Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31356 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. |
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Scalioni, Letícia de PaulaSantos, Betânia Rodrigues dosSpritzer, Poli MaraVillela-Nogueira, Cristiane AlvesLewis-Ximenez, Lia LauraPolo-Flores, PriscilaEsberard, Eliane Bordalo CathaláBrandão-Mello, Carlos EduardoLampe, ElisabethVillar, Livia Melo2019-01-30T11:25:34Z2019-01-30T11:25:34Z2018SCALIONI, Letícia de Paula et al. Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients: cross-sectional study. Medicine, v. 97, n. 8, p. 1-7, 2018.1357-3039https://www.arca.fiocruz.br/handle/icict/3135610.1097/MD.0000000000009881engWenyu LinFibroseHepatite CPolimorfismoVitamina DFibrosisHepatitis CPolymorphismVitamin DImpact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio Grande do Sul. Departamento de Fisiologia. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. Divisão de Endocrinologia. Unidade de Endocrinologia GInecológica. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Departamento de Fisiologia. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. Divisão de Endocrinologia. Unidade de Endocrinologia GInecológica. Porto Alegre, RS, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Clínica Médica. Unidade de Hepatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Hospital Universitário Antonio Pedro. Niterói, RJ, Brasil.Universidade Federal Fluminense. Hospital Universitário Antonio Pedro. Niterói, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Potential relationship of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (DBP) have been suggested in the pathophysiology of hepatitis C virus (HCV) infection. The aim of this observational study is to determine vitamin D levels, and VDR and DBP genetic polymorphism according demographic and laboratory data in chronic HCV patients (CHC). A total of 148 CHC patients gave serum samples for testing 25-hydroxyvitamin D (25 (OH)D) level by immunochemiluminometric assay (<20ng/mL defined as deficient) and donated blood samples to allelic discrimination analysis using TaqMan assays. Analyzed single nucleotide polymorphisms (SNPs) were: VDR-rs7975232 (ApaI) C>A, rs731236 A>G (TaqI), rs1544410 C>T (BsmI), rs10735810 T>C (FokI) and carrier globulin/binding protein (GC)-rs4588 and rs7041 and the haplotype bAt [CCA]. Hepatic fibrosis was assessed using Fib-4 and Forns index. Eighty-two (54.40%) patients demonstrated deficiency of vitamin D and this was associated to AST (P=.019 [CI: 1.003–1.034]), total cholesterol (P=.038 [CI: 1.004–1.164]), fibrosis grade (P<.001 [CI: 0.000–0.844]), and FokI (P=.028) allele T presence. Association was found between VDR polymorphism and fibrosis (BsmI andTaqI), triglycerides (TaqI), and HDL (FokI). DBP polymorphism was associated to HCV genotype (GC rs7041), previous HCV treatment, and GGT (GC rs4588). In conclusion, lowfrequency of vitamin D deficiencywas found, but VDR polymorphisms were frequently associated to fibrosis grade suggesting that they could be used as disease evaluation markers to understand the mechanisms underlying the virus–host interaction.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31356/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALleticiapaula_scallioni_etal_IOC_2018.pdfleticiapaula_scallioni_etal_IOC_2018.pdfapplication/pdf353966https://www.arca.fiocruz.br/bitstream/icict/31356/2/leticiapaula_scallioni_etal_IOC_2018.pdf1ba80e145962cec1c77daccdede2a623MD52TEXTleticiapaula_scallioni_etal_IOC_2018.pdf.txtleticiapaula_scallioni_etal_IOC_2018.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients |
| title |
Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients |
| spellingShingle |
Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients Scalioni, Letícia de Paula Fibrose Hepatite C Polimorfismo Vitamina D Fibrosis Hepatitis C Polymorphism Vitamin D |
| title_short |
Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients |
| title_full |
Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients |
| title_fullStr |
Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients |
| title_full_unstemmed |
Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients |
| title_sort |
Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients |
| author |
Scalioni, Letícia de Paula |
| author_facet |
Scalioni, Letícia de Paula Santos, Betânia Rodrigues dos Spritzer, Poli Mara Villela-Nogueira, Cristiane Alves Lewis-Ximenez, Lia Laura Polo-Flores, Priscila Esberard, Eliane Bordalo Cathalá Brandão-Mello, Carlos Eduardo Lampe, Elisabeth Villar, Livia Melo |
| author_role |
author |
| author2 |
Santos, Betânia Rodrigues dos Spritzer, Poli Mara Villela-Nogueira, Cristiane Alves Lewis-Ximenez, Lia Laura Polo-Flores, Priscila Esberard, Eliane Bordalo Cathalá Brandão-Mello, Carlos Eduardo Lampe, Elisabeth Villar, Livia Melo |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Scalioni, Letícia de Paula Santos, Betânia Rodrigues dos Spritzer, Poli Mara Villela-Nogueira, Cristiane Alves Lewis-Ximenez, Lia Laura Polo-Flores, Priscila Esberard, Eliane Bordalo Cathalá Brandão-Mello, Carlos Eduardo Lampe, Elisabeth Villar, Livia Melo |
| dc.subject.other.pt_BR.fl_str_mv |
Fibrose Hepatite C Polimorfismo Vitamina D |
| topic |
Fibrose Hepatite C Polimorfismo Vitamina D Fibrosis Hepatitis C Polymorphism Vitamin D |
| dc.subject.en.pt_BR.fl_str_mv |
Fibrosis Hepatitis C Polymorphism Vitamin D |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018 |
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2019-01-30T11:25:34Z |
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2019-01-30T11:25:34Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
SCALIONI, Letícia de Paula et al. Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients: cross-sectional study. Medicine, v. 97, n. 8, p. 1-7, 2018. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31356 |
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1357-3039 |
| dc.identifier.doi.none.fl_str_mv |
10.1097/MD.0000000000009881 |
| identifier_str_mv |
SCALIONI, Letícia de Paula et al. Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients: cross-sectional study. Medicine, v. 97, n. 8, p. 1-7, 2018. 1357-3039 10.1097/MD.0000000000009881 |
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https://www.arca.fiocruz.br/handle/icict/31356 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Wenyu Lin |
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Wenyu Lin |
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