Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37417 |
Resumo: | 2020-11-27 |
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Soares, MárcioCaruso, PedroSilva, EliézerTeles, José M. M.Lobo, Suzana M. A.Friedman, GilbertoDal Pizzol, FelipeMello, Patricia V. C.Bozza, Fernando A.Silva, Ulisses V. A.Torelly, André P.Knibel, Marcos F.Rezende, EderlonNetto, José J.Piras, ClaudioCastro, AlineFerreira, Bruno S.Réa-Neto, ÁlvaroOlmedo, Patrícia B.Salluh, Jorge I. F.The Brazilian Research in Intensive Care Network (BRICNet)2019-11-27T15:23:00Z2019-11-27T15:23:00Z2010SOARES, Márcio et al. Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study. Critical Care Medicine, v. 38, n. 1, p. 9-15, 2010.0090-3493https://www.arca.fiocruz.br/handle/icict/3741710.1097/CCM.0b013e3181c0349e1530-0293engLippincott, Williams & WilkinsCharacteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-27Instituto Nacional de Câncer. Hospital de Câncer. ICU. Rio de Janeiro, RJ, Brazil.Hospital A. C. Camargo. ICU. São Paulo, SP, Brazil.Hospital Israelita Albert Einstein. ICU. São Paulo, SP, Brazil.Hospital Português. ICU. Salvador, BA, Brazil.Medical School. Department of Internal Medicine. Division of Critical Care Medicine. São José do Rio Preto, SP, Brazil. / Hospital de Base. São José do Rio Preto, SP, Brazil.Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brazil / Santa Casa de Misericórdia de Porto Alegre. ICU. Porto Alegre, RS, Brazil.Universidade do Extremo Sul Catarinense. Unidade Acadêmica de Ciências da Saúde. Laboratório de Fisiopatologia Experimental. Programa de Pós-Graduação Ciências da Saúde. Criciúma, SC, Brasil.Universidade Estadual do Piauí. ICU. Teresina, PI, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisas Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Pio XII. Hospital do Câncer de Barretos. Barretos, SP, Brasil.Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brazil / Santa Casa de Misericórdia de Porto Alegre. ICU. Porto Alegre, RS, Brazil.Hospital São Lucas. Rio de Janeiro, RJ, Brasil.Hospital do Servidor Público Estadual. São Paulo, SP, Brazil.Instituto Nacional de Câncer. Hospital do Câncer II. ICU. Rio de Janeiro, RJ, Brazil.Vitória Apart Hospital. ICU. Vitória, ES, BrazilHospital Samaritano. ICU. Rio de Janeiro, RJ, Brazil.Hospital Pasteur. Rio de Janeiro, RJ, Brasil.Universidade Federal do Paraná. Hospital de Clínicas. ICU. Curitiba, PR, Brazil.Instituto Nacional de Câncer. Hospital de Câncer. ICU. Rio de Janeiro, RJ, Brazil.Instituto Nacional de Câncer. Hospital de Câncer. ICU. Rio de Janeiro, RJ, Brazil.Objective: To evaluate the characteristics and outcomes of patients with cancer admitted to several intensive care units. Knowledge on patients with cancer requiring intensive care is mostly restricted to single-center studies. Design: Prospective, multicenter, cohort study. Setting: Intensive care units from 28 hospitals in Brazil. Patients: A total of 717 consecutive patients included over a 2-mo period. Interventions: None. Measurements and Main Results: There were 667 (93%) patients with solid tumors and 50 (7%) patients had hematologic malignancies. The main reasons for intensive care unit admission were postoperative care (57%), sepsis (15%), and respiratory failure (10%). Overall hospital mortality rate was 30% and was higher in patients admitted because of medical complications (58%) than in emergency (37%) and scheduled (11%) surgical patients (p < .001). Adjusting for covariates other than the type of admission, the number of hospital days before intensive care unit admission (odds ratio [OR], 1.18; 95% confidence interval [CI], 1.01–1.37), higher Sequential Organ Failure Assessment scores (OR, 1.25; 95% CI, 1.17–1.34), poor performance status (OR, 3.40; 95% CI, 2.19 –5.26), the need for mechanical ventilation (OR, 2.42; 95% CI, 1.51–3.87), and active underlying malignancy in recurrence or progression (OR, 2.42; 95% CI, 1.51–3.87) were associated with increased hospital mortality in multivariate analysis. Conclusions: This large multicenter study reports encouraging survival rates for patients with cancer requiring intensive care. In these patients, mortality was mostly dependent on the severity of organ failures, performance status, and need for mechanical