Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal

Engelthaler, David M.; Hicks, Nathan D.; Gillece, John D.; Roe, Chandler C.; Schupp, James M.; Driebe, Elizabeth M.; Gilgado, Felix; Carriconde, Fabian; Trilles, Luciana; Firacative, Carolina; Ngamskulrungroj, Popchai; Castañeda, Elizabeth; Lazera, Marcia dos Santos; Melhem, Márcia de Souza Carvalho; Bercoff, Asa Perez; Huttley, Gavin; Sorrell, Tania C.; Voelz, Kerstin; May, Robin C.; Fisher, Matthew C.; Thompson, George R.; Lockhart, Shawn R.; Keim, Paul; Meyer, Wieland

Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal

Detalhes bibliográficos
Autor(a) principal:	Engelthaler, David M.
Data de Publicação:	2014
Outros Autores:	Hicks, Nathan D., Gillece, John D., Roe, Chandler C., Schupp, James M., Driebe, Elizabeth M., Gilgado, Felix, Carriconde, Fabian, Trilles, Luciana, Firacative, Carolina, Ngamskulrungroj, Popchai, Castañeda, Elizabeth, Lazera, Marcia dos Santos, Melhem, Márcia de Souza Carvalho, Bercoff, Asa Perez, Huttley, Gavin, Sorrell, Tania C., Voelz, Kerstin, May, Robin C., Fisher, Matthew C., Thompson, George R., Lockhart, Shawn R., Keim, Paul, Meyer, Wieland
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/11417
Resumo:	Translational Genomics Research Institute. Flagstaff, AZ, USA.

