Genetic variability of platelet glycoprotein Ibalpha gene
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2004 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19369 |
Resumo: | Gonçalves, Marilda de Souza “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Ozelo, Margareth CastroCosta, Devanira de Souza PaixãoSiqueira, Lucia HelenaMachado, Tania M FCastro, VagnerGonçalves, Marilda de SouzaMenezes, Raimundo CSoares, ManoelBizzacchi, Joyce M AnnichinoCosta, Fernando FArruda, Valder Roberval2017-06-12T16:12:55Z2017-06-12T16:12:55Z2004OZELO, M. C. et al. Genetic variability of platelet glycoprotein Ibalpha gene. American Journal of Hematology, v. 77, p. 107–116, 2004.0361-8609https://www.arca.fiocruz.br/handle/icict/1936910.1002/ajh.20148Gonçalves, Marilda de Souza “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.State University of Campinas. Hematology and Hemotherapy Center. Campinas, SP, BrazilState University of Campinas. Hematology and Hemotherapy Center. Campinas, SP, BrazilState University of Campinas. Hematology and Hemotherapy Center. Campinas, SP, BrazilState University of Campinas. Hematology and Hemotherapy Center. Campinas, SP, BrazilState University of Campinas. Hematology and Hemotherapy Center. Campinas, SP, BrazilFederal University of Bahia. Department of Pharmacology. Salvador, BA, BrazilEvandro Chagas Institute. Belém, PA, BrazilEvandro Chagas Institute. Belém, PA, BrazilState University of Campinas. Hematology and Hemotherapy Center. Campinas, SP, BrazilState University of Campinas. Hematology and Hemotherapy Center. Campinas, SP, BrazilUniversity of Pennsylvania School of Medicine. The Children’s Hospital of Philadelphia. Department of Pediatrics. Philadelphia, PennsylvaniaPlatelet membrane glycoprotein (GP) Ibalpha is a critical component of platelet adhesion complex to subendothelium structures following tissue injury or pathological surfaces, such as atherosclerotic plaques. Polymorphisms of the GPIbalpha gene have been associated with a high risk for occlusive vascular disease, and its distribution varies considerably among distinct populations. These polymorphisms comprise the human platelet antigen (HPA)-2 system, the -5C/T dimorphism of the Kozak sequence, and the variable number of tandem 39-bp repeats (VNTR). Here we report the prevalence of the GPIbalpha gene polymorphisms among Brazilians, a highly ethnically diverse population. We analyzed 492 subjects of European, African, or Indigenous origin. It was possible to determine ten distinct haplotypes. The most common ( reverse similar 40%) haplotype was the Kozak-TT/HPA-2aa/VNTR-CC for both Caucasian and African descent. However, among Indigenous, Kozak-TT/HPA-2aa/VNTR-CC and Kozak-TC/HPA-2aa/VNTR-CC were equally present. Although a strong linkage disequilibrium between VNTR and HPA-2 polymorphism had also been observed, here we determined incomplete linkage disequilibrium in 10% of subjects from all ethnic groups. VNTR-E, a rare variant lacking the 39-bp repeat, was identified in two unrelated subjects, and functional platelet studies revealed no abnormalities. The VNTR-A allele, the largest variant containing four copies of the repeats, was not identified in this population. However, homozygosity for the VNTR-A allele (Kozak-TT/HPA-2aa/VNTR-AA) was determined in two distinct species of nonhuman primates. These results suggest a greater complex evolutionary mechanism in the macroglycoprotein region of the GPIbalpha gene and may be useful in the design of gene-disease association studies for vascular disease.engWileyGlicoproteína Ib alfaPolimorfismoPlaquetasDiversidade genéticaGlycoprotein Ib alphaPolymorphismsPlateletGenetic diversityGlicoproteínaPolimorfismoPlaquetasDiversidade genéticaGenetic variability of platelet glycoprotein Ibalpha geneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19369/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOzelo MC Genetic variability....pdfOzelo MC Genetic variability....pdfapplication/pdf293091https://www.arca.fiocruz.br/bitstream/icict/19369/2/Ozelo%20MC%20Genetic%20variability....pdfe089220c0c4c5031276f07c911d932b3MD52TEXTOzelo MC Genetic variability....pdf.txtOzelo MC Genetic variability....pdf.txtExtracted texttext/plain39087https://www.arca.fiocruz.br/bitstream/icict/19369/3/Ozelo%20MC%20Genetic%20variability....pdf.txt0004289b5b72a8c090f7fc38df9bf569MD53icict/193692023-03-15 14:34:04.892oai:www.arca.fiocruz.br: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ório 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| dc.title.pt_BR.fl_str_mv |
Genetic variability of platelet glycoprotein Ibalpha gene |
| title |
Genetic variability of platelet glycoprotein Ibalpha gene |
| spellingShingle |
Genetic variability of platelet glycoprotein Ibalpha gene Ozelo, Margareth Castro Glicoproteína Ib alfa Polimorfismo Plaquetas Diversidade genética Glycoprotein Ib alpha Polymorphisms Platelet Genetic diversity Glicoproteína Polimorfismo Plaquetas Diversidade genética |
| title_short |
Genetic variability of platelet glycoprotein Ibalpha gene |
| title_full |
Genetic variability of platelet glycoprotein Ibalpha gene |
| title_fullStr |
Genetic variability of platelet glycoprotein Ibalpha gene |
| title_full_unstemmed |
Genetic variability of platelet glycoprotein Ibalpha gene |
| title_sort |
Genetic variability of platelet glycoprotein Ibalpha gene |
| author |
Ozelo, Margareth Castro |
| author_facet |
Ozelo, Margareth Castro Costa, Devanira de Souza Paixão Siqueira, Lucia Helena Machado, Tania M F Castro, Vagner Gonçalves, Marilda de Souza Menezes, Raimundo C Soares, Manoel Bizzacchi, Joyce M Annichino Costa, Fernando F Arruda, Valder Roberval |
| author_role |
author |
| author2 |
Costa, Devanira de Souza Paixão Siqueira, Lucia Helena Machado, Tania M F Castro, Vagner Gonçalves, Marilda de Souza Menezes, Raimundo C Soares, Manoel Bizzacchi, Joyce M Annichino Costa, Fernando F Arruda, Valder Roberval |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ozelo, Margareth Castro Costa, Devanira de Souza Paixão Siqueira, Lucia Helena Machado, Tania M F Castro, Vagner Gonçalves, Marilda de Souza Menezes, Raimundo C Soares, Manoel Bizzacchi, Joyce M Annichino Costa, Fernando F Arruda, Valder Roberval |
| dc.subject.other.pt_BR.fl_str_mv |
Glicoproteína Ib alfa Polimorfismo Plaquetas Diversidade genética |
| topic |
Glicoproteína Ib alfa Polimorfismo Plaquetas Diversidade genética Glycoprotein Ib alpha Polymorphisms Platelet Genetic diversity Glicoproteína Polimorfismo Plaquetas Diversidade genética |
| dc.subject.en.pt_BR.fl_str_mv |
Glycoprotein Ib alpha Polymorphisms Platelet Genetic diversity |
| dc.subject.decs.pt_BR.fl_str_mv |
Glicoproteína Polimorfismo Plaquetas Diversidade genética |
| description |
Gonçalves, Marilda de Souza “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2004 |
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2004 |
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2017-06-12T16:12:55Z |
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2017-06-12T16:12:55Z |
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OZELO, M. C. et al. Genetic variability of platelet glycoprotein Ibalpha gene. American Journal of Hematology, v. 77, p. 107–116, 2004. |
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https://www.arca.fiocruz.br/handle/icict/19369 |
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0361-8609 |
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10.1002/ajh.20148 |
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OZELO, M. C. et al. Genetic variability of platelet glycoprotein Ibalpha gene. American Journal of Hematology, v. 77, p. 107–116, 2004. 0361-8609 10.1002/ajh.20148 |
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