The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study

Detalhes bibliográficos
Autor(a) principal: Kahn, Rebecca
Data de Publicação: 2023
Outros Autores: Janusz, Cara B., Castro, Marcia C., Matos, Aline da Rocha, Domingues, Carla, Ponmattam, Jamie, Rey-Benito, Gloria, Toscano, Cristiana M., Oliveira, Lucia Helena de, Regional COVID-19 VE in Adults Study Working Group
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58743
Resumo: Funding This study was funded by the Pan-American Health Organization (PAHO, World Health Organization (WHO)). PAHO convened and led the study implementation.
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spelling Kahn, RebeccaJanusz, Cara B.Castro, Marcia C.Matos, Aline da RochaDomingues, CarlaPonmattam, JamieRey-Benito, GloriaToscano, Cristiana M.Oliveira, Lucia Helena deRegional COVID-19 VE in Adults Study Working Group2023-05-26T14:09:08Z2023-05-26T14:09:08Z2023KHAN, Rebecca et al. The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study. The Lancet Regional Health - Americas. v.20: 100474, p. 1 - 12, 2023.2667-193Xhttps://www.arca.fiocruz.br/handle/icict/5874310. 1016/j.lana.2023. 100474Funding This study was funded by the Pan-American Health Organization (PAHO, World Health Organization (WHO)). PAHO convened and led the study implementation.Harvard TH Chan School of Public Health, 677 Huntington Ave Suite 506, Boston, MA, 02115, USA.University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.Harvard TH Chan School of Public Health. Boston, MA, 02115, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais. Rio de Janeiro, RJ, Brasil.SMDB conjunto 12b lote 3 Casa B. Brasília DF, Brasil.Harvard TH Chan School of Public Health. Boston, MA, 02115, USA.Immunization Unit, Pan American Health Organization, Washington, USA.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Immunization Unit, Pan American Health Organization, Washington, USA.Summary Background As of September 2022, nearly 1.3 billion doses of COVID-19 vaccine products have been administered in Latin America and the Caribbean, where 27% of global COVID-19 deaths have occurred. This study aimed to estimate the effectiveness of COVID-19 vaccines against lab-confirmed COVID-19 related hospitalizations and deaths among adults in Argentina, Brazil, Chile, and Colombia. Methods Using a test-negative case control design, we evaluated the effectiveness of a primary vaccination series considering six COVID-19 vaccine products (Sputnik V, mRNA-1273, CoronaVac, ChAdOx1, BNT162b2, Ad26.COV2.S) against lab-confirmed COVID-19 hospitalizations and deaths among 83,708 hospitalized adults from February–December, 2021. Data from hospitalization records, COVID surveillance, and vaccination registries were used. Vaccine effectiveness was estimated using logistic regression ((1-OR) x 100). Findings The average age of participants was 56.7 (SD = 17.5), and 45,894 (54.8%) were male. Adjusted VE (aVE) estimates for full vaccination against hospitalization were 82% for mRNA-1273 (95% confidence interval (CI) = −30 to 98%), 76% (71%–81%) for BNT162b2, 65% (61–68%) for ChAdOx1, 57% (10–79%) for Sputnik V, 53% (50–56%) for CoronaVac, and 46% (23–62%) for Ad26.COV2.S. Estimates, particularly for CoronaVac, varied by variant. Decreasing aVE was estimated as age increased, particularly for CoronaVac and ChAdOx1. aVE estimates against death were generally higher, with 100% (CI not estimated) for mRNA-1273, 82% (69–90%) for BNT162b2, 73% (69–77%) for ChAdOx1, 65% (60–67%) for CoronaVac, 38% (−75 to 78%) for Sputnik V, 6% (−58 to 44%) for Ad26.COV2.S.engElsevier Ltd.Vacinação COVID-19Eficácia da vacinaControle de casoTeste negativoBrasilChileArgentinaColômbiaCOVID-19 vaccinationVaccine effectivenessCase–controlTest-negativeBrazilChileArgentinaColombiaThe effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study
title The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study
spellingShingle The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study
Kahn, Rebecca
Vacinação COVID-19
Eficácia da vacina
Controle de caso
Teste negativo
Brasil
Chile
Argentina
Colômbia
COVID-19 vaccination
Vaccine effectiveness
Case–control
Test-negative
Brazil
Chile
Argentina
Colombia
title_short The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study
title_full The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study
title_fullStr The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study
title_full_unstemmed The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study
title_sort The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study
author Kahn, Rebecca
author_facet Kahn, Rebecca
Janusz, Cara B.
Castro, Marcia C.
Matos, Aline da Rocha
Domingues, Carla
Ponmattam, Jamie
Rey-Benito, Gloria
Toscano, Cristiana M.
Oliveira, Lucia Helena de
Regional COVID-19 VE in Adults Study Working Group
author_role author
author2 Janusz, Cara B.
Castro, Marcia C.
Matos, Aline da Rocha
Domingues, Carla
Ponmattam, Jamie
Rey-Benito, Gloria
Toscano, Cristiana M.
Oliveira, Lucia Helena de
Regional COVID-19 VE in Adults Study Working Group
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kahn, Rebecca
Janusz, Cara B.
Castro, Marcia C.
Matos, Aline da Rocha
Domingues, Carla
Ponmattam, Jamie
Rey-Benito, Gloria
Toscano, Cristiana M.
Oliveira, Lucia Helena de
Regional COVID-19 VE in Adults Study Working Group
dc.subject.other.en_US.fl_str_mv Vacinação COVID-19
Eficácia da vacina
Controle de caso
Teste negativo
Brasil
Chile
Argentina
Colômbia
topic Vacinação COVID-19
Eficácia da vacina
Controle de caso
Teste negativo
Brasil
Chile
Argentina
Colômbia
COVID-19 vaccination
Vaccine effectiveness
Case–control
Test-negative
Brazil
Chile
Argentina
Colombia
dc.subject.en.en_US.fl_str_mv COVID-19 vaccination
Vaccine effectiveness
Case–control
Test-negative
Brazil
Chile
Argentina
Colombia
description Funding This study was funded by the Pan-American Health Organization (PAHO, World Health Organization (WHO)). PAHO convened and led the study implementation.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-26T14:09:08Z
dc.date.available.fl_str_mv 2023-05-26T14:09:08Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KHAN, Rebecca et al. The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study. The Lancet Regional Health - Americas. v.20: 100474, p. 1 - 12, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58743
dc.identifier.issn.en_US.fl_str_mv 2667-193X
dc.identifier.doi.none.fl_str_mv 10. 1016/j.lana.2023. 100474
identifier_str_mv KHAN, Rebecca et al. The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study. The Lancet Regional Health - Americas. v.20: 100474, p. 1 - 12, 2023.
2667-193X
10. 1016/j.lana.2023. 100474
url https://www.arca.fiocruz.br/handle/icict/58743
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Ltd.
publisher.none.fl_str_mv Elsevier Ltd.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/58743/2/AlineMatos_RebecaKhan_etal_IOC_2023.pdf
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