ventilation rather than cancer-related characteristics, such as the type of malignancy or the presence of neutropenia.CancerIntensive care unitMortalityMulticenter studyOutcomeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37417/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Soares_Márcio_etal_INI_2010.pdfve_Soares_Márcio_etal_INI_2010.pdfapplication/pdf377100https://www.arca.fiocruz.br/bitstream/icict/37417/2/ve_Soares_M%c3%a1rcio_etal_INI_2010.pdf0da81c1279d3ec0f2d75d8e3d31a9374MD52TEXTve_Soares_Márcio_etal_INI_2010.pdf.txtve_Soares_Márcio_etal_INI_2010.pdf.txtExtracted texttext/plain38280https://www.arca.fiocruz.br/bitstream/icict/37417/3/ve_Soares_M%c3%a1rcio_etal_INI_2010.pdf.txt3024d47f40a83d91d0954f409bd02d66MD53icict/374172021-03-24 16:32:39.654oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:39Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study |
| title |
Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study |
| spellingShingle |
Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study Soares, Márcio Cancer Intensive care unit Mortality Multicenter study Outcome |
| title_short |
Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study |
| title_full |
Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study |
| title_fullStr |
Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study |
| title_full_unstemmed |
Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study |
| title_sort |
Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study |
| author |
Soares, Márcio |
| author_facet |
Soares, Márcio Caruso, Pedro Silva, Eliézer Teles, José M. M. Lobo, Suzana M. A. Friedman, Gilberto Dal Pizzol, Felipe Mello, Patricia V. C. Bozza, Fernando A. Silva, Ulisses V. A. Torelly, André P. Knibel, Marcos F. Rezende, Ederlon Netto, José J. Piras, Claudio Castro, Aline Ferreira, Bruno S. Réa-Neto, Álvaro Olmedo, Patrícia B. Salluh, Jorge I. F. The Brazilian Research in Intensive Care Network (BRICNet) |
| author_role |
author |
| author2 |
Caruso, Pedro Silva, Eliézer Teles, José M. M. Lobo, Suzana M. A. Friedman, Gilberto Dal Pizzol, Felipe Mello, Patricia V. C. Bozza, Fernando A. Silva, Ulisses V. A. Torelly, André P. Knibel, Marcos F. Rezende, Ederlon Netto, José J. Piras, Claudio Castro, Aline Ferreira, Bruno S. Réa-Neto, Álvaro Olmedo, Patrícia B. Salluh, Jorge I. F. The Brazilian Research in Intensive Care Network (BRICNet) |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Soares, Márcio Caruso, Pedro Silva, Eliézer Teles, José M. M. Lobo, Suzana M. A. Friedman, Gilberto Dal Pizzol, Felipe Mello, Patricia V. C. Bozza, Fernando A. Silva, Ulisses V. A. Torelly, André P. Knibel, Marcos F. Rezende, Ederlon Netto, José J. Piras, Claudio Castro, Aline Ferreira, Bruno S. Réa-Neto, Álvaro Olmedo, Patrícia B. Salluh, Jorge I. F. The Brazilian Research in Intensive Care Network (BRICNet) |
| dc.subject.en.pt_BR.fl_str_mv |
Cancer Intensive care unit Mortality Multicenter study Outcome |
| topic |
Cancer Intensive care unit Mortality Multicenter study Outcome |
| description |
2020-11-27 |
| publishDate |
2010 |
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2010 |
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2019-11-27T15:23:00Z |
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2019-11-27T15:23:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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SOARES, Márcio et al. Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study. Critical Care Medicine, v. 38, n. 1, p. 9-15, 2010. |
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https://www.arca.fiocruz.br/handle/icict/37417 |
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0090-3493 |
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10.1097/CCM.0b013e3181c0349e |
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1530-0293 |
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SOARES, Márcio et al. Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study. Critical Care Medicine, v. 38, n. 1, p. 9-15, 2010. 0090-3493 10.1097/CCM.0b013e3181c0349e 1530-0293 |
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Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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