The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49709 |
Resumo: | King Abdullah University of Science and Technology. Biological and Environmental Sciences and Engineering. Pathogen Genomics Laboratory. Thuwal, Saudi Arabia. |
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Mourier, TobiasAlvarenga, Denise Anete Madureira deKaushik, AbhinavCosta, Anielle de PinaDouvropoulou, OlgaGuan, QingtianGuzmán-Vega, Francisco J.Forrester, SarahAbreu, Filipe Vieira Santos deBianco Júnior, CesareSouza Junior, Julio Cesar deMoreira, Silvia BahadianHirano, Zelinda Maria BragaPissinatti, AlcidesCruz, Maria de Fátima Ferreira daOliveira, Ricardo Lourenço deArold, Stefan T.Jeffares, Daniel C.Brasil, PatríciaBrito, Cristiana Ferreira Alves deCulleton, RichardRibeiro, Cláudio Tadeu DanielPain, Arnab2021-11-05T14:32:43Z2021-11-05T14:32:43Z2021MOURIER, Tobias et al. The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching. BMC Biology, v. 19, n. 219, p. 1-17, 1 Oct. 2021.1741-7007https://www.arca.fiocruz.br/handle/icict/4970910.1186/s12915-021-01139-51741-7007engBMCPlasmodium simiumPlasmodium vivaxMaláriaZoonoseGenômica comparativaPlasmodium simiumPlasmodium vivaxMalariaZoonosisComparative genomicsThe genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switchinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleKing Abdullah University of Science and Technology. Biological and Environmental Sciences and Engineering. Pathogen Genomics Laboratory. Thuwal, Saudi Arabia.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.King Abdullah University of Science and Technology. Biological and Environmental Sciences and Engineering Division. Pathogen Genomics Laboratory. Thuwal, Saudi Arabia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil / Centro Universitário Serra dos Órgãos. Teresópolis, RJ, Brasil.King Abdullah University of Science and Technology. Biological and Environmental Sciences and Engineering Division. Pathogen Genomics Laboratory. Thuwal, Saudi Arabia.King Abdullah University of Science and Technology. Biological and Environmental Sciences and Engineering Division. Pathogen Genomics Laboratory. Thuwal, Saudi Arabia.King Abdullah University of Science and Technology. Biological and Environmental Sciences and Engineering Division. Computational Bioscience Research Center. Thuwal, Saudi Arabia.University of York. Department of Biology. York Biomedical Research Institute. Wentworth Way, York, UK.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Universidade Regional de Blumenau. Centro de Pesquisas Biológicas de Indaial. Projeto Bugio. Indaial, SC, Brasil.Governo do Estado do Rio de Janeiro. Instituto Estadual do Ambiente. Centro de Primatologia do Rio de Janeiro. Guapimirim, RJ, Brasil.Universidade Regional de Blumenau. Centro de Pesquisas Biológicas de Indaial. Projeto Bugio. Indaial, SC, Brasil.Governo do Estado do Rio de Janeiro. Instituto Estadual do Ambiente. Centro de Primatologia do Rio de Janeiro. Guapimirim, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.King Abdullah University of Science and Technology. Biological and Environmental Sciences and Engineering Division. Computational Bioscience Research Center. Thuwal, Saudi Arabia / Université de Montpellier. Centre de Biologie Structurale. Montpellier, France / Centre National de La Recherche Scientifique. Michel-Ange, Paris, France / Institut National de la Santé et de la Recherche Médicale. Paris, France.University of York. Department of Biology. York Biomedical Research Institute. Wentworth Way, York, UK.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Ehime University. Proteo-Science Center. Division of Molecular Parasitology. Toon, Ehime, Japan.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.King Abdullah University of Science and Technology. Biological and Environmental Sciences and Engineering Division. Pathogen Genomics Laboratory. Thuwal, Saudi Arabia / Hokkaido University. Global Station for Zoonosis Control. Kita-ku, Sapporo, Japan / Hokkaido University. Global Institution for Collaborative Research and Education. Kita-ku, Sapporo, Japan.Background: Plasmodium simium, a malaria parasite of non-human primates (NHP), was recently shown to cause zoonotic infections in humans in Brazil. We sequenced the P. simium genome to investigate its evolutionary history and to identify any genetic adaptions that may underlie the ability of this parasite to switch between host species. Results: Phylogenetic analyses based on whole genome sequences of P. simium from humans and NHPs reveals that P. simium is monophyletic within the broader diversity of South American Plasmodium vivax, suggesting P. simium first infected NHPs as a result of a host switch of P. vivax from humans. The P. simium isolates show the closest relationship to Mexican P. vivax isolates. Analysis of erythrocyte invasion genes reveals differences between P. vivax and P. simium, including large deletions in the Duffy-binding protein 1 (DBP1) and reticulocyte-binding protein 2a genes of P. simium. Analysis of P. simium isolated from NHPs and humans revealed a deletion of 38 amino acids in DBP1 present in all human-derived isolates, whereas NHP isolates were multi-allelic. Conclusions: Analysis of the P. simium genome confirmed a close phylogenetic relationship between P. simium and P. vivax, and suggests a very recent American origin for P. simium. The presence of the DBP1 deletion in all human-derived isolates tested suggests that this deletion, in combination with other genetic changes in P. simium, may facilitate the invasion of human red blood cells and may explain, at least in part, the basis of the recent zoonotic infections.