sites were assessed for care cascade outcomes: CD4 cell count >200 cells/mm3at ARTstart; retention (≥1 visit at one year after ARTstart); viral suppression (≥1 HIV-1 RNA <200 copies/ml at one year after ARTstart). Modified Poisson regression provided adjusted prevalence ratios by age, gender, and HIV transmission risk, accounting for site and year of ARTstart. Proportions achieving ARTstartand suppression improved over time (p < 0.05). Older age was associated with better retention and viral suppression, but not ARTstartat CD4 cell count >200 cells/mm3. Females and men who have sex with men (MSM) were more likely to have CD4 cell count >200 cells/mm3at ARTstart. Injection drug users (IDUs) were less likely to be retained while MSM were more likely to achieve viral suppression (all p < 0.05). Despite improvements in these outcomes over the course of a decade in this cohort, significant disparities existed, disadvantaging younger patients, men, and IDUs. These gaps indicate continued progress in providing early diagnosis and ARTstartremain critical.HIVSouth AmericaAIDSEpidemiologyARTHomosexualMinorias SexuaisSíndrome de Imunodeficiência AdquiridaEpidemiologiaAmérica do Sulinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/25473/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALEvaluating the care cascade after antiretroviral therapy initiation in Latin America.pdfEvaluating the care cascade after antiretroviral therapy initiation in Latin America.pdfapplication/pdf342070https://www.arca.fiocruz.br/bitstream/icict/25473/2/Evaluating%20the%20care%20cascade%20after%20antiretroviral%20therapy%20initiation%20in%20Latin%20America.pdfd6bd7a5822fc1e4904815f6a46add746MD52TEXTEvaluating the care cascade after antiretroviral therapy initiation in 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dc.title.pt_BR.fl_str_mv Evaluating the care cascade after antiretroviral therapy initiation in Latin America
title Evaluating the care cascade after antiretroviral therapy initiation in Latin America
spellingShingle Evaluating the care cascade after antiretroviral therapy initiation in Latin America
Wolff, Marcelo J.
HIV
South America
AIDS
Epidemiology
ART
Homosexual
Minorias Sexuais
Síndrome de Imunodeficiência Adquirida
Epidemiologia
América do Sul
title_short Evaluating the care cascade after antiretroviral therapy initiation in Latin America
title_full Evaluating the care cascade after antiretroviral therapy initiation in Latin America
title_fullStr Evaluating the care cascade after antiretroviral therapy initiation in Latin America
title_full_unstemmed Evaluating the care cascade after antiretroviral therapy initiation in Latin America
title_sort Evaluating the care cascade after antiretroviral therapy initiation in Latin America
author Wolff, Marcelo J.
author_facet Wolff, Marcelo J.
Cortes, Claudia P.
Mejìa, Fernando A.
Padgett, Denis
Belaunzarán-Zamudio, Pablo
Grinsztejn, Beatriz
Giganti, Mark J.
McGowan, Catherine C.
Rebeiro, Peter F
author_role author
author2 Cortes, Claudia P.
Mejìa, Fernando A.
Padgett, Denis
Belaunzarán-Zamudio, Pablo
Grinsztejn, Beatriz
Giganti, Mark J.
McGowan, Catherine C.
Rebeiro, Peter F
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Wolff, Marcelo J.
Cortes, Claudia P.
Mejìa, Fernando A.
Padgett, Denis
Belaunzarán-Zamudio, Pablo
Grinsztejn, Beatriz
Giganti, Mark J.
McGowan, Catherine C.
Rebeiro, Peter F
dc.subject.en.pt_BR.fl_str_mv HIV
South America
AIDS
Epidemiology
ART
Homosexual
topic HIV
South America
AIDS
Epidemiology
ART
Homosexual
Minorias Sexuais
Síndrome de Imunodeficiência Adquirida
Epidemiologia
América do Sul
dc.subject.decs.pt_BR.fl_str_mv Minorias Sexuais
Síndrome de Imunodeficiência Adquirida
Epidemiologia
América do Sul
description 2019-01-31
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-03-23T15:06:28Z
dc.date.available.fl_str_mv 2018-03-23T15:06:28Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv WOLFF, Marcelo J. et al. Evaluating the care cascade after antiretroviral therapy initiation in Latin America. International Journal of STD and AIDS, v. 29, n. 1, p. 4-12, Jan. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25473
dc.identifier.issn.pt_BR.fl_str_mv 0956-4624
dc.identifier.doi.pt_BR.fl_str_mv 10.1177/0956462417714094
identifier_str_mv WOLFF, Marcelo J. et al. Evaluating the care cascade after antiretroviral therapy initiation in Latin America. International Journal of STD and AIDS, v. 29, n. 1, p. 4-12, Jan. 2018.
0956-4624
10.1177/0956462417714094
url https://www.arca.fiocruz.br/handle/icict/25473
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv SAGE
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
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