Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study

Detalhes bibliográficos
Autor(a) principal: Martinez, Viviana Fajardo
Data de Publicação: 2023
Outros Autores: Zhang, Dajie, Paiola, Sophia, Mok, Thalia, Cambou, Mary C., Kerin, Tara, Rao, Rashmi, Brasil, Patricia, Ferreira, Fatima, Fuller, Trevon, Bhattacharya, Debika, Foo, Suan-Sin, Chen, Weiqiang, Jung, Jae, Einspieler, Christa, Marschik, Peter B., Nielsen-Saines, Karin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58409
Resumo: Ethics approval The study was approved by Institutional review boards at UCLA (IRB protocol 20-000569) and Fundação Oswaldo Cruz (Fiocruz/National Ethics Committee CONEP 30639420.0.0000.5262) with informed consent obtained from parents.
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spelling Martinez, Viviana FajardoZhang, DajiePaiola, SophiaMok, ThaliaCambou, Mary C.Kerin, TaraRao, RashmiBrasil, PatriciaFerreira, FatimaFuller, TrevonBhattacharya, DebikaFoo, Suan-SinChen, WeiqiangJung, JaeEinspieler, ChristaMarschik, Peter B.Nielsen-Saines, Karin2023-05-15T23:27:35Z2023-05-15T23:27:35Z2023MARTINEZ, Viviana Fajardo et al. Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study. BMJ Open, v. 13, n. 1, p. 1-9, Jan. 2023.2044-6055https://www.arca.fiocruz.br/handle/icict/5840910.1136/bmjopen-2022-0691942044-6055Ethics approval The study was approved by Institutional review boards at UCLA (IRB protocol 20-000569) and Fundação Oswaldo Cruz (Fiocruz/National Ethics Committee CONEP 30639420.0.0000.5262) with informed consent obtained from parents.Simons Foundation Autism Research Initiative (SFARI) (award number 866410 to KN-S); the UCLA W.M. Keck Foundation COVID19 Research Award Programme (award number not available to KN-S) the National Institutes of Health (award number T32MH080634 to MCC; award number AI140718 to KN-S).University of California Los Angeles. Pediatrics, David Geffen School of Medicine. Los Angeles, CA, USA.University Medical Center Göttingen and Leibniz-ScienceCampus Primate Cognition. Child and Adolescent Psychiatry and Psychotherapy. Göttingen, Germany / iDN - interdisciplinary Developmental Neuroscience. Division of Phoniatrics. Medical University of Graz. Graz, Austria.University of California Los Angeles. Pediatrics, David Geffen School of Medicine. Los Angeles, CA, USA.University of California Los Angeles. David Geffen School of Medicine. Obstetrics and Gynecology. Los Angeles, CA, USA.University of California Los Angeles. David Geffen School of Medicine. Internal Medicine. Los Angeles, CA, USA.University of California Los Angeles. Pediatrics, David Geffen School of Medicine. Los Angeles, CA, USA.University of California Los Angeles. David Geffen School of Medicine. Obstetrics and Gynecology. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Acute Febrile Illnesses. Rio de Janeiro, RJ, Brazil.Universidade do Rio de Janeiro. Escola de Medicina. Pediatrics. Rio de Janeiro, RJ, Brazil.University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.University of California Los Angeles. David Geffen School of Medicine. Internal Medicine. Los Angeles, CA, USA.Cancer Biology, Lerner Research Institute. Cleveland Clinic. Cleveland, Ohio, USA.Cancer Biology, Lerner Research Institute. Cleveland Clinic. Cleveland, Ohio, USA.Cancer Biology, Lerner Research Institute. Cleveland Clinic. Cleveland, Ohio, USA.iDN - interdisciplinary Developmental Neuroscience. Division of Phoniatrics. Medical University of Graz. Graz, Austria.University Medical Center Göttingen and Leibniz-ScienceCampus Primate Cognition. Child and Adolescent Psychiatry and Psychotherapy. Göttingen, Germany / iDN - interdisciplinary Developmental Neuroscience. Division of Phoniatrics. Medical University of Graz. Graz, Austria / Center of Neurodevelopmental Disorders. Centre for Psychiatry Research; Department of Women's and Children's Health. Karolinska Institutet. Stockholm, Sweden.University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA.Objective: To evaluate neuromotor repertoires and developmental milestones in infants exposed to antenatal COVID-19. Design: Longitudinal cohort study. Setting: Hospital-based study in Los Angeles, USA and Rio de Janeiro, Brazil between March 2020 and December 2021. Participants: Infants born to mothers with COVID-19 during pregnancy and prepandemic control infants from the Graz University Database. Interventions: General movement assessment (GMA) videos between 3 and 5 months post-term age were collected and clinical assessments/developmental milestones evaluated at 6-8 months of age. Cases were matched by gestational age, gender and post-term age to prepandemic neurotypical unexposed controls from the database. Main outcome measures: Motor Optimality Scores Revised (MOS-R) at 3-5 months. Presence of