Chemical and biological analyses of the essential oils and main constituents of Piper species

Detalhes bibliográficos
Autor(a) principal: Carmo, Dominique F. Moura do
Data de Publicação: 2012
Outros Autores: Amaral, Ana Cláudia Fernandes, Machado, Gérzia M. C., Leon, Leonor Laura, Silva, Jefferson Rocha de Andrade
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30568
Resumo: Universidade Federal do Amazonas. Departamento de Química. Laboratório de Cromatografia. Manaus, AM, Brasil.
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spelling Carmo, Dominique F. Moura doAmaral, Ana Cláudia FernandesMachado, Gérzia M. C.Leon, Leonor LauraSilva, Jefferson Rocha de Andrade2018-12-13T12:44:57Z2018-12-13T12:44:57Z2012CARMO, Dominique F. Moura do; et al. Chemical and Biological Analyses of the Essential Oils and Main Constituents of Piper Species. Molecules, v.17, p.1819-1829, 2012.1420-3049https://www.arca.fiocruz.br/handle/icict/3056810.3390/molecules17021819engMDPILeishmanioseÓleo essencialAnálises clínicasAnálises biológicasPiper duckeiPiper demeraranumessential oilLeishmaniasisHET-CAMChemical and biological analyses of the essential oils and main constituents of Piper speciesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Amazonas. Departamento de Química. Laboratório de Cromatografia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Farmanguinhos. Departamento de Produtos Naturais. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.Universidade Federal do Amazonas. Departamento de Química. Laboratório de Cromatografia. Manaus, AM, Brasil.The essential oils obtained from leaves of Piper duckei and Piper demeraranum by hydrodistillation were analyzed by gas chromatography-mass spectrometry. The main constituents found in P. demeraranum oil were limonene (19.3%) and β-elemene (33.1%) and in P. duckei oil the major components found were germacrene D (14.7%) and trans-caryophyllene (27.1%). P. demeraranum and P. duckei oils exhibited biological activity, with IC(50) values between 15 to 76 μg mL(-1) against two Leishmania species, P. duckei oil being the most active. The cytotoxicity of the essential oils on mice peritoneal macrophage cells was insignificant, compared with the toxicity of pentamidine. The main mono- and sesquiterpene, limonene (IC(50) = 278 μM) and caryophyllene (IC(50) = 96 μM), were tested against the strains of Leishmania amazonensis, and the IC(50) values of these compounds were lower than those found for the essential oils of the Piper species. The HET-CAM test was used to evaluate the irritation potential of these oils as topical products, showing that these oils can be used as auxiliary medication in cases of cutaneous leishmaniasis, with less side effects and lower costs.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30568/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALleonorlaura_leon_etal_IOC_2012.pdfleonorlaura_leon_etal_IOC_2012.pdfapplication/pdf191859https://www.arca.fiocruz.br/bitstream/icict/30568/2/leonorlaura_leon_etal_IOC_2012.pdf17208165b9e527867445ff6a6029e15eMD52TEXTleonorlaura_leon_etal_IOC_2012.pdf.txtleonorlaura_leon_etal_IOC_2012.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Chemical and biological analyses of the essential oils and main constituents of Piper species
title Chemical and biological analyses of the essential oils and main constituents of Piper species
spellingShingle Chemical and biological analyses of the essential oils and main constituents of Piper species
Carmo, Dominique F. Moura do
Leishmaniose
Óleo essencial
Análises clínicas
Análises biológicas
Piper duckei
Piper demeraranum
essential oil
Leishmaniasis
HET-CAM
title_short Chemical and biological analyses of the essential oils and main constituents of Piper species
title_full Chemical and biological analyses of the essential oils and main constituents of Piper species
title_fullStr Chemical and biological analyses of the essential oils and main constituents of Piper species
title_full_unstemmed Chemical and biological analyses of the essential oils and main constituents of Piper species
title_sort Chemical and biological analyses of the essential oils and main constituents of Piper species
author Carmo, Dominique F. Moura do
author_facet Carmo, Dominique F. Moura do
Amaral, Ana Cláudia Fernandes
Machado, Gérzia M. C.
Leon, Leonor Laura
Silva, Jefferson Rocha de Andrade
author_role author
author2 Amaral, Ana Cláudia Fernandes
Machado, Gérzia M. C.
Leon, Leonor Laura
Silva, Jefferson Rocha de Andrade
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carmo, Dominique F. Moura do
Amaral, Ana Cláudia Fernandes
Machado, Gérzia M. C.
Leon, Leonor Laura
Silva, Jefferson Rocha de Andrade
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Óleo essencial
Análises clínicas
Análises biológicas
topic Leishmaniose
Óleo essencial
Análises clínicas
Análises biológicas
Piper duckei
Piper demeraranum
essential oil
Leishmaniasis
HET-CAM
dc.subject.en.pt_BR.fl_str_mv Piper duckei
Piper demeraranum
essential oil
Leishmaniasis
HET-CAM
description Universidade Federal do Amazonas. Departamento de Química. Laboratório de Cromatografia. Manaus, AM, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2018-12-13T12:44:57Z
dc.date.available.fl_str_mv 2018-12-13T12:44:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARMO, Dominique F. Moura do; et al. Chemical and Biological Analyses of the Essential Oils and Main Constituents of Piper Species. Molecules, v.17, p.1819-1829, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30568
dc.identifier.issn.pt_BR.fl_str_mv 1420-3049
dc.identifier.doi.none.fl_str_mv 10.3390/molecules17021819
identifier_str_mv CARMO, Dominique F. Moura do; et al. Chemical and Biological Analyses of the Essential Oils and Main Constituents of Piper Species. Molecules, v.17, p.1819-1829, 2012.
1420-3049
10.3390/molecules17021819
url https://www.arca.fiocruz.br/handle/icict/30568
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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