Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45774 |
Resumo: | Instituto Federal do Sudeste de Minas Gerais. Campus Avançado Cataguases. Cataguases, MG, Brasil. |
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Bonin, Carla Rezende BarbosaFernandes, Guilherme CôrtesMartins, Reinaldo de MenezesCamacho, Luiz Antonio BastosTeixeira-Carvalho, AndréaMota, Licia Maria Henrique daLima, Sheila Maria Barbosa deCampi-Azevedo, Ana CarolinaMartins-Filho, Olindo AssisSantos, Rodrigo Weber dosLobosco, Marcelo2021-01-21T19:16:21Z2021-01-21T19:16:21Z2020BONIN, Carla Rezende Barbosa et al. Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals. BMC Bioinformatics, v. 21, Suppl 17, p. 1-25, 2020.1471-2105https://www.arca.fiocruz.br/handle/icict/4577410.1186/s12859-020-03845-3engModelagem Computacional Específica para o PacienteSistema ImunitárioVacinasFebre AmarelaComputational ModelingImmune SystemMathematical ModelingOrdinary Differential EquationsVaccineYellow FeverImmune SystemYellow FeverPatient-Specific ModelingVaccinesValidation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Federal do Sudeste de Minas Gerais. Campus Avançado Cataguases. Cataguases, MG, Brasil.Centro Universitário Presidente Antônio Carlos. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Universidade de Brasilia. Brasilia, DF, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Juiz de Fora. Programa de Pós-Graduação em Modelagem Computacional. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Programa de Pós-Graduação em Modelagem Computacional. Juiz de Fora, MG, Brasil.Background: An effective yellow fever (YF) vaccine has been available since 1937. Nevertheless, questions regarding its use remain poorly understood, such as the ideal dose to confer immunity against the disease, the need for a booster dose, the optimal immunisation schedule for immunocompetent, immunosuppressed, and pediatric populations, among other issues. This work aims to demonstrate that computational tools can be used to simulate different scenarios regarding YF vaccination and the immune response of individuals to this vaccine, thus assisting the response of some of these open questions. Results: This work presents the computational results obtained by a mathematical model of the human immune response to vaccination against YF. Five scenarios were simulated: primovaccination in adults and children, booster dose in adult individuals, vaccination of individuals with autoimmune diseases under immunomodulatory therapy, and the immune response to different vaccine doses. Where data were available, the model was able to quantitatively replicate the levels of antibodies obtained experimentally. In addition, for those scenarios where data were not available, it was possible to qualitatively reproduce the immune response behaviours described in the literature. Conclusions: Our simulations show that the minimum dose to confer immunity against YF is half of the reference dose. The results also suggest that immunological immaturity in children limits the induction and persistence of long-lived plasma cells are related to the antibody decay observed experimentally. Finally, the decay observed in the antibody level after ten years suggests that a booster dose is necessary to keep immunity against YF.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45774/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALValidationYellowFeverVaccine.pdfValidationYellowFeverVaccine.pdfapplication/pdf1730767https://www.arca.fiocruz.br/bitstream/icict/45774/2/ValidationYellowFeverVaccine.pdfa86d5f9f10c894db1dd9c479eabd94a0MD52TEXTValidationYellowFeverVaccine.pdf.txtValidationYellowFeverVaccine.pdf.txtExtracted texttext/plain70598https://www.arca.fiocruz.br/bitstream/icict/45774/3/ValidationYellowFeverVaccine.pdf.txt8f370b110fae5fc2ec2a1e69af1be014MD53icict/457742021-02-10 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dc.title.pt_BR.fl_str_mv |
Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals |
title |
Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals |
spellingShingle |
Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals Bonin, Carla Rezende Barbosa Modelagem Computacional Específica para o Paciente Sistema Imunitário Vacinas Febre Amarela Computational Modeling Immune System Mathematical Modeling Ordinary Differential Equations Vaccine Yellow Fever Immune System Yellow Fever Patient-Specific Modeling Vaccines |
title_short |
Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals |
title_full |
Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals |
title_fullStr |
Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals |
title_full_unstemmed |
Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals |
title_sort |
Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals |
author |
Bonin, Carla Rezende Barbosa |
author_facet |
Bonin, Carla Rezende Barbosa Fernandes, Guilherme Côrtes Martins, Reinaldo de Menezes Camacho, Luiz Antonio Bastos Teixeira-Carvalho, Andréa Mota, Licia Maria Henrique da Lima, Sheila Maria Barbosa de Campi-Azevedo, Ana Carolina Martins-Filho, Olindo Assis Santos, Rodrigo Weber dos Lobosco, Marcelo |
author_role |
author |
author2 |
Fernandes, Guilherme Côrtes Martins, Reinaldo de Menezes Camacho, Luiz Antonio Bastos Teixeira-Carvalho, Andréa Mota, Licia Maria Henrique da Lima, Sheila Maria Barbosa de Campi-Azevedo, Ana Carolina Martins-Filho, Olindo Assis Santos, Rodrigo Weber dos Lobosco, Marcelo |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bonin, Carla Rezende Barbosa Fernandes, Guilherme Côrtes Martins, Reinaldo de Menezes Camacho, Luiz Antonio Bastos Teixeira-Carvalho, Andréa Mota, Licia Maria Henrique da Lima, Sheila Maria Barbosa de Campi-Azevedo, Ana Carolina Martins-Filho, Olindo Assis Santos, Rodrigo Weber dos Lobosco, Marcelo |
dc.subject.other.pt_BR.fl_str_mv |
Modelagem Computacional Específica para o Paciente Sistema Imunitário Vacinas Febre Amarela |
topic |
Modelagem Computacional Específica para o Paciente Sistema Imunitário Vacinas Febre Amarela Computational Modeling Immune System Mathematical Modeling Ordinary Differential Equations Vaccine Yellow Fever Immune System Yellow Fever Patient-Specific Modeling Vaccines |
dc.subject.en.pt_BR.fl_str_mv |
Computational Modeling Immune System Mathematical Modeling Ordinary Differential Equations Vaccine Yellow Fever |
dc.subject.decs.pt_BR.fl_str_mv |
Immune System Yellow Fever Patient-Specific Modeling Vaccines |
description |
Instituto Federal do Sudeste de Minas Gerais. Campus Avançado Cataguases. Cataguases, MG, Brasil. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-01-21T19:16:21Z |
dc.date.available.fl_str_mv |
2021-01-21T19:16:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
BONIN, Carla Rezende Barbosa et al. Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals. BMC Bioinformatics, v. 21, Suppl 17, p. 1-25, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45774 |
dc.identifier.issn.pt_BR.fl_str_mv |
1471-2105 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s12859-020-03845-3 |
identifier_str_mv |
BONIN, Carla Rezende Barbosa et al. Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals. BMC Bioinformatics, v. 21, Suppl 17, p. 1-25, 2020. 1471-2105 10.1186/s12859-020-03845-3 |
url |
https://www.arca.fiocruz.br/handle/icict/45774 |
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eng |
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eng |
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