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49709/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRicardoLOliveira_ClaudioTDanielRibeiro_etal_IOC_2021.pdfRicardoLOliveira_ClaudioTDanielRibeiro_etal_IOC_2021.pdfapplication/pdf2247782https://www.arca.fiocruz.br/bitstream/icict/49709/2/RicardoLOliveira_ClaudioTDanielRibeiro_etal_IOC_2021.pdfcc66522ad8dd039bd98c0097ff9724faMD52icict/497092022-06-24 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| dc.title.en.fl_str_mv |
The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching |
| title |
The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching |
| spellingShingle |
The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching Mourier, Tobias Plasmodium simium Plasmodium vivax Malária Zoonose Genômica comparativa Plasmodium simium Plasmodium vivax Malaria Zoonosis Comparative genomics |
| title_short |
The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching |
| title_full |
The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching |
| title_fullStr |
The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching |
| title_full_unstemmed |
The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching |
| title_sort |
The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching |
| author |
Mourier, Tobias |
| author_facet |
Mourier, Tobias Alvarenga, Denise Anete Madureira de Kaushik, Abhinav Costa, Anielle de Pina Douvropoulou, Olga Guan, Qingtian Guzmán-Vega, Francisco J. Forrester, Sarah Abreu, Filipe Vieira Santos de Bianco Júnior, Cesare Souza Junior, Julio Cesar de Moreira, Silvia Bahadian Hirano, Zelinda Maria Braga Pissinatti, Alcides Cruz, Maria de Fátima Ferreira da Oliveira, Ricardo Lourenço de Arold, Stefan T. Jeffares, Daniel C. Brasil, Patrícia Brito, Cristiana Ferreira Alves de Culleton, Richard Ribeiro, Cláudio Tadeu Daniel Pain, Arnab |
| author_role |
author |
| author2 |
Alvarenga, Denise Anete Madureira de Kaushik, Abhinav Costa, Anielle de Pina Douvropoulou, Olga Guan, Qingtian Guzmán-Vega, Francisco J. Forrester, Sarah Abreu, Filipe Vieira Santos de Bianco Júnior, Cesare Souza Junior, Julio Cesar de Moreira, Silvia Bahadian Hirano, Zelinda Maria Braga Pissinatti, Alcides Cruz, Maria de Fátima Ferreira da Oliveira, Ricardo Lourenço de Arold, Stefan T. Jeffares, Daniel C. Brasil, Patrícia Brito, Cristiana Ferreira Alves de Culleton, Richard Ribeiro, Cláudio Tadeu Daniel Pain, Arnab |
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author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mourier, Tobias Alvarenga, Denise Anete Madureira de Kaushik, Abhinav Costa, Anielle de Pina Douvropoulou, Olga Guan, Qingtian Guzmán-Vega, Francisco J. Forrester, Sarah Abreu, Filipe Vieira Santos de Bianco Júnior, Cesare Souza Junior, Julio Cesar de Moreira, Silvia Bahadian Hirano, Zelinda Maria Braga Pissinatti, Alcides Cruz, Maria de Fátima Ferreira da Oliveira, Ricardo Lourenço de Arold, Stefan T. Jeffares, Daniel C. Brasil, Patrícia Brito, Cristiana Ferreira Alves de Culleton, Richard Ribeiro, Cláudio Tadeu Daniel Pain, Arnab |
| dc.subject.other.pt_BR.fl_str_mv |
Plasmodium simium Plasmodium vivax Malária Zoonose Genômica comparativa |
| topic |
Plasmodium simium Plasmodium vivax Malária Zoonose Genômica comparativa Plasmodium simium Plasmodium vivax Malaria Zoonosis Comparative genomics |
| dc.subject.en.en.fl_str_mv |
Plasmodium simium Plasmodium vivax Malaria Zoonosis Comparative genomics |
| description |
King Abdullah University of Science and Technology. Biological and Environmental Sciences and Engineering. Pathogen Genomics Laboratory. Thuwal, Saudi Arabia. |
| publishDate |
2021 |
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2021-11-05T14:32:43Z |
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2021-11-05T14:32:43Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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MOURIER, Tobias et al. The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching. BMC Biology, v. 19, n. 219, p. 1-17, 1 Oct. 2021. |
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https://www.arca.fiocruz.br/handle/icict/49709 |
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1741-7007 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1186/s12915-021-01139-5 |
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1741-7007 |
| identifier_str_mv |
MOURIER, Tobias et al. The genome of the zoonotic Malaria parasite Plasmodium simium reveals adaptations to host switching. BMC Biology, v. 19, n. 219, p. 1-17, 1 Oct. 2021. 1741-7007 10.1186/s12915-021-01139-5 |
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BMC |
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