Significance and fate of septal fibrosis of the liver

Detalhes bibliográficos
Autor(a) principal: Souza, Márcia Maria de
Data de Publicação: 2006
Outros Autores: Tolentino, Miguel, Assis, Bárbara Cristina Alves de, de Oliveira Gonzalez, Ana Cristina, Silva, Tânia Maria Correia, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15201
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
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spelling Souza, Márcia Maria deTolentino, MiguelAssis, Bárbara Cristina Alves dede Oliveira Gonzalez, Ana CristinaSilva, Tânia Maria CorreiaAndrade, Zilton de Araújo2016-08-08T13:27:25Z2016-08-08T13:27:25Z2006SOUZA, M. M. et al. Significance and fate of septal fibrosis of the liver. Hepatology Research, v. 35, p. 31–36, 2006.1386-6346https://www.arca.fiocruz.br/handle/icict/1520110.1016/j.hepres.2006.01.010engWileySignificance and fate of septal fibrosis of the liverinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilSeptal fibrosis commonly occurs during chronic diseases of the liver. It is experimentally reproduced in a proportion of rats treated with pig-serum, and in 100% of rats infected with Capillaria hepatica. These models have only been used in relatively short-term studies. To contribute to the natural history and significance of hepatic septal fibrosis it is important to disclose its fate after prolonged observation, and following partial or total withdrawal of its inciting cause. Adult Wistar rats were sacrificed 3, 6, 9 and 12 months following inoculation of 800 embryonated eggs of C. hepatica. Besides routine histology, liver sections were submitted to immunohistochemical, immunofluorescence and ultrastructural techniques for the identification of cells and extracellular matrix components present in the fibrous septa. Septal blood vessels were studied after portal vein perfusion with India-ink, while the hepatic functional profile and levels of anti-C. hepatica antibodies were determined in collected sera. Results revealed that all parasites were already dead 2 months from inoculation, and the accumulated eggs in the liver lost their capacity to embryonate around the 4th-6th month, when progressive reduction in the number of cells and in the amount of collagen occurred in the septa. Septal fibrosis persisted throughout the time of experimentation (12 months). This fibrosis was seen as a supporting stroma for septal vessels that conducted portal blood directly to the sinusoids. Thus, persistence of fibrosis was probably related to its morphological and functional association with blood vessels.Capillaria hepaticaSeptal hepatic fibrosisFibrosis reversibilityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15201/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSouza MM Significance and fate of septal fibrosis of the liver.pdfSouza MM Significance and fate of septal fibrosis of the liver.pdfapplication/pdf550334https://www.arca.fiocruz.br/bitstream/icict/15201/2/Souza%20MM%20Significance%20and%20fate%20of%20septal%20fibrosis%20of%20the%20liver.pdf163dafc6728f39a20bcc0ddd458d0637MD52TEXTSouza MM Significance and fate of septal fibrosis of the liver.pdf.txtSouza MM Significance and fate of septal fibrosis of the liver.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Significance and fate of septal fibrosis of the liver
title Significance and fate of septal fibrosis of the liver
spellingShingle Significance and fate of septal fibrosis of the liver
Souza, Márcia Maria de
Capillaria hepatica
Septal hepatic fibrosis
Fibrosis reversibility
title_short Significance and fate of septal fibrosis of the liver
title_full Significance and fate of septal fibrosis of the liver
title_fullStr Significance and fate of septal fibrosis of the liver
title_full_unstemmed Significance and fate of septal fibrosis of the liver
title_sort Significance and fate of septal fibrosis of the liver
author Souza, Márcia Maria de
author_facet Souza, Márcia Maria de
Tolentino, Miguel
Assis, Bárbara Cristina Alves de
de Oliveira Gonzalez, Ana Cristina
Silva, Tânia Maria Correia
Andrade, Zilton de Araújo
author_role author
author2 Tolentino, Miguel
Assis, Bárbara Cristina Alves de
de Oliveira Gonzalez, Ana Cristina
Silva, Tânia Maria Correia
Andrade, Zilton de Araújo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Márcia Maria de
Tolentino, Miguel
Assis, Bárbara Cristina Alves de
de Oliveira Gonzalez, Ana Cristina
Silva, Tânia Maria Correia
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Capillaria hepatica
Septal hepatic fibrosis
Fibrosis reversibility
topic Capillaria hepatica
Septal hepatic fibrosis
Fibrosis reversibility
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2016-08-08T13:27:25Z
dc.date.available.fl_str_mv 2016-08-08T13:27:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, M. M. et al. Significance and fate of septal fibrosis of the liver. Hepatology Research, v. 35, p. 31–36, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15201
dc.identifier.issn.pt_BR.fl_str_mv 1386-6346
dc.identifier.doi.none.fl_str_mv 10.1016/j.hepres.2006.01.010
identifier_str_mv SOUZA, M. M. et al. Significance and fate of septal fibrosis of the liver. Hepatology Research, v. 35, p. 31–36, 2006.
1386-6346
10.1016/j.hepres.2006.01.010
url https://www.arca.fiocruz.br/handle/icict/15201
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15201/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/15201/3/Souza%20MM%20Significance%20and%20fate%20of%20septal%20fibrosis%20of%20the%20liver.pdf.txt
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