Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene
| Autor(a) principal: | |
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| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13537 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil |
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Marliére, Newmar PintoEstivalis, José Manuel LatorreLorenzo, Marcelo GustavoCarrasco, DavidSilva, Juliana AlvesRodrigues, Juliana de OliveiraFerreira, Luciana de LimaLara, Luisa de MeloLowenberger, CarlGuarneri, Alessandra Aparecida2016-04-05T17:09:36Z2016-04-05T17:09:36Z2015MARLIÉRE, Newmar Pinto et al. Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene. PLoS Negl Trop Dis. 2015 Aug 20;9(8):e00039731935-2735https://www.arca.fiocruz.br/handle/icict/1353710.1371/journal.pntd.0003973engPublic Library of ScienceTrypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Geneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilSwedish University of Agricultural Sciences. Chemical Ecology Group, Department of Plant Protection Biology. Alnarp, SwedenFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilSimon Fraser University. Department of Biological Sciences. Burnaby, British Columbia, CanadaFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/Simon Fraser University. Department of Biological Sciences. Burnaby, British Columbia, CanadaBackground: As a result of evolution, the biology of triatomines must have been significantly adapted to accommodate trypanosome infection in a complex network of vector-vertebrate-parasite interactions. Arthropod-borne parasites have probably developed mechanisms, largely still unknown, to exploit the vector-vertebrate host interactions to ensure their transmission to suitable hosts. Triatomines exhibit a strong negative phototaxis and nocturnal activity, believed to be important for insect survival against its predators. Methodology/Principal Findings: In this study we quantified phototaxis and locomotion in starved fifth instar nymphs of Rhodnius prolixus infected with Trypanosoma cruzi or Trypanosoma rangeli. T. cruzi infection did not alter insect phototaxis, but induced an overall 20% decrease in the number of bug locomotory events. Furthermore, the significant differences induced by this parasite were concentrated at the beginning of the scotophase. Conversely, T. rangeli modified both behaviors, as it significantly decreased bug negative phototaxis, while it induced a 23% increase in the number of locomotory events in infected bugs. In this case, the significant effects were observed during the photophase. We also investigated the expression of Rpfor, the triatomine ortholog of the foraging gene known to modulate locomotion in other insects, and found a 4.8 fold increase for T. rangeli infected insects. Conclusions/Significance: We demonstrated for the first time that trypanosome infection modulates the locomotory activity of the invertebrate host. T. rangeli infection seems to be more broadly effective, as besides affecting the intensity of locomotion this parasite also diminished negative phototaxis and the expression of a behavior-associated gene in the triatomine vector.TriatominesTrypanosoma cruziT. rangeliinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13537/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTrypanosomes Modify the Behavior of Their Insect Hosts.pdfTrypanosomes Modify the Behavior of Their Insect Hosts.pdfapplication/pdf4225145https://www.arca.fiocruz.br/bitstream/icict/13537/2/Trypanosomes%20Modify%20the%20Behavior%20of%20Their%20Insect%20Hosts.pdf42d52a35e77c0f4be6524789d9092c70MD52TEXTTrypanosomes Modify the Behavior of Their Insect Hosts.pdf.txtTrypanosomes Modify the Behavior of Their Insect 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Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene |
| title |
Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene |
| spellingShingle |
Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene Marliére, Newmar Pinto Triatomines Trypanosoma cruzi T. rangeli |
| title_short |
Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene |
| title_full |
Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene |
| title_fullStr |
Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene |
| title_full_unstemmed |
Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene |
| title_sort |
Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene |
| author |
Marliére, Newmar Pinto |
| author_facet |
Marliére, Newmar Pinto Estivalis, José Manuel Latorre Lorenzo, Marcelo Gustavo Carrasco, David Silva, Juliana Alves Rodrigues, Juliana de Oliveira Ferreira, Luciana de Lima Lara, Luisa de Melo Lowenberger, Carl Guarneri, Alessandra Aparecida |
| author_role |
author |
| author2 |
Estivalis, José Manuel Latorre Lorenzo, Marcelo Gustavo Carrasco, David Silva, Juliana Alves Rodrigues, Juliana de Oliveira Ferreira, Luciana de Lima Lara, Luisa de Melo Lowenberger, Carl Guarneri, Alessandra Aparecida |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Marliére, Newmar Pinto Estivalis, José Manuel Latorre Lorenzo, Marcelo Gustavo Carrasco, David Silva, Juliana Alves Rodrigues, Juliana de Oliveira Ferreira, Luciana de Lima Lara, Luisa de Melo Lowenberger, Carl Guarneri, Alessandra Aparecida |
| dc.subject.en.pt_BR.fl_str_mv |
Triatomines Trypanosoma cruzi T. rangeli |
| topic |
Triatomines Trypanosoma cruzi T. rangeli |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil |
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2015 |
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2015 |
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2016-04-05T17:09:36Z |
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MARLIÉRE, Newmar Pinto et al. Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene. PLoS Negl Trop Dis. 2015 Aug 20;9(8):e0003973 |
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https://www.arca.fiocruz.br/handle/icict/13537 |
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1935-2735 |
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10.1371/journal.pntd.0003973 |
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MARLIÉRE, Newmar Pinto et al. Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene. PLoS Negl Trop Dis. 2015 Aug 20;9(8):e0003973 1935-2735 10.1371/journal.pntd.0003973 |
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