Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis

Detalhes bibliográficos
Autor(a) principal: Sadigursky, Moysés
Data de Publicação: 1989
Outros Autores: von Kreuter, Betsy F., Ling, Pei-Ying, Buch, Charles A. Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5722
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Sadigursky, Moysésvon Kreuter, Betsy F.Ling, Pei-YingBuch, Charles A. Santos2012-10-23T18:07:10Z2012-10-23T18:07:10Z1989SADIGURSKY, Moysés et al. Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis. Circulation, v. 80, n. 5, p. 1269-1276, Nov. 1989.0009-7322https://www.arca.fiocruz.br/handle/icict/5722engAssociation of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Cornell University Medical College. NY, New York.Cornell University Medical College. NY, New York.Cornell University Medical College. NY, New York.Antibody F(ab')2 fragments derived from the sera of four patients with histology-proven chronic Chagas myocarditis [cF(ab')2]-complexed antibody F(ab')2 fragments of children with acute Trypanosoma cruzi infection [aF(ab')2] in significantly higher molar ratios than those measured with F(ab')2 antibody fragments of normal subjects [nF(ab')2] from nonendemic areas (p less than 0.05). Anti-idiotype [cF(ab')2 X aF(ab')2] immune-complex formation was significantly blunted by preabsorption of cF(ab')2 with porcine heart atria sarcolemma (PAMs) immobilized on sepharose beads (inhibition, mean, 78.1 +/- 2.4%, n = 4). cF(ab')2 X nF(ab')2] immune-complex formation was also inhibited by pretreatment of cF(ab')2 with PAMs (inhibition, mean, 48.7 +/- 7.5%, n = 4). The sera of three groups of subjects from a geographic zone endemic for T. cruzi infection in the northeast of Brazil were assayed for free and immune-complexed IgG anti-acute T. cruzi infection F(ab')2. The indexed levels of free IgG anti-idiotype antibody activity and levels of IgG anti-idiotype immune complexes (IC') were markedly elevated in hospitalized patients with severe, decompensated chronic Chagas myocarditis (n = 23), and their IC' indexes were significantly higher than those measured in asymptomatic seropositive subjects from a nearby endemic village of the northeast of Brazil (Moniz Ferreira, n = 92, p less than 0.001) and in healthy seronegative villagers (n = 84, p less than 0.001). There exists a strong correlation between elevated IgG anti-sarcolemma, anti-idiotype activity levels and the clinical and pathologic expression of chronic Chagas myocarditis.Anticorpos Antiidiotípicos/imunologiaAnticorpos Antiprotozoários/imunologiaCardiomiopatia Chagásica/imunologiaFragmentos Fab das Imunoglobulinas/imunologiaImunoglobulina G/imunologiaMiocardite/imunologiaAdultoAnimaisComplexo Antígeno-Anticorpo/imunologiaCriançaHumanosMiocardite/etiologiaSarcolema/imunologiaTrypanosoma cruzi/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSadigursky M Association of elevated anti....pdfSadigursky M Association of elevated anti....pdfapplication/pdf1669189https://www.arca.fiocruz.br/bitstream/icict/5722/1/Sadigursky%20M%20Association%20of%20elevated%20anti....pdf5ac4555c1bee03cb91a0cac8be5cc7dfMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5722/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTSadigursky M Association of elevated anti....pdf.txtSadigursky M Association of elevated anti....pdf.txtExtracted texttext/plain37533https://www.arca.fiocruz.br/bitstream/icict/5722/5/Sadigursky%20M%20Association%20of%20elevated%20anti....pdf.txt7d2a41e0933813cab4e00c8a8d3693b9MD55THUMBNAILSadigursky M Association of elevated anti....pdf.jpgSadigursky M Association of elevated anti....pdf.jpgGenerated Thumbnailimage/jpeg1670https://www.arca.fiocruz.br/bitstream/icict/5722/4/Sadigursky%20M%20Association%20of%20elevated%20anti....pdf.jpgeee792af2288f6038e221982250d5cc5MD54icict/57222023-03-15 14:32:57.558oai:www.arca.fiocruz.br:icict/5722TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGFzc2luYXIgZSBlbnRyZWdhciBlc3RhIGxpY2Vuw6dhLCBvL2EgU3IuL1NyYS4gKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBkbyBhdXRvcik6CgpBbyBjb25jb3JkYXIgZSBhY2VpdGFyIGVzdGEgbGljZW7Dp2Egdm9jw6ogKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyk6CgphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8uCgpiKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGUgYWNlaXRhIGFzIERpcmV0cml6ZXMgcGFyYSBvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIEZ1bmRhw6fDo28gT3N3YWxkbyBDcnV6IChGSU9DUlVaKS4KCmMpIENvbmNlZGUgw6AgRklPQ1JVWiBvIGRpcmVpdG8gbsOjby1leGNsdXNpdm8gZGUgYXJxdWl2YXIsIHJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhIHNlZ3VpciksIGNvbXVuaWNhcgogCmUvb3UgZGlzdHJpYnVpciBubyBSZXBvc2l0w7NyaW8gZGEgRklPQ1JVWiwgbyBkb2N1bWVudG8gZW50cmVndWUgKGluY2x1aW5kbyBvIHJlc3Vtby9hYnN0cmFjdCkgZW0gZm9ybWF0byBkaWdpdGFsIG91IAoKcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uCgpkKSBEZWNsYXJhIHF1ZSBhdXRvcml6YSBhIEZJT0NSVVogYSBhcnF1aXZhciBtYWlzIGRlIHVtYSBjw7NwaWEgZGVzdGUgZG9jdW1lbnRvIGUgY29udmVydMOqLWxvLCBzZW0gYWx0ZXJhciBvIHNldSBjb250ZcO6ZG8sIAoKcGFyYSBxdWFscXVlciBmb3JtYXRvIGRlIGFycXVpdm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uCgplKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBzdWJtZXRpZG8gw6kgbyBzZXUgdHJhYmFsaG8gb3JpZ2luYWwsIGUgcXVlIGRldMOpbSBvIGRpcmVpdG8gZGUgY29uY2VkZXIgYSB0ZXJjZWlyb3Mgb3MgZGlyZWl0b3MgCgpjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2Ugb3MgZGlyZWl0b3MgZGUgcXVhbHF1ZXIgb3V0cmEgcGVzc29hIG91IGVudGlkYWRlLgoKZikgRGVjbGFyYSBxdWUsIG5vIGNhc28gZG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyBjb250ZXIgbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgb2J0ZXZlIGEgYXV0b3JpemHDp8OjbyAKCmlycmVzdHJpdGEgZG8gcmVzcGVjdGl2byBkZXRlbnRvciBkZXNzZXMgZGlyZWl0b3MsIHBhcmEgY2VkZXIgYSBGSU9DUlVaIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgTGljZW7Dp2EgZSBhdXRvcml6YXIgYSAKCnV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyAKCm5vIHRleHRvIG91IGNvbnRlw7pkbyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpnKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSDDiSBCQVNFQURPIEVNIFRSQUJBTEhPIEZJTkFOQ0lBRE8gT1UgQVBPSUFETyBQT1IgT1VUUkEgSU5TVElUVUnDh8ODTyBRVUUgTsODTyBBIEZJT0NSVVosIERFQ0xBUkEgUVVFIENVTVBSSVUgCgpRVUFJU1FVRVIgT0JSSUdBw4fDlUVTIEVYSUdJREFTIFBFTE8gUkVTUEVDVElWTyBDT05UUkFUTyBPVSBBQ09SRE8uIEEgRklPQ1JVWiBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgCgpkaXJlaXRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUgZSBuw6NvIGZhcsOhIHF1YWxxdWVyIGFsdGVyYcOnw6NvLCBwYXJhIGFsw6ltIGRvIHByZXZpc3RvIG5hIGFsw61uZWEgYykuCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis
title Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis
spellingShingle Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis
Sadigursky, Moysés
Anticorpos Antiidiotípicos/imunologia
Anticorpos Antiprotozoários/imunologia
Cardiomiopatia Chagásica/imunologia
Fragmentos Fab das Imunoglobulinas/imunologia
Imunoglobulina G/imunologia
Miocardite/imunologia
Adulto
Animais
Complexo Antígeno-Anticorpo/imunologia
Criança
Humanos
Miocardite/etiologia
Sarcolema/imunologia
Trypanosoma cruzi/imunologia
title_short Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis
title_full Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis
title_fullStr Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis
title_full_unstemmed Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis
title_sort Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis
author Sadigursky, Moysés
author_facet Sadigursky, Moysés
von Kreuter, Betsy F.
Ling, Pei-Ying
Buch, Charles A. Santos
author_role author
author2 von Kreuter, Betsy F.
Ling, Pei-Ying
Buch, Charles A. Santos
author2_role author
author
author
dc.contributor.author.fl_str_mv Sadigursky, Moysés
von Kreuter, Betsy F.
Ling, Pei-Ying
Buch, Charles A. Santos
dc.subject.decs.pt_BR.fl_str_mv Anticorpos Antiidiotípicos/imunologia
Anticorpos Antiprotozoários/imunologia
Cardiomiopatia Chagásica/imunologia
Fragmentos Fab das Imunoglobulinas/imunologia
Imunoglobulina G/imunologia
Miocardite/imunologia
Adulto
Animais
Complexo Antígeno-Anticorpo/imunologia
Criança
Humanos
Miocardite/etiologia
Sarcolema/imunologia
Trypanosoma cruzi/imunologia
topic Anticorpos Antiidiotípicos/imunologia
Anticorpos Antiprotozoários/imunologia
Cardiomiopatia Chagásica/imunologia
Fragmentos Fab das Imunoglobulinas/imunologia
Imunoglobulina G/imunologia
Miocardite/imunologia
Adulto
Animais
Complexo Antígeno-Anticorpo/imunologia
Criança
Humanos
Miocardite/etiologia
Sarcolema/imunologia
Trypanosoma cruzi/imunologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 1989
dc.date.issued.fl_str_mv 1989
dc.date.accessioned.fl_str_mv 2012-10-23T18:07:10Z
dc.date.available.fl_str_mv 2012-10-23T18:07:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv SADIGURSKY, Moysés et al. Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis. Circulation, v. 80, n. 5, p. 1269-1276, Nov. 1989.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5722
dc.identifier.issn.none.fl_str_mv 0009-7322
identifier_str_mv SADIGURSKY, Moysés et al. Association of elevated anti-sarcolemma, anti-idiotype antibody levels with the clinical and pathologic expression of chronic Chagas myocarditis. Circulation, v. 80, n. 5, p. 1269-1276, Nov. 1989.
0009-7322
url https://www.arca.fiocruz.br/handle/icict/5722
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