Pathology of periportal fibrosis involution in human schistosomiasis.

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 1992
Outros Autores: Peixoto, Ediriomar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5707
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Zilton de AraújoPeixoto, Ediriomar2012-10-22T18:36:05Z2012-10-22T18:36:05Z1992ANDRADE, Z.A.; PEIXOTO, E. Pathology of periportal fibrosis involution in human schistosomiasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 34, n. 4, p. 263-72, jul.-aug. 1992.0036-4665https://www.arca.fiocruz.br/handle/icict/5707engPathology of periportal fibrosis involution in human schistosomiasis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital Central Roberto Santos. Salvador, BA, BrasilOptical and electron microscopical evidences of focal matrix degradation were frequently seen in liver sections of periportal fibrosis caused by schistosomiasis mansoni in man. The material came from 14 wedge hepatic biopsies taken from patients with chronic advanced hepatosplenic disease and undergoing operations for the relief of portal hypertension. Besides the presence of focal areas of rarefaction, fragmentation and dispersion of collagen fibers, the enlarged portal spaces also showed hyperplasia of elastic tissue and disarray of smooth muscle fibers following destruction of portal vein branches. Eggs were scanty in the tissue sections, and matrix degradation probably represented involuting changes related to the progressive diminution of parasite-related aggression, which occurs spontaneously with age or after cure by chemotherapy. The changes indicative of matrix degradation now described are probably the basic morphological counterpart of periportal fibrosis involution currently being documented by ultrasonography in hepatosplenic patients submitted to curative chemotherapy.Matrix degradationFibrosisSchistosomiasisCollagenChemotherapyFígado/patologiaEsquistossomose mansoni/patologiaAdolescenteAdultoBiópsiaColágeno/metabolismoFemininoFibroseHepatomegalia/etiologiaHepatomegalia/metabolismoHepatomegalia/patologiaHumanosImunoistoquímicaFígado/metabolismoMasculinoMicroscopia EletrônicaMeia-IdadeEsquistossomose mansoni/complicaçõesEsquistossomose mansoni/metabolismoEsplenomegalia/etiologiaEsplenomegalia/metabolismoEsplenomegalia/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade ZA Pathology of periportal....pdfAndrade ZA Pathology of periportal....pdfapplication/pdf1547893https://www.arca.fiocruz.br/bitstream/icict/5707/1/Andrade%20ZA%20Pathology%20of%20periportal....pdf51de3408dfea201351ed19adc7934159MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5707/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade ZA Pathology of periportal....pdf.txtAndrade ZA Pathology of periportal....pdf.txtExtracted texttext/plain10https://www.arca.fiocruz.br/bitstream/icict/5707/5/Andrade%20ZA%20Pathology%20of%20periportal....pdf.txt2c6eb67c8897d916ae47524b1a844d3fMD55THUMBNAILAndrade ZA Pathology of periportal....pdf.jpgAndrade ZA Pathology of periportal....pdf.jpgGenerated Thumbnailimage/jpeg1898https://www.arca.fiocruz.br/bitstream/icict/5707/4/Andrade%20ZA%20Pathology%20of%20periportal....pdf.jpg5002cc0d370c809a7c6300d6a263ff3fMD54icict/57072023-03-15 14:33:14.473oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Pathology of periportal fibrosis involution in human schistosomiasis.
title Pathology of periportal fibrosis involution in human schistosomiasis.
spellingShingle Pathology of periportal fibrosis involution in human schistosomiasis.
Andrade, Zilton de Araújo
Matrix degradation
Fibrosis
Schistosomiasis
Collagen
Chemotherapy
Fígado/patologia
Esquistossomose mansoni/patologia
Adolescente
Adulto
Biópsia
Colágeno/metabolismo
Feminino
Fibrose
Hepatomegalia/etiologia
Hepatomegalia/metabolismo
Hepatomegalia/patologia
Humanos
Imunoistoquímica
Fígado/metabolismo
Masculino
Microscopia Eletrônica
Meia-Idade
Esquistossomose mansoni/complicações
Esquistossomose mansoni/metabolismo
Esplenomegalia/etiologia
Esplenomegalia/metabolismo
Esplenomegalia/patologia
title_short Pathology of periportal fibrosis involution in human schistosomiasis.
title_full Pathology of periportal fibrosis involution in human schistosomiasis.
title_fullStr Pathology of periportal fibrosis involution in human schistosomiasis.
title_full_unstemmed Pathology of periportal fibrosis involution in human schistosomiasis.
title_sort Pathology of periportal fibrosis involution in human schistosomiasis.
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Peixoto, Ediriomar
author_role author
author2 Peixoto, Ediriomar
author2_role author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Peixoto, Ediriomar
dc.subject.en.pt_BR.fl_str_mv Matrix degradation
Fibrosis
Schistosomiasis
Collagen
Chemotherapy
topic Matrix degradation
Fibrosis
Schistosomiasis
Collagen
Chemotherapy
Fígado/patologia
Esquistossomose mansoni/patologia
Adolescente
Adulto
Biópsia
Colágeno/metabolismo
Feminino
Fibrose
Hepatomegalia/etiologia
Hepatomegalia/metabolismo
Hepatomegalia/patologia
Humanos
Imunoistoquímica
Fígado/metabolismo
Masculino
Microscopia Eletrônica
Meia-Idade
Esquistossomose mansoni/complicações
Esquistossomose mansoni/metabolismo
Esplenomegalia/etiologia
Esplenomegalia/metabolismo
Esplenomegalia/patologia
dc.subject.decs.pt_BR.fl_str_mv Fígado/patologia
Esquistossomose mansoni/patologia
Adolescente
Adulto
Biópsia
Colágeno/metabolismo
Feminino
Fibrose
Hepatomegalia/etiologia
Hepatomegalia/metabolismo
Hepatomegalia/patologia
Humanos
Imunoistoquímica
Fígado/metabolismo
Masculino
Microscopia Eletrônica
Meia-Idade
Esquistossomose mansoni/complicações
Esquistossomose mansoni/metabolismo
Esplenomegalia/etiologia
Esplenomegalia/metabolismo
Esplenomegalia/patologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2012-10-22T18:36:05Z
dc.date.available.fl_str_mv 2012-10-22T18:36:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Z.A.; PEIXOTO, E. Pathology of periportal fibrosis involution in human schistosomiasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 34, n. 4, p. 263-72, jul.-aug. 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5707
dc.identifier.issn.none.fl_str_mv 0036-4665
identifier_str_mv ANDRADE, Z.A.; PEIXOTO, E. Pathology of periportal fibrosis involution in human schistosomiasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 34, n. 4, p. 263-72, jul.-aug. 1992.
0036-4665
url https://www.arca.fiocruz.br/handle/icict/5707
dc.language.iso.fl_str_mv eng
language eng
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