Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10582 |
Resumo: | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil |
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Oliveira, Tatiane TeixeiraCampos, Keina MacieleLima, Ana Tereza CerqueiraCarneiro, Tamires Cana BrasilVelozo, Eudes da SilvaMelo, Ingrid Christie Alexandrino RibeiroFigueiredo, Eugênia AbrantesOliveira, Eduardo de JesusVasconcelos, Dariz Flávia Silva Amorim dePontes-de-Carvalho, Lain CarlosNeves, Neuza Maria AlcântaraFigueiredo, Camila Alexandrina Viana2015-05-29T13:18:09Z2015-05-29T13:18:09Z2015OLIVEIRA, T. T. et al. Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma. DARU Journal of Pharmaceutical Sciences, v.23, p. 18, 2015.1560-8115https://www.arca.fiocruz.br/handle/icict/1058210.1186/s40199-015-0098-5engTehran University of Medical SciencesPotential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthmainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal da Paraíba. Centro de Biotecnologia. João Pessoa, PB, BrasilUniversidade Federal da Paraíba. Centro de Biotecnologia. João Pessoa, PB, BrasilUniversidade Federal da Paraíba. Centro de Biotecnologia. João Pessoa, PB, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilBackground: Asthma is an inflammatory condition characterized by airway hyperresponsiveness and chronic inflammation. The resolution of inflammation is an essential process to treat this condition. In this study we investigated the effect of Allium cepa L. extract (AcE) and quercetin (Qt) on cytokine and on smooth muscle contraction in vitro and its therapeutic potential in a murine model of asthma. Methods: AcE was obtained by maceration of Allium cepa L. and it was standardized in terms of quercetin concentration using high performance liquid chromatography (HPLC). In vitro, using AcE 10, 100 or 1000 μg/ml or Qt 3.5, 7.5, 15 μg/ml, we measured the concentration of cytokines in spleen cell culture supernatants, and the ability to relax tracheal smooth muscle from A/J mice. In vivo, Blomia tropicalis (BT)-sensitized A/J mice were treated with AcE 100, 1000 mg/kg or 30 mg/kg Qt. We measured cell influx in bronchoalveolar lavage (BAL), eosinophil peroxidase (EPO) in lungs, serum levels of Bt-specific IgE, cytokines levels in BAL, and lung histology. Results: We observed a reduction in the production of inflammatory cytokines, a relaxation of tracheal rings, and a reduction in total number of cells in BAL and EPO in lungs by treatment with AcE or Qt. Conclusion: AcE and Qt have potential as antiasthmatic drugs, as they possess both immunomodulatory and bronchodilatory properties.Natural productAsthmaBlomia tropicalisAllium cepa LQuercetininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10582/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALOliveira T T Potential therapeutic effect.pdfOliveira T T Potential therapeutic effect.pdfapplication/pdf3514278https://www.arca.fiocruz.br/bitstream/icict/10582/2/Oliveira%20T%20T%20Potential%20therapeutic%20effect.pdfb2c9da5ed5b0bff02c68999a535364d4MD52TEXTOliveira T T Potential therapeutic effect.pdf.txtOliveira T T Potential therapeutic effect.pdf.txtExtracted texttext/plain48012https://www.arca.fiocruz.br/bitstream/icict/10582/3/Oliveira%20T%20T%20Potential%20therapeutic%20effect.pdf.txtb0c33b86b7c88abe80fa8b5a41fef3b8MD53icict/105822023-03-15 14:33:12.87oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma |
| title |
Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma |
| spellingShingle |
Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma Oliveira, Tatiane Teixeira Natural product Asthma Blomia tropicalis Allium cepa L Quercetin |
| title_short |
Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma |
| title_full |
Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma |
| title_fullStr |
Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma |
| title_full_unstemmed |
Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma |
| title_sort |
Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma |
| author |
Oliveira, Tatiane Teixeira |
| author_facet |
Oliveira, Tatiane Teixeira Campos, Keina Maciele Lima, Ana Tereza Cerqueira Carneiro, Tamires Cana Brasil Velozo, Eudes da Silva Melo, Ingrid Christie Alexandrino Ribeiro Figueiredo, Eugênia Abrantes Oliveira, Eduardo de Jesus Vasconcelos, Dariz Flávia Silva Amorim de Pontes-de-Carvalho, Lain Carlos Neves, Neuza Maria Alcântara Figueiredo, Camila Alexandrina Viana |
| author_role |
author |
| author2 |
Campos, Keina Maciele Lima, Ana Tereza Cerqueira Carneiro, Tamires Cana Brasil Velozo, Eudes da Silva Melo, Ingrid Christie Alexandrino Ribeiro Figueiredo, Eugênia Abrantes Oliveira, Eduardo de Jesus Vasconcelos, Dariz Flávia Silva Amorim de Pontes-de-Carvalho, Lain Carlos Neves, Neuza Maria Alcântara Figueiredo, Camila Alexandrina Viana |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Tatiane Teixeira Campos, Keina Maciele Lima, Ana Tereza Cerqueira Carneiro, Tamires Cana Brasil Velozo, Eudes da Silva Melo, Ingrid Christie Alexandrino Ribeiro Figueiredo, Eugênia Abrantes Oliveira, Eduardo de Jesus Vasconcelos, Dariz Flávia Silva Amorim de Pontes-de-Carvalho, Lain Carlos Neves, Neuza Maria Alcântara Figueiredo, Camila Alexandrina Viana |
| dc.subject.en.pt_BR.fl_str_mv |
Natural product Asthma Blomia tropicalis Allium cepa L Quercetin |
| topic |
Natural product Asthma Blomia tropicalis Allium cepa L Quercetin |
| description |
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil |
| publishDate |
2015 |
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2015-05-29T13:18:09Z |
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2015-05-29T13:18:09Z |
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2015 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
OLIVEIRA, T. T. et al. Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma. DARU Journal of Pharmaceutical Sciences, v.23, p. 18, 2015. |
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https://www.arca.fiocruz.br/handle/icict/10582 |
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1560-8115 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s40199-015-0098-5 |
| identifier_str_mv |
OLIVEIRA, T. T. et al. Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma. DARU Journal of Pharmaceutical Sciences, v.23, p. 18, 2015. 1560-8115 10.1186/s40199-015-0098-5 |
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Tehran University of Medical Sciences |
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Tehran University of Medical Sciences |
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