Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Nascimento, Maurício T.
Data de Publicação: 2021
Outros Autores: Franca, Mônica, Carvalho, Augusto M., Amorim, Camila F., Peixoto, Fábio, Beiting, Daniel, Scott, Phillip, Carvalho, Edgar Marcelino, Carvalho, Lucas Pedreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47866
Resumo: National Institutes of Health [AI 094577].
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spelling Nascimento, Maurício T.Franca, MônicaCarvalho, Augusto M.Amorim, Camila F.Peixoto, FábioBeiting, DanielScott, PhillipCarvalho, Edgar MarcelinoCarvalho, Lucas Pedreira2021-06-25T14:08:40Z2021-06-25T14:08:40Z2021NASCIMENTO, Maurício T. et al. Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis. Emerging Microbes and Infections, v. 10, n. 1, 16 June 2021.2222-1751https://www.arca.fiocruz.br/handle/icict/4786610.1080/22221751.2021.1932608National Institutes of Health [AI 094577].Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil.University of Pennsylvania. Department of Pathobiology. Philadelphia, PA, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil.University of Pennsylvania. Department of Pathobiology. Philadelphia, PA, USA.University of Pennsylvania. Department of Pathobiology. Philadelphia, PA, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil.Cutaneous leishmaniasis (CL) patients present an exacerbated inflammatory response associated with tissue damage and ulcer development. Increasing numbers of patients have exhibited treatment failure, which remains not well understood. We hypothesized that adjuvant anti-inflammatory therapy would benefit CL patients. The aim of the present study was to investigate the contribution of Notch signalling and gamma-secretase activity to the inflammatory response observed in CL patients. Notch signalling is a molecular signalling pathway conserved among animal species. Gamma-secretase forms a complex of proteins that, among other pathways, modulates Notch signalling and immune response. We found that Notch 1 cell receptor signalling protects against the pathologic inflammatory response, and JLK6, a gamma-secretase inhibitor that does not interfere with Notch signalling, was shown to decrease the in-vitro inflammatory response in CL. Our data suggest that JLK6 may serve as an adjuvant treatment for CL patients.engTaylor & Francis Open AccessLeishmaniose cutâneaFalhas de tratamentoCitocinasResposta inflamatóriaLeishmania braziliensisCutaneous leishmaniasisNotch signallingCytokinesInflammatory responseLeishmania braziliensisInhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/47866/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNascimento, Mauricio T Inhibition....pdfNascimento, Mauricio T 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dc.title.en.fl_str_mv Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis
title Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis
spellingShingle Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis
Nascimento, Maurício T.
Leishmaniose cutânea
Falhas de tratamento
Citocinas
Resposta inflamatória
Leishmania braziliensis
Cutaneous leishmaniasis
Notch signalling
Cytokines
Inflammatory response
Leishmania braziliensis
title_short Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis
title_full Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis
title_fullStr Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis
title_full_unstemmed Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis
title_sort Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis
author Nascimento, Maurício T.
author_facet Nascimento, Maurício T.
Franca, Mônica
Carvalho, Augusto M.
Amorim, Camila F.
Peixoto, Fábio
Beiting, Daniel
Scott, Phillip
Carvalho, Edgar Marcelino
Carvalho, Lucas Pedreira
author_role author
author2 Franca, Mônica
Carvalho, Augusto M.
Amorim, Camila F.
Peixoto, Fábio
Beiting, Daniel
Scott, Phillip
Carvalho, Edgar Marcelino
Carvalho, Lucas Pedreira
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento, Maurício T.
Franca, Mônica
Carvalho, Augusto M.
Amorim, Camila F.
Peixoto, Fábio
Beiting, Daniel
Scott, Phillip
Carvalho, Edgar Marcelino
Carvalho, Lucas Pedreira
dc.subject.other.pt_BR.fl_str_mv Leishmaniose cutânea
Falhas de tratamento
Citocinas
Resposta inflamatória
Leishmania braziliensis
topic Leishmaniose cutânea
Falhas de tratamento
Citocinas
Resposta inflamatória
Leishmania braziliensis
Cutaneous leishmaniasis
Notch signalling
Cytokines
Inflammatory response
Leishmania braziliensis
dc.subject.en.en.fl_str_mv Cutaneous leishmaniasis
Notch signalling
Cytokines
Inflammatory response
Leishmania braziliensis
description National Institutes of Health [AI 094577].
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-25T14:08:40Z
dc.date.available.fl_str_mv 2021-06-25T14:08:40Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NASCIMENTO, Maurício T. et al. Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis. Emerging Microbes and Infections, v. 10, n. 1, 16 June 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47866
dc.identifier.issn.pt_BR.fl_str_mv 2222-1751
dc.identifier.doi.pt_BR.fl_str_mv 10.1080/22221751.2021.1932608
identifier_str_mv NASCIMENTO, Maurício T. et al. Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis. Emerging Microbes and Infections, v. 10, n. 1, 16 June 2021.
2222-1751
10.1080/22221751.2021.1932608
url https://www.arca.fiocruz.br/handle/icict/47866
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis Open Access
publisher.none.fl_str_mv Taylor & Francis Open Access
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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