Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24896 |
Resumo: | National Council for Scientific and Technological Development (CNPq) |
| id |
CRUZ_ec8a92b2f7ef5914c3e28722f312a828 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/24896 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Mendes, Ramon BarretoDias, Rosane BorgesFigueiredo, Andreia LealGurgel, Clarissa AraújoSantana Filho, ManoelMelo, Leonardo AraújoTrierveiler, MaríliaCury, Patrícia RamosLeonardi, RosaliaSantos, Jean Nunes DOS2018-02-20T18:22:43Z2018-02-20T18:22:43Z2017MENDES, R. B. et al. Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study. Journal of Oral Pathology and Medicine, v. 46, p. 297–300, 2017.0904-2512https://www.arca.fiocruz.br/handle/icict/2489610.1111/jop.12501National Council for Scientific and Technological Development (CNPq)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Department of Public Health. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, BrasilFederal University of Rio Grande do Sul. School of Dentistry. Department of Oral Pathology. Porto Alegre, RGS, BrazilFederal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Salvador, BA, BrazilUniversity of São Paulo. School of Dentistry. Department of Oral Pathology. São Paulo, SP, BrazilFederal University of Bahia. School of Dentistry. Department of Periodontics. Salvador, BA, BrazilUniversity of Catania. Department of Medical and Surgical Sciences. Catania, ItalyFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Salvador, BA, BrazilGlypican-3 is a cell surface proteoglycan that is found in embrionary tissues, and there are no studies investigating this protein in odontogenic tumor. Thus, the aim of this study was to investigate glypican-3 in a series of aggressive and non-aggressive odontogenic tumors. METHODS: Fifty-nine cases of tumors were divided into aggressive odontogenic tumors (20 solid ameloblastomas, four unicystic ameloblastoma, 28 KOTs including five associated with Gorlin–Goltz syndrome) and nonaggressive odontogenic tumors (five adenomatoid odontogenic tumors and two calcifying cystic odontogenic tumors) and analyzed for glypican-3 using immunohistochemistry. RESULTS: Glypican-3 was observed in seven solid ameloblastoma and eighteen keratocystic odontogenic tumors including three of the five syndromic cases, but there was no significant difference between syndromic and sporadic cases (P > 0.05; Fisher’s exact Test). All cases of unicystic ameloblastoma (n = 4), adenomatoid odontogenic tumor (n = 5), and calcifying cystic odontogenic tumor (n = 2) were negative. CONCLUSIONS: This provided insights into the presence of glypican-3 in odontogenic tumors. This protein distinguished aggressive from non-aggressive odontogenic tumors.engWileyAmeloblastomaGlypican-3Tumor odontogênico queratocísticoTtumores odontogênicosAmeloblastomaGlypican-3Keratocystic odontogenic tumorOdontogenic tumorsGlypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24896/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMendes RB Glypican-3 distinguishes aggressive....pdfMendes RB Glypican-3 distinguishes aggressive....pdfapplication/pdf445130https://www.arca.fiocruz.br/bitstream/icict/24896/2/Mendes%20RB%20Glypican-3%20distinguishes%20aggressive....pdff3743d0cb49249a7734bd81a3accc933MD52TEXTMendes RB Glypican-3 distinguishes aggressive....pdf.txtMendes RB Glypican-3 distinguishes aggressive....pdf.txtExtracted texttext/plain20550https://www.arca.fiocruz.br/bitstream/icict/24896/3/Mendes%20RB%20Glypican-3%20distinguishes%20aggressive....pdf.txte82014ab3269bdeb3ec0048eae637df9MD53icict/248962023-03-15 14:33:08.95oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:08Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study |
| title |
Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study |
| spellingShingle |
Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study Mendes, Ramon Barreto Ameloblastoma Glypican-3 Tumor odontogