Increased Lung Immune Metabolic Activity in COVID-19 Survivors

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Rosana Souza
Data de Publicação: 2022
Outros Autores: Ribeiro, Gabriel Motta, Barreto, Miriam Menna, Zin, Walter Araujo, Mendes, Júlia de Toledo, Martins, Philippe Alcantara G., Almeida, Sergio Altino de, Basílio, Rodrigo, Gonçalves, Remy Martins, Hotz, Eugênio Damaceno, Bozza, Patricia T., Bozza, Fernando A., Carvalho, Alysson Roncally Silva, Castro, Paulo Henrique Rosado de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55889
Resumo: Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Radiologia. Rio de Janeiro, RJ, Brasil.
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spelling Rodrigues, Rosana SouzaRibeiro, Gabriel MottaBarreto, Miriam MennaZin, Walter AraujoMendes, Júlia de ToledoMartins, Philippe Alcantara G.Almeida, Sergio Altino deBasílio, RodrigoGonçalves, Remy MartinsHotz, Eugênio DamacenoBozza, Patricia T.Bozza, Fernando A.Carvalho, Alysson Roncally SilvaCastro, Paulo Henrique Rosado de2022-12-04T20:59:16Z2022-12-04T20:59:16Z2022RODRIGUES, Rosana Souza et al. Increased Lung Immune Metabolic Activity in COVID-19 Survivors. Clinical Nuclear Medicine, v. 47, n. 12, p. 1 - 7, Dec. 2022.1536-0229https://www.arca.fiocruz.br/handle/icict/5588910.1097/RLU.0000000000004376engWolters Kluwer Health, IncCOVID-19PneumoniaAtivação de células endoteliaisImunometabolismoCOVID longaPET/CTInflamação pulmonarCOVID-19PneumoniaEndothelial cell activationImmunometabolismlong COVIDPET/CTPulmonary inflammationIncreased Lung Immune Metabolic Activity in COVID-19 Survivorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Radiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Alberto Luiz Coimbra Institute of Post-Graduation and Research in Engineering. Laboratory of Pulmonary Engineering, Biomedical Engineering Program. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Laboratório de Fisiologia Respiratória. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica. Carlos Chagas Filho. Laboratorio de Fisiologia Respiratória. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Radiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Radiologia. Rio de Janeiro, RJ, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, BrasilInstituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal de Juiz de Fora. Departamento de Bioquímica. Laboratório de Imunotrombose. Juiz de Fora. MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.D'Or Institute for Research and Education, Rio de Janeiro, Brazil.D'Or Institute for Research and Education, Rio de Janeiro, Brasil. Universidade Federal do Rio de Janeiro. Departamento de Radiologia. Rio de Janeiro, RJ, Brasil.D'Or Institute for Research and Education, Rio de Janeiro, Brazil / Universidade Federal do Rio de Janeiro. Departamento de Radiologia. Rio de Janeiro, RJ, Brasil.Purpose: We quantified lung glycolytic metabolic activity, clinical symptoms and inflammation, coagulation, and endothelial activation biomarkers in 2019 coronavirus disease (COVID-19) pneumonia survivors. Methods: Adults previously hospitalized with moderate to severe COVID-19 pneumonia were prospectively included. Subjects filled out a questionnaire on clinical consequences, underwent chest CTand 18F-FDG PET/CT, and provided blood samples on the same day. Forty-five volunteers served as control subjects. Analysis of CTimages and quantitative voxel-based analysis of PET/CTimages were performed for both groups. 18F-FDGuptake in thewhole-lung volume and in high- and low-attenuation areaswas calculated and normalized to liver values. Quantification of plasma markers of inflammation (interleukin 6), D-dimer, and endothelial cell activation (angiopoietins 1 and 2, vascular cell adhesion molecule 1, and intercellular adhesion molecule 1) was also performed. Results: We enrolled 53 COVID-19 survivors (62.3% were male; median age, 50 years). All survivors reported at least 1 persistent symptom, and 41.5% reported more than 6 symptoms. The mean lung density was greater in survivors than in control subjects, and more metabolic activity was observed in normal and dense lung areas, even months after symptom onset. Plasma proinflammatory proinflammatory, coagulation, and endothelial activation biomarker concentrations were also significantly higher in survivors. Conclusion:We observed more metabolic activity in areas of high and normal lung attenuation several months after moderate to severe COVID-19 pneumonia. In addition, plasma markers of thromboinflammation and endothelial activation persisted. These findings may have implications for our understanding of the in vivo pathogenesis and long-lasting effects of COVID-19 pneumonia.