Metadados do item

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spelling	Engelthaler, David M.Hicks, Nathan D.Gillece, John D.Roe, Chandler C.Schupp, James M.Driebe, Elizabeth M.Gilgado, FelixCarriconde, FabianTrilles, LucianaFiracative, CarolinaNgamskulrungroj, PopchaiCastañeda, ElizabethLazera, Marcia dos SantosMelhem, Márcia de Souza CarvalhoBercoff, Asa PerezHuttley, GavinSorrell, Tania C.Voelz, KerstinMay, Robin C.Fisher, Matthew C.Thompson, George R.Lockhart, Shawn R.Keim, PaulMeyer, Wieland2015-07-29T20:58:34Z2015-07-29T20:58:34Z2014ENGELTHALER, David M. et al. Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal. mBio, v. 27, n. 4, p. 980-1024, 2014.2150-7511https://www.arca.fiocruz.br/handle/icict/1141710.1128/mBio.01464-142150-7511engAmerican Society for MicrobiologyCryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTranslational Genomics Research Institute. Flagstaff, AZ, USA.Translational Genomics Research Institute. Flagstaff, AZ, USA.Translational Genomics Research Institute. Flagstaff, AZ, USA.Translational Genomics Research Institute. Flagstaff, AZ, USA.Translational Genomics Research Institute. Flagstaff, AZ, USA.Translational Genomics Research Institute. Flagstaff, AZ, USA.The University of Sydney. Westmead Hospital. Sydney Medical School. Center for Infectious Diseases and Microbiology. Molecular Mycology Research Laboratory. Marie Bashir Institute for Infectious Diseases and Biosecurity. Sydney, Australia.The University of Sydney. Westmead Hospital. Sydney Medical School. Center for Infectious Diseases and Microbiology. Molecular Mycology Research Laboratory. Marie Bashir Institute for Infectious Diseases and Biosecurity. Sydney, Australia / Institut Agronomique Néo-Calédonien. Noumea, New Caledonia.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil / The University of Sydney. Westmead Hospital. Sydney Medical School. Center for Infectious Diseases and Microbiology. Molecular Mycology Research Laboratory. Marie Bashir Institute for Infectious Diseases and Biosecurity. Sydney, Australia.The University of Sydney. Westmead Hospital. Sydney Medical School. Center for Infectious Diseases and Microbiology. Molecular Mycology Research Laboratory. Marie Bashir Institute for Infectious Diseases and Biosecurity. Sydney, Australia / Instituto Nacional de Salud. Microbiology Group. Bogotá, Colombia.The University of Sydney. Westmead Hospital. Sydney Medical School. Center for Infectious Diseases and Microbiology. Molecular Mycology Research Laboratory. Marie Bashir Institute for Infectious Diseases and Biosecurity. Sydney, Australia / Mahidol University. Siriraj Hospital. Faculty of Medicine. Department of Microbiology. Bangkok, Thailand.Instituto Nacional de Salud. Microbiology Group. Bogotá, Colombia.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Instituto Adolfo Lutz. Laboratório de Saúde Pública. São Paulo, SP, Brasil.The University of Sydney. Westmead Hospital. Sydney Medical School. Center for Infectious Diseases and Microbiology. Molecular Mycology Research Laboratory. Marie Bashir Institute for Infectious Diseases and Biosecurity. Sydney, Australia / Australian National University. John Curtin School of Medical Research. Canberra, Australia.Australian National University. John Curtin School of Medical Research. Canberra, Australia.The University of Sydney. Westmead Hospital. Sydney Medical School. Center for Infectious Diseases and Microbiology. Molecular Mycology Research Laboratory. Marie Bashir Institute for Infectious Diseases and Biosecurity. Sydney, Australia.University of Birmingham. School of Biosciences. Institute of Microbiology and Infection. Birmingham, United Kingdom / Queen Elizabeth Hospital. National Institute for Health Research Surgical Reconstruction. Microbiology Research Centre. Birmingham, UK.University of Birmingham. School of Biosciences. Institute of Microbiology and Infection. Birmingham, United Kingdom / Queen Elizabeth Hospital. National Institute for Health Research Surgical Reconstruction. Microbiology Research Centre. Birmingham, UK.Imperial College London. Department of Infectious Disease Epidemiology. London, UK.University of California. Davis, CA, USA.Centers for Disease Control and Prevention. Atlanta, GA, USA.Translational Genomics Research Institute. Flagstaff, AZ, United States of America / Northern Arizona University. Microbial Genetics and Genomics Center. Flagstaff, AZ, USA.The University of Sydney. Westmead Hospital. Sydney Medical School. Center for Infectious Diseases and Microbiology. Molecular Mycology Research Laboratory. Marie Bashir Institute for Infectious Diseases and Biosecurity. Sydney, Australia.The emergence of distinct populations of Cryptococcus gattii in the temperate North American Pacific Northwest (PNW) was surprising, as this species was previously thought to be confined to tropical and semitropical regions. Beyond a new habitat niche, the dominant emergent population displayed increased virulence and caused primary pulmonary disease, as opposed to the predominantly neurologic disease seen previously elsewhere. Whole-genome sequencing was performed on 118 C. gattii isolates, including the PNW subtypes and the global diversity of molecular type VGII, to better ascertain the natural source and genomic adaptations leading to the emergence of infection in the PNW. Overall, the VGII population was highly diverse, demonstrating large numbers of mutational and recombinational events; however, the three dominant subtypes from the PNW were of low diversity and were completely clonal. Although strains of VGII were found on at least five continents, all genetic subpopulations were represented or were most closely related to strains from South America. The phylogenetic data are consistent with multiple dispersal events from South America to North America and elsewhere. Numerous gene content differences were identified between the emergent clones and other VGII lineages, including genes potentially related to habitat adaptation, virulence, and pathology. Evidence was also found for possible gene introgression from Cryptococcus neoformans var. grubii that is rarely seen in global C. gattii but that was present in all PNW populations. These findings provide greater understanding of C. gattii evolution in North America and support extensive evolution in, and dispersal from, South America. IMPORTANCE Cryptococcus gattii emerged in the temperate North American Pacific Northwest (PNW) in the late 1990s. Beyond a new environmental niche, these emergent populations displayed increased virulence and resulted in a different pattern of clinical disease. In particular, severe pulmonary infections predominated in contrast to presentation with neurologic disease as seen previously elsewhere. We employed population-level whole-genome sequencing and analysis to explore the genetic relationships and gene content of the PNW C. gattii populations. We provide evidence that the PNW strains originated from South America and identified numerous genes potentially related to habitat adaptation, virulence expression, and clinical presentation. Characterization of these genetic features may lead to improved diagnostics and therapies for such fungal infections. The data indicate that there were multiple recent introductions of C. gattii into the PNW. Public health vigilance is warranted for emergence in regions where C. gattii is not thought to be endemic.Cryptococcus gattiiCryptococcus neoformansNorth AmericaSouth AmericaCryptococcus gattiiCryptococcus neoformansAmérica do NorteAmérica do Sulinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11417/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALCryptococcus gattii in North American Pacific Northwest whole-population genome analysis provides insights into species evolution and dispersal..pdfCryptococcus gattii in North American Pacific Northwest whole-population genome analysis provides insights into species evolution and dispersal..pdfapplication/pdf4058441https://www.arca.fiocruz.br/bitstream/icict/11417/2/Cryptococcus%20gattii%20in%20North%20American%20Pacific%20Northwest%20whole-population%20genome%20analysis%20provides%20insights%20into%20species%20evolution%20and%20dispersal..pdf8c40f1ed17bc620560fa9b75b25daf56MD52TEXTCryptococcus gattii in North American Pacific Northwest whole-population genome analysis provides insights into species evolution and dispersal..pdf.txtCryptococcus gattii in North American Pacific Northwest whole-population genome analysis provides insights into species evolution and dispersal..pdf.txtExtracted texttext/plain91779https://www.arca.fiocruz.br/bitstream/icict/11417/3/Cryptococcus%20gattii%20in%20North%20American%20Pacific%20Northwest%20whole-population%20genome%20analysis%20provides%20insights%20into%20species%20evolution%20and%20dispersal..pdf.txt7536c6442e92c7df2dc47a6e56103239MD53icict/114172019-09-09 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dc.title.pt_BR.fl_str_mv	Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal
title	Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal
spellingShingle	Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal Engelthaler, David M. Cryptococcus gattii Cryptococcus neoformans North America South America Cryptococcus gattii Cryptococcus neoformans América do Norte América do Sul
title_short	Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal
title_full	Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal
title_fullStr	Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal
title_full_unstemmed	Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal
title_sort	Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal
author	Engelthaler, David M.
author_facet	Engelthaler, David M. Hicks, Nathan D. Gillece, John D. Roe, Chandler C. Schupp, James M. Driebe, Elizabeth M. Gilgado, Felix Carriconde, Fabian Trilles, Luciana Firacative, Carolina Ngamskulrungroj, Popchai Castañeda, Elizabeth Lazera, Marcia dos Santos Melhem, Márcia de Souza Carvalho Bercoff, Asa Perez Huttley, Gavin Sorrell, Tania C. Voelz, Kerstin May, Robin C. Fisher, Matthew C. Thompson, George R. Lockhart, Shawn R. Keim, Paul Meyer, Wieland
author_role	author
author2	Hicks, Nathan D. Gillece, John D. Roe, Chandler C. Schupp, James M. Driebe, Elizabeth M. Gilgado, Felix Carriconde, Fabian Trilles, Luciana Firacative, Carolina Ngamskulrungroj, Popchai Castañeda, Elizabeth Lazera, Marcia dos Santos Melhem, Márcia de Souza Carvalho Bercoff, Asa Perez Huttley, Gavin Sorrell, Tania C. Voelz, Kerstin May, Robin C. Fisher, Matthew C. Thompson, George R. Lockhart, Shawn R. Keim, Paul Meyer, Wieland
author2_role	author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Engelthaler, David M. Hicks, Nathan D. Gillece, John D. Roe, Chandler C. Schupp, James M. Driebe, Elizabeth M. Gilgado, Felix Carriconde, Fabian Trilles, Luciana Firacative, Carolina Ngamskulrungroj, Popchai Castañeda, Elizabeth Lazera, Marcia dos Santos Melhem, Márcia de Souza Carvalho Bercoff, Asa Perez Huttley, Gavin Sorrell, Tania C. Voelz, Kerstin May, Robin C. Fisher, Matthew C. Thompson, George R. Lockhart, Shawn R. Keim, Paul Meyer, Wieland
dc.subject.en.pt_BR.fl_str_mv	Cryptococcus gattii Cryptococcus neoformans North America South America
topic	Cryptococcus gattii Cryptococcus neoformans North America South America Cryptococcus gattii Cryptococcus neoformans América do Norte América do Sul
dc.subject.decs.pt_BR.fl_str_mv	Cryptococcus gattii Cryptococcus neoformans América do Norte América do Sul
description	Translational Genomics Research Institute. Flagstaff, AZ, USA.
publishDate	2014
dc.date.issued.fl_str_mv	2014
dc.date.accessioned.fl_str_mv	2015-07-29T20:58:34Z
dc.date.available.fl_str_mv	2015-07-29T20:58:34Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ENGELTHALER, David M. et al. Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal. mBio, v. 27, n. 4, p. 980-1024, 2014.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/11417
dc.identifier.issn.none.fl_str_mv	2150-7511
dc.identifier.doi.none.fl_str_mv	10.1128/mBio.01464-14
dc.identifier.eissn.none.fl_str_mv	2150-7511
identifier_str_mv	ENGELTHALER, David M. et al. Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal. mBio, v. 27, n. 4, p. 980-1024, 2014. 2150-7511 10.1128/mBio.01464-14
url	https://www.arca.fiocruz.br/handle/icict/11417
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	American Society for Microbiology
publisher.none.fl_str_mv	American Society for Microbiology
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/11417/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/11417/2/Cryptococcus%20gattii%20in%20North%20American%20Pacific%20Northwest%20whole-population%20genome%20analysis%20provides%20insights%20into%20species%20evolution%20and%20dispersal..pdf https://www.arca.fiocruz.br/bitstream/icict/11417/3/Cryptococcus%20gattii%20in%20North%20American%20Pacific%20Northwest%20whole-population%20genome%20analysis%20provides%20insights%20into%20species%20evolution%20and%20dispersal..pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal

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