HIV-related lymphomas in adults served in the public health network: An observational study

Detalhes bibliográficos
Autor(a) principal: Nascimento, Janaíra da Silva
Data de Publicação: 2019
Outros Autores: Araújo, Paulo Sérgio Ramos de, Souza Júnior, Valter Romão de, Melo, Fábio Lopes de, Carvalho, Daniel Sá Araújo Lins, Magalhães, Vera
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35725
Resumo: The authors would like to thank Foundation for Science and Technology of Pernambuco (FACEPE-PPSUS 2017-10/2017)
id CRUZ_e8b3764243a03c3db729f06fb5cbe408
oai_identifier_str oai:www.arca.fiocruz.br:icict/35725
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Nascimento, Janaíra da SilvaAraújo, Paulo Sérgio Ramos deSouza Júnior, Valter Romão deMelo, Fábio Lopes deCarvalho, Daniel Sá Araújo LinsMagalhães, Vera2019-09-20T14:24:46Z2019-09-20T14:24:46Z2019NASCIMENTO, Janaíra da Silva et al. HIV-related lymphomas in adults served in the public health network. Medicine, v. 98, n. 26, p. 1-6, June 2019.1536-5964https://www.arca.fiocruz.br/handle/icict/3572510.1097/MD.000000000001612910.1097/MD.0000000000016129The authors would like to thank Foundation for Science and Technology of Pernambuco (FACEPE-PPSUS 2017-10/2017)Service of Onco-Hematology of Pernambuco Cancer. Recife, PE, Brasil / Foundation of Hematology and Hematology of Pernambuco. Recife, PE, Brasil / Universidade Federal de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade Federal de Pernambuco. Recife, PE, Brasil.Individuals infected with human immunodeficiency virus (HIV) have higher morbidity and mortality due to cancer, which is the third most common cause of death in this group, despite the high effectiveness of antiretroviral therapy (ART). We describe the clinical and laboratory characteristics, initial staging and outcome of HIV-related lymphoma. We included 18 patients in the study, of whom 61.1% were male, mean age 41 years. Nine of the 18 patients (50%) had a diagnosis of HIV infection concurrent with the diagnosis of lymphoma. The most common histological types were diffuse non-Hodgkin B-cell lymphoma, 8 patients (44.4%); and Burkitt lymphoma, 5 (27.8%) cases. The Cotswold revision of the Ann Arbor staging classification in 14 patients (77.7%) was between III and IV. B Symptoms were present in 11 patients (61.1%), bulky mass was observed in 11 cases (61.1%) and had extra-nodal involvement in 8 patients (44.4%). Of the 18 cases analyzed, 8 followed on to second-line treatment, wherein the CODOX-M/IVAC scheme (cyclophosphamide, adriamycin, vincristine, methotrexate/ifosfamide, etoposide, and cytosine arabinoside) was used in 3 of the cases. The second most common scheme was etoposide, doxorubicin, vincristine and cyclophosphamide (EPOCH), used in 2 cases (25%), while in single cases (12.5% each) cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP), ifosfamide, etoposide, and carboplatin (ICE) and dexamethasone, cisplatin, and cytarabine (DHAP) were used. In this series, we observed very high mortality, equivalent to 44.4%, and a complete response in only 11.1%, much lower than that observed by other authors. We found that patients diagnosed with lymphoma associated with HIV had an advanced early clinical staging, and evolved with low response rates to chemotherapy. Abbreviations: ART = antiretroviral therapy, CR = complete response, ECOG = Eastern Cooperative Oncology Group, EPOCH = etoposide, doxorubicin, vincristine, and cyclophosphamide, HIV = human immunodeficiency virus, LDH = lactate dehydrogenase. Keywords: human immunodeficiency virus, Lymphoma, Neoplasia.engHIV-related lymphomas in adults served in the public health network: An observational studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHuman immunodeficiency virusLymphomaNeoplasiaAdultoAntineoplásicos / uso terapêuticoLinfoma de Burkitt / epidemiologiaLinfoma de Burkitt / patologiaLinfoma de Burkitt / terapiaFêmeaHumanosLinfoma relacionado à AIDS / epidemiologiaLinfoma Relacionado à AIDS / patologiaLinfoma relacionado à AIDS / terapiaLinfoma não Hodgkin / epidemiologiaLinfoma Não Hodgkin / patologiaLinfoma Não Hodgkin / terapiaMasculinoEstadiamento da neoplasiaEstudos Retrospectivosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83094https://www.arca.fiocruz.br/bitstream/icict/35725/1/license.txtee3692f7b0b97d5638099ab94397d05fMD51ORIGINALHIV-related lymphomas in adults served in the.pdfHIV-related lymphomas in adults served in the.pdfapplication/pdf200206https://www.arca.fiocruz.br/bitstream/icict/35725/2/HIV-related%20lymphomas%20in%20adults%20served%20in%20the.pdf1453efcb070930b077cc65ae29f8151dMD52TEXTHIV-related lymphomas in adults served in the.pdf.txtHIV-related lymphomas in adults served in the.pdf.txtExtracted texttext/plain29357https://www.arca.fiocruz.br/bitstream/icict/35725/3/HIV-related%20lymphomas%20in%20adults%20served%20in%20the.pdf.txt9d3ea48ba294164f2e86440b08804aa6MD53icict/357252019-09-23 20:26:29.226oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-09-23T23:26:29Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv HIV-related lymphomas in adults served in the public health network: An observational study