developmental delay (DD) at 6-8 months. Results: 239 infants were enrolled; 124 cases (83 in the USA/41 in Brazil) and 115 controls. GMA was assessed in 115 cases and 115 controls; 25% were preterm. Median MOS-R in cases was 23 (IQR 21-24, range 9-28) vs 25 (IQR 24-26, range 20-28) in controls, p<0.001. Sixteen infants (14%) had MOS-R scores <20 vs zero controls, p<0.001. At 6-8 months, 13 of 109 case infants (12%) failed to attain developmental milestones; all 115 control infants had normal development. The timing of maternal infection in pregnancy (first, second or third trimester) or COVID-19 disease severity (NIH categories asymptomatic, mild/moderate or severe/critical) was not associated with suboptimal MOS-R or DD. Maternal fever in pregnancy was associated with DD (OR 3.7; 95% CI 1.12 to 12.60) but not suboptimal MOS-R (OR 0.25; 95% CI 0.04 to 0.96). Conclusions: Compared with prepandemic controls, infants exposed to antenatal COVID-19 more frequently had suboptimal neuromotor development.engBMJ Publishing Group Ltd.Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCOVID-19Maternal medicinePaediatric infectious disease & immunisationPaediatric neurologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58409/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Martinez_Viviana_etal_INI_2023.pdfve_Martinez_Viviana_etal_INI_2023.pdfapplication/pdf781930https://www.arca.fiocruz.br/bitstream/icict/58409/2/ve_Martinez_Viviana_etal_INI_2023.pdf6590586e0075e6520f7cc11e982e7c61MD52icict/584092023-05-15 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dc.title.en_US.fl_str_mv Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study
title Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study
spellingShingle Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study
Martinez, Viviana Fajardo
COVID-19
Maternal medicine
Paediatric infectious disease & immunisation
Paediatric neurology
title_short Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study
title_full Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study
title_fullStr Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study
title_full_unstemmed Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study
title_sort Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study
author Martinez, Viviana Fajardo
author_facet Martinez, Viviana Fajardo
Zhang, Dajie
Paiola, Sophia
Mok, Thalia
Cambou, Mary C.
Kerin, Tara
Rao, Rashmi
Brasil, Patricia
Ferreira, Fatima
Fuller, Trevon
Bhattacharya, Debika
Foo, Suan-Sin
Chen, Weiqiang
Jung, Jae
Einspieler, Christa
Marschik, Peter B.
Nielsen-Saines, Karin
author_role author
author2 Zhang, Dajie
Paiola, Sophia
Mok, Thalia
Cambou, Mary C.
Kerin, Tara
Rao, Rashmi
Brasil, Patricia
Ferreira, Fatima
Fuller, Trevon
Bhattacharya, Debika
Foo, Suan-Sin
Chen, Weiqiang
Jung, Jae
Einspieler, Christa
Marschik, Peter B.
Nielsen-Saines, Karin
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Martinez, Viviana Fajardo
Zhang, Dajie
Paiola, Sophia
Mok, Thalia
Cambou, Mary C.
Kerin, Tara
Rao, Rashmi
Brasil, Patricia
Ferreira, Fatima
Fuller, Trevon
Bhattacharya, Debika
Foo, Suan-Sin
Chen, Weiqiang
Jung, Jae
Einspieler, Christa
Marschik, Peter B.
Nielsen-Saines, Karin
dc.subject.en.en_US.fl_str_mv COVID-19
Maternal medicine
Paediatric infectious disease & immunisation
Paediatric neurology
topic COVID-19
Maternal medicine
Paediatric infectious disease & immunisation
Paediatric neurology
description Ethics approval The study was approved by Institutional review boards at UCLA (IRB protocol 20-000569) and Fundação Oswaldo Cruz (Fiocruz/National Ethics Committee CONEP 30639420.0.0000.5262) with informed consent obtained from parents.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-15T23:27:35Z
dc.date.available.fl_str_mv 2023-05-15T23:27:35Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTINEZ, Viviana Fajardo et al. Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study. BMJ Open, v. 13, n. 1, p. 1-9, Jan. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58409
dc.identifier.issn.en_US.fl_str_mv 2044-6055
dc.identifier.doi.none.fl_str_mv 10.1136/bmjopen-2022-069194
dc.identifier.eissn.none.fl_str_mv 2044-6055
identifier_str_mv MARTINEZ, Viviana Fajardo et al. Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study. BMJ Open, v. 13, n. 1, p. 1-9, Jan. 2023.
2044-6055
10.1136/bmjopen-2022-069194
url https://www.arca.fiocruz.br/handle/icict/58409
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ Publishing Group Ltd.
publisher.none.fl_str_mv BMJ Publishing Group Ltd.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58409/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58409/2/ve_Martinez_Viviana_etal_INI_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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