Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls

Detalhes bibliográficos
Autor(a) principal: Galvão, Stanley de S. L.
Data de Publicação: 2016
Outros Autores: Monteiro, Andrea de S., Siqueira Filho, Ezequias Pessoa de, Bomfim, Maria Rosa Quaresma, Souza, Marcus Vinícius Dias, Ferreira, Gabriella F., Denadai, Angelo Márcio Leite, Santos, Áquila R. C., Santos, Vera Lúcia dos, Fagundes, Elaine M. de Souza, Fernandes, Elizabeth S., Monteiro Neto, Valério
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17815
Resumo: 2021-01-01
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spelling Galvão, Stanley de S. L.Monteiro, Andrea de S.Siqueira Filho, Ezequias Pessoa deBomfim, Maria Rosa QuaresmaSouza, Marcus Vinícius DiasFerreira, Gabriella F.Denadai, Angelo Márcio LeiteSantos, Áquila R. C.Santos, Vera Lúcia dosFagundes, Elaine M. de SouzaFernandes, Elizabeth S.Monteiro Neto, Valério2017-02-14T18:18:07Z2017-02-14T18:18:07Z2016GALVÃO, Stanley de S. L. et al. Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls. Front Microbiol, v. 7, art. 2053, 2016.https://www.arca.fiocruz.br/handle/icict/1781510.3389/fmicb.2016.020531664-302XengFrontiers Research FoundationAnnona glabraPseudomonas aeruginosaAnnona glabraPseudomonas aeruginosaantimicrobial activityflavonoidsAnnona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Wallsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2021-01-01Universidade CEUMA. Centro de Ciências da Saúde. São Luís, MA, BrazilUniversidade CEUMA. Centro de Ciências da Saúde. São Luís, MA, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrazilUniversidade CEUMA. Centro de Ciências da Saúde. São Luís, MA, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Juiz de Fora. Departamento de Farmácia. Governador Valadares, MG, BrazilUniversidade Federal de Juiz de Fora. Departamento de Farmácia. Governador Valadares, MG, BrazilUniversidade Federal de Juiz de Fora. Departamento de Farmácia. Governador Valadares, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Fisiologia e Biofisica. Belo Horizonte, MG,BrazilUniversidade CEUMA. Centro de Ciências da Saúde. São Luís, MA, BrazilUniversidade CEUMA. Centro de Ciências da Saúde. São Luís, MA, Brazil/Universidade Federal do Maranhão. Departamento de Patologia. São Luís, MG, BrazilPseudomonas aeruginosa is an important pathogen in opportunistic infections in humans. The increased incidence of antimicrobial-resistant P. aeruginosa isolates has highlighted the need for novel and more potent therapies against this microorganism. Annona glabra is known for presenting different compounds with diverse biological activities, such as anti-tumor and immunomodulatory activities. Although other species of the family display antimicrobial actions, this has not yet been reported for A. glabra. Here, we investigated the antimicrobial activity of the ethyl acetate fraction (EAF) obtained from the leaf hydroalcoholic extract of A. glabra. EAF was bactericidal against different strains of P. aeruginosa. EAF also presented with a time- and concentration-dependent effect on P. aeruginosa viability. Testing of different EAF sub-fractions showed that the sub-fraction 32-33 (SF32-33) was the most effective against P. aeruginosa. Analysis of the chemical constituents of SF32-33 demonstrated a high content of flavonoids. Incubation of this active sub-fraction with P. aeruginosa ATCC 27983 triggered an endothermic reaction, which was accompanied by an increased electric charge, suggesting a high binding of SF32-33 compounds to bacterial cell walls. Collectively, our results suggest that A. glabra-derived compounds, especially flavonoids, may be useful for treating infections caused by P. aeruginosa.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/17815/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALve_Galvão_Stanley_Annona glabra_CPqRR_2016.pdfve_Galvão_Stanley_Annona glabra_CPqRR_2016.pdfapplication/pdf289696https://www.arca.fiocruz.br/bitstream/icict/17815/2/ve_Galv%c3%a3o_Stanley_Annona%20glabra_CPqRR_2016.pdf1e6b1d7ad445c37d195e4a241503da82MD52TEXTve_Galvão_Stanley_Annona glabra_CPqRR_2016.pdf.txtve_Galvão_Stanley_Annona glabra_CPqRR_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls
title Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls
spellingShingle Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls
Galvão, Stanley de S. L.
Annona glabra
Pseudomonas aeruginosa
Annona glabra
Pseudomonas aeruginosa
antimicrobial activity
flavonoids
title_short Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls
title_full Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls
title_fullStr Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls
title_full_unstemmed Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls
title_sort Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls
author Galvão, Stanley de S. L.
author_facet Galvão, Stanley de S. L.
Monteiro, Andrea de S.
Siqueira Filho, Ezequias Pessoa de
Bomfim, Maria Rosa Quaresma
Souza, Marcus Vinícius Dias
Ferreira, Gabriella F.
Denadai, Angelo Márcio Leite
Santos, Áquila R. C.
Santos, Vera Lúcia dos
Fagundes, Elaine M. de Souza
Fernandes, Elizabeth S.
Monteiro Neto, Valério
author_role author
author2 Monteiro, Andrea de S.
Siqueira Filho, Ezequias Pessoa de
Bomfim, Maria Rosa Quaresma
Souza, Marcus Vinícius Dias
Ferreira, Gabriella F.
Denadai, Angelo Márcio Leite
Santos, Áquila R. C.
Santos, Vera Lúcia dos
Fagundes, Elaine M. de Souza
Fernandes, Elizabeth S.
Monteiro Neto, Valério
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Galvão, Stanley de S. L.
Monteiro, Andrea de S.
Siqueira Filho, Ezequias Pessoa de
Bomfim, Maria Rosa Quaresma
Souza, Marcus Vinícius Dias
Ferreira, Gabriella F.
Denadai, Angelo Márcio Leite
Santos, Áquila R. C.
Santos, Vera Lúcia dos
Fagundes, Elaine M. de Souza
Fernandes, Elizabeth S.
Monteiro Neto, Valério
dc.subject.other.pt_BR.fl_str_mv Annona glabra
Pseudomonas aeruginosa
topic Annona glabra
Pseudomonas aeruginosa
Annona glabra
Pseudomonas aeruginosa
antimicrobial activity
flavonoids
dc.subject.en.pt_BR.fl_str_mv Annona glabra
Pseudomonas aeruginosa
antimicrobial activity
flavonoids
description 2021-01-01
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-02-14T18:18:07Z
dc.date.available.fl_str_mv 2017-02-14T18:18:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GALVÃO, Stanley de S. L. et al. Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls. Front Microbiol, v. 7, art. 2053, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17815
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2016.02053
dc.identifier.eissn.none.fl_str_mv 1664-302X
identifier_str_mv GALVÃO, Stanley de S. L. et al. Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls. Front Microbiol, v. 7, art. 2053, 2016.
10.3389/fmicb.2016.02053
1664-302X
url https://www.arca.fiocruz.br/handle/icict/17815
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/17815/1/license.txt
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