title HIV-related lymphomas in adults served in the public health network: An observational study
spellingShingle HIV-related lymphomas in adults served in the public health network: An observational study
Nascimento, Janaíra da Silva
Human immunodeficiency virus
Lymphoma
Neoplasia
Adulto
Antineoplásicos / uso terapêutico
Linfoma de Burkitt / epidemiologia
Linfoma de Burkitt / patologia
Linfoma de Burkitt / terapia
Fêmea
Humanos
Linfoma relacionado à AIDS / epidemiologia
Linfoma Relacionado à AIDS / patologia
Linfoma relacionado à AIDS / terapia
Linfoma não Hodgkin / epidemiologia
Linfoma Não Hodgkin / patologia
Linfoma Não Hodgkin / terapia
Masculino
Estadiamento da neoplasia
Estudos Retrospectivos
title_short HIV-related lymphomas in adults served in the public health network: An observational study
title_full HIV-related lymphomas in adults served in the public health network: An observational study
title_fullStr HIV-related lymphomas in adults served in the public health network: An observational study
title_full_unstemmed HIV-related lymphomas in adults served in the public health network: An observational study
title_sort HIV-related lymphomas in adults served in the public health network: An observational study
author Nascimento, Janaíra da Silva
author_facet Nascimento, Janaíra da Silva
Araújo, Paulo Sérgio Ramos de
Souza Júnior, Valter Romão de
Melo, Fábio Lopes de
Carvalho, Daniel Sá Araújo Lins
Magalhães, Vera
author_role author
author2 Araújo, Paulo Sérgio Ramos de
Souza Júnior, Valter Romão de
Melo, Fábio Lopes de
Carvalho, Daniel Sá Araújo Lins
Magalhães, Vera
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento, Janaíra da Silva
Araújo, Paulo Sérgio Ramos de
Souza Júnior, Valter Romão de
Melo, Fábio Lopes de
Carvalho, Daniel Sá Araújo Lins
Magalhães, Vera
dc.subject.en.pt_BR.fl_str_mv Human immunodeficiency virus
Lymphoma
Neoplasia
topic Human immunodeficiency virus
Lymphoma
Neoplasia
Adulto
Antineoplásicos / uso terapêutico
Linfoma de Burkitt / epidemiologia
Linfoma de Burkitt / patologia
Linfoma de Burkitt / terapia
Fêmea
Humanos
Linfoma relacionado à AIDS / epidemiologia
Linfoma Relacionado à AIDS / patologia
Linfoma relacionado à AIDS / terapia
Linfoma não Hodgkin / epidemiologia
Linfoma Não Hodgkin / patologia
Linfoma Não Hodgkin / terapia
Masculino
Estadiamento da neoplasia
Estudos Retrospectivos
dc.subject.decs.pt_BR.fl_str_mv Adulto
Antineoplásicos / uso terapêutico
Linfoma de Burkitt / epidemiologia
Linfoma de Burkitt / patologia
Linfoma de Burkitt / terapia
Fêmea
Humanos
Linfoma relacionado à AIDS / epidemiologia
Linfoma Relacionado à AIDS / patologia
Linfoma relacionado à AIDS / terapia
Linfoma não Hodgkin / epidemiologia
Linfoma Não Hodgkin / patologia
Linfoma Não Hodgkin / terapia
Masculino
Estadiamento da neoplasia
Estudos Retrospectivos
description The authors would like to thank Foundation for Science and Technology of Pernambuco (FACEPE-PPSUS 2017-10/2017)
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-20T14:24:46Z
dc.date.available.fl_str_mv 2019-09-20T14:24:46Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NASCIMENTO, Janaíra da Silva et al. HIV-related lymphomas in adults served in the public health network. Medicine, v. 98, n. 26, p. 1-6, June 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35725
dc.identifier.issn.pt_BR.fl_str_mv 1536-5964
dc.identifier.doi.pt_BR.fl_str_mv 10.1097/MD.0000000000016129
dc.identifier.eissn.none.fl_str_mv 10.1097/MD.0000000000016129
identifier_str_mv NASCIMENTO, Janaíra da Silva et al. HIV-related lymphomas in adults served in the public health network. Medicine, v. 98, n. 26, p. 1-6, June 2019.
1536-5964
10.1097/MD.0000000000016129
url https://www.arca.fiocruz.br/handle/icict/35725
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/35725/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/35725/2/HIV-related%20lymphomas%20in%20adults%20served%20in%20the.pdf
https://www.arca.fiocruz.br/bitstream/icict/35725/3/HIV-related%20lymphomas%20in%20adults%20served%20in%20the.pdf.txt
bitstream.checksum.fl_str_mv ee3692f7b0b97d5638099ab94397d05f
1453efcb070930b077cc65ae29f8151d
9d3ea48ba294164f2e86440b08804aa6
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324779855380480

Registros relacionados