Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era

Detalhes bibliográficos
Autor(a) principal: Sá, Ana Caroline C.
Data de Publicação: 2015
Outros Autores: Gómez, Mariela Martínez, Lima, Ila Fernanda N., Quetz, Josiane S., Havt, Alexandre, Oriá, Reinaldo B., Lima, Aldo A., Leite, José Paulo G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12000
Resumo: 2015-12-31
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spelling Sá, Ana Caroline C.Gómez, Mariela MartínezLima, Ila Fernanda N.Quetz, Josiane S.Havt, AlexandreOriá, Reinaldo B.Lima, Aldo A.Leite, José Paulo G.2015-10-20T14:42:30Z2016-01-01T06:30:05Z2015SÁ, Ana Caroline C. et al. Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era. Journal of Medical Virology, v.87, p.1480–1490, 2015.1096-9071https://www.arca.fiocruz.br/handle/icict/1200010.1002/jmvengWiley Periodicals Inc.Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Erainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2015-12-31Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Universidade Federal do Ceará. Instituto de Biomedicina para Semi-Árido Brasileiro. Unidade de Pesquisa Clínica. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Instituto de Biomedicina para Semi-Árido Brasileiro. Unidade de Pesquisa Clínica. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Instituto de Biomedicina para Semi-Árido Brasileiro. Unidade de Pesquisa Clínica. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Instituto de Biomedicina para Semi-Árido Brasileiro. Unidade de Pesquisa Clínica. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Instituto de Biomedicina para Semi-Árido Brasileiro. Unidade de Pesquisa Clínica. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Group A rotaviruses (RVA) and noroviruses (NoV) are the leading cause of acute gastroenteritis (AGE) worldwide. Childhood diarrhea deaths and hospital admissions have declined since the introduction of the monovalent (G1P- [8]) vaccine (Rotarix1 [RV1]) in the National Immunization Program in Brazil in 2006. This study aims to investigate the epidemiological profile of NoV and RVA infections from children with AGE in the Northeastern region of Brazil in the post vaccine season. Two-hundred fecal samples collected from children up to 10 years old in Fortaleza, Cear a between2008–2009 were screened for the presence of RVA and NoV. Positive samples were genotyped and sequenced. The RVA screening revealed 12% prevalence and all RVA strains belonged to G2P[4] genotype. Phylogenetic analysis based on the 11 RVA genome segments sequenced fromeight samples revealed a DS-1-like genotype constellation: I2-R2-C2-M2-A2-N2-T2-E2-H2. For NoV screening, the prevalence observed was 17% and the following genotypes were detected: GII.4 (59%), GII.12 (17%), GII.6 (9%), GII.3 (6%), and GII.? (9%). At least four different NoVs genotypes and two RVA G2P[4] variants were identified circulating in the Northeastern region of Brazil. RVA phylogenetic analysis suggests that the RVA G2P[4] strains might have originated from intragenogroup reassortment events. Whether the genetic modificationsobserved in these contemporary G2P[4] RVA strains may impact the long-term effectiveness of the current vaccination programs remains to be explored. These data reinforce the importance of surveillance for monitoring the emergence of new strains of RVA and NoV and their impact on cases of acute gastroenteritis.G2P[4] group A rotavirusAcute gastroenteritisGII.4 norovirusPhylogenetic analysisVaccineBrazilGastroenteriteNorovirusVacinainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/12000/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALanacaroline_sá_etal_IOC_2015.pdfanacaroline_sá_etal_IOC_2015.pdfapplication/pdf860767https://www.arca.fiocruz.br/bitstream/icict/12000/2/anacaroline_s%c3%a1_etal_IOC_2015.pdf4b2a3cdda2b6da34dbb949e72cab1ae3MD52TEXTanacaroline_sá_etal_IOC_2015.pdf.txtanacaroline_sá_etal_IOC_2015.pdf.txtExtracted texttext/plain42853https://www.arca.fiocruz.br/bitstream/icict/12000/3/anacaroline_s%c3%a1_etal_IOC_2015.pdf.txtb448750136d3f8607033f215fe61370cMD53icict/120002023-09-05 10:30:54.15oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:30:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era
title Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era
spellingShingle Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era
Sá, Ana Caroline C.
G2P[4] group A rotavirus
Acute gastroenteritis
GII.4 norovirus
Phylogenetic analysis
Vaccine
Brazil
Gastroenterite
Norovirus
Vacina
title_short Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era
title_full Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era
title_fullStr Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era
title_full_unstemmed Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era
title_sort Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era
author Sá, Ana Caroline C.
author_facet Sá, Ana Caroline C.
Gómez, Mariela Martínez
Lima, Ila Fernanda N.
Quetz, Josiane S.
Havt, Alexandre
Oriá, Reinaldo B.
Lima, Aldo A.
Leite, José Paulo G.
author_role author
author2 Gómez, Mariela Martínez
Lima, Ila Fernanda N.
Quetz, Josiane S.
Havt, Alexandre
Oriá, Reinaldo B.
Lima, Aldo A.
Leite, José Paulo G.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sá, Ana Caroline C.
Gómez, Mariela Martínez
Lima, Ila Fernanda N.
Quetz, Josiane S.
Havt, Alexandre
Oriá, Reinaldo B.
Lima, Aldo A.
Leite, José Paulo G.
dc.subject.en.pt_BR.fl_str_mv G2P[4] group A rotavirus
Acute gastroenteritis
GII.4 norovirus
Phylogenetic analysis
Vaccine
Brazil
topic G2P[4] group A rotavirus
Acute gastroenteritis
GII.4 norovirus
Phylogenetic analysis
Vaccine
Brazil
Gastroenterite
Norovirus
Vacina
dc.subject.decs.pt_BR.fl_str_mv Gastroenterite
Norovirus
Vacina
description 2015-12-31
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-10-20T14:42:30Z
dc.date.issued.fl_str_mv 2015
dc.date.available.fl_str_mv 2016-01-01T06:30:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SÁ, Ana Caroline C. et al. Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era. Journal of Medical Virology, v.87, p.1480–1490, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12000
dc.identifier.issn.none.fl_str_mv 1096-9071
dc.identifier.doi.none.fl_str_mv 10.1002/jmv
identifier_str_mv SÁ, Ana Caroline C. et al. Group A Rotavirus and Norovirus Genotypes Circulating in the Northeastern Brazil in the Post-Monovalent Vaccination Era. Journal of Medical Virology, v.87, p.1480–1490, 2015.
1096-9071
10.1002/jmv
url https://www.arca.fiocruz.br/handle/icict/12000
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Periodicals Inc.
publisher.none.fl_str_mv Wiley Periodicals Inc.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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