Evaluation of new potential compounds for the treatment of chromoblastomycosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo de conferência |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46027 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. |
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Coelho, Rowena AlvesLuna, Sobrino JoffeFigueiredo-Carvalho, Maria Helena GaldinoBrito-Santos, FábioRodrigues, Márcio LourençoAlmeida-Paes, Rodrigo2021-02-09T22:53:52Z2021-02-09T22:53:52Z2019COELHO, Rowena Alves et al. Evaluation of new potential compounds for the treatment of chromoblastomycosis. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 30., 2019, Maceió-Alagoas. 1 p.https://www.arca.fiocruz.br/handle/icict/46027engCromoblastomicoseAtividade antifúngicaPathogen BoxChromoblastomycosisAntifungal activityPathogen BoxEvaluation of new potential compounds for the treatment of chromoblastomycosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Stony Brook University. Department of Microbiology and Immunology. New York, NY, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de regulação da expressão gênica. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Chromoblastomycosis (CBM) is a chronic fungal infection of the cutaneous and subcutaneous tissue caused by traumatic implantation, had black fungi of several species as etiological agents. This disease is considered an occupational disease that mainly affects professions related to the handling of soil like the agricultural sector, of civil construction, exposed to contaminated vegetable materials. The most common CBM agents are Fonsecaea species, Phialophora verrucosa, Cladophialophora carrionii, Rhinocladiella aquaspersa, Rhinocladiella similis, Exophiala dermatitidis, Exophiala jeanselmei and others. There is no standard of CBM treatment to follow, requiring more than one drug to be administered and physical methods in most cases. Itraconazole (ITZ) and terbinafine (TRB) are the drugs most commonly used. There are few antifungals that can be used in the treatment of CBM, the refractoriness of some cases and potential recurrences this mycosis, a preclinical study involving compounds already established for other diseases and with known cytotoxicity will allow an evaluation of potential new drugs that may be included in clinical trials for the treatment of CBM in the future. Thus, the objective of this study was to evaluate the antifungal activity of 400 molecules present in Pathogen box against CBM agents. The initial screening with Fonsecaea pedrosoi strain highlighted two compounds: MMV021013 and MMV688978 that presented MIC values between 1.25-5µM and 1.25-2.5µM, respectively, against different CBM agents. The in vitro MIC determination was followed by EUCAST protocol. The analysis of potential synergism of these compounds with the drugs already used in the treatment of this disease (ITZ and TRB) was also be performed. Through these results will can to selected compounds that may be used as promising drugs in the treatment or prophylaxis of CBM in the future.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALRowena Coelho.pdfRowena Coelho.pdfapplication/pdf491453https://www.arca.fiocruz.br/bitstream/icict/46027/2/Rowena%20Coelho.pdff0612fb8d2289d93cdf34e1ef280bf11MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46027/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTRowena Coelho.pdf.txtRowena Coelho.pdf.txtExtracted texttext/plain5035https://www.arca.fiocruz.br/bitstream/icict/46027/4/Rowena%20Coelho.pdf.txt6d4be006501920589a0ff8bd840ad6c8MD54icict/460272021-02-10 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| dc.title.pt_BR.fl_str_mv |
Evaluation of new potential compounds for the treatment of chromoblastomycosis |
| title |
Evaluation of new potential compounds for the treatment of chromoblastomycosis |
| spellingShingle |
Evaluation of new potential compounds for the treatment of chromoblastomycosis Coelho, Rowena Alves Cromoblastomicose Atividade antifúngica Pathogen Box Chromoblastomycosis Antifungal activity Pathogen Box |
| title_short |
Evaluation of new potential compounds for the treatment of chromoblastomycosis |
| title_full |
Evaluation of new potential compounds for the treatment of chromoblastomycosis |
| title_fullStr |
Evaluation of new potential compounds for the treatment of chromoblastomycosis |
| title_full_unstemmed |
Evaluation of new potential compounds for the treatment of chromoblastomycosis |
| title_sort |
Evaluation of new potential compounds for the treatment of chromoblastomycosis |
| author |
Coelho, Rowena Alves |
| author_facet |
Coelho, Rowena Alves Luna, Sobrino Joffe Figueiredo-Carvalho, Maria Helena Galdino Brito-Santos, Fábio Rodrigues, Márcio Lourenço Almeida-Paes, Rodrigo |
| author_role |
author |
| author2 |
Luna, Sobrino Joffe Figueiredo-Carvalho, Maria Helena Galdino Brito-Santos, Fábio Rodrigues, Márcio Lourenço Almeida-Paes, Rodrigo |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Coelho, Rowena Alves Luna, Sobrino Joffe Figueiredo-Carvalho, Maria Helena Galdino Brito-Santos, Fábio Rodrigues, Márcio Lourenço Almeida-Paes, Rodrigo |
| dc.subject.other.pt_BR.fl_str_mv |
Cromoblastomicose Atividade antifúngica Pathogen Box |
| topic |
Cromoblastomicose Atividade antifúngica Pathogen Box Chromoblastomycosis Antifungal activity Pathogen Box |
| dc.subject.en.pt_BR.fl_str_mv |
Chromoblastomycosis Antifungal activity Pathogen Box |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. |
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2019 |
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2019 |
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2021-02-09T22:53:52Z |
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2021-02-09T22:53:52Z |
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COELHO, Rowena Alves et al. Evaluation of new potential compounds for the treatment of chromoblastomycosis. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 30., 2019, Maceió-Alagoas. 1 p. |
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https://www.arca.fiocruz.br/handle/icict/46027 |
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COELHO, Rowena Alves et al. Evaluation of new potential compounds for the treatment of chromoblastomycosis. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 30., 2019, Maceió-Alagoas. 1 p. |
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