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALRemiGonçalves_PatriciaBozza_etal_IOC_2022.pdfRemiGonçalves_PatriciaBozza_etal_IOC_2022.pdfapplication/pdf909658https://www.arca.fiocruz.br/bitstream/icict/55889/2/RemiGon%c3%a7alves_PatriciaBozza_etal_IOC_2022.pdf67b1e6e54e0372ea5f3f10a7ec5c49feMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55889/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/558892023-09-14 15:46:57.281oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T18:46:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Increased Lung Immune Metabolic Activity in COVID-19 Survivors
title Increased Lung Immune Metabolic Activity in COVID-19 Survivors
spellingShingle Increased Lung Immune Metabolic Activity in COVID-19 Survivors
Rodrigues, Rosana Souza
COVID-19
Pneumonia
Ativação de células endoteliais
Imunometabolismo
COVID longa
PET/CT
Inflamação pulmonar
COVID-19
Pneumonia
Endothelial cell activation
Immunometabolism
long COVID
PET/CT
Pulmonary inflammation
title_short Increased Lung Immune Metabolic Activity in COVID-19 Survivors
title_full Increased Lung Immune Metabolic Activity in COVID-19 Survivors
title_fullStr Increased Lung Immune Metabolic Activity in COVID-19 Survivors
title_full_unstemmed Increased Lung Immune Metabolic Activity in COVID-19 Survivors
title_sort Increased Lung Immune Metabolic Activity in COVID-19 Survivors
author Rodrigues, Rosana Souza
author_facet Rodrigues, Rosana Souza
Ribeiro, Gabriel Motta
Barreto, Miriam Menna
Zin, Walter Araujo
Mendes, Júlia de Toledo
Martins, Philippe Alcantara G.
Almeida, Sergio Altino de
Basílio, Rodrigo
Gonçalves, Remy Martins
Hotz, Eugênio Damaceno
Bozza, Patricia T.
Bozza, Fernando A.
Carvalho, Alysson Roncally Silva
Castro, Paulo Henrique Rosado de
author_role author
author2 Ribeiro, Gabriel Motta
Barreto, Miriam Menna
Zin, Walter Araujo
Mendes, Júlia de Toledo
Martins, Philippe Alcantara G.
Almeida, Sergio Altino de
Basílio, Rodrigo
Gonçalves, Remy Martins
Hotz, Eugênio Damaceno
Bozza, Patricia T.
Bozza, Fernando A.
Carvalho, Alysson Roncally Silva
Castro, Paulo Henrique Rosado de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Rosana Souza
Ribeiro, Gabriel Motta
Barreto, Miriam Menna
Zin, Walter Araujo
Mendes, Júlia de Toledo
Martins, Philippe Alcantara G.
Almeida, Sergio Altino de
Basílio, Rodrigo
Gonçalves, Remy Martins
Hotz, Eugênio Damaceno
Bozza, Patricia T.
Bozza, Fernando A.
Carvalho, Alysson Roncally Silva
Castro, Paulo Henrique Rosado de
dc.subject.other.en_US.fl_str_mv COVID-19
Pneumonia
Ativação de células endoteliais
Imunometabolismo
COVID longa
PET/CT
Inflamação pulmonar
topic COVID-19
Pneumonia
Ativação de células endoteliais
Imunometabolismo
COVID longa
PET/CT
Inflamação pulmonar
COVID-19
Pneumonia
Endothelial cell activation
Immunometabolism
long COVID
PET/CT
Pulmonary inflammation
dc.subject.en.en_US.fl_str_mv COVID-19
Pneumonia
Endothelial cell activation
Immunometabolism
long COVID
PET/CT
Pulmonary inflammation
description Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Radiologia. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-12-04T20:59:16Z
dc.date.available.fl_str_mv 2022-12-04T20:59:16Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Rosana Souza et al. Increased Lung Immune Metabolic Activity in COVID-19 Survivors. Clinical Nuclear Medicine, v. 47, n. 12, p. 1 - 7, Dec. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55889
dc.identifier.issn.en_US.fl_str_mv 1536-0229
dc.identifier.doi.none.fl_str_mv 10.1097/RLU.0000000000004376
identifier_str_mv RODRIGUES, Rosana Souza et al. Increased Lung Immune Metabolic Activity in COVID-19 Survivors. Clinical Nuclear Medicine, v. 47, n. 12, p. 1 - 7, Dec. 2022.
1536-0229
10.1097/RLU.0000000000004376
url https://www.arca.fiocruz.br/handle/icict/55889
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wolters Kluwer Health, Inc
publisher.none.fl_str_mv Wolters Kluwer Health, Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55889/2/RemiGon%c3%a7alves_PatriciaBozza_etal_IOC_2022.pdf
https://www.arca.fiocruz.br/bitstream/icict/55889/1/license.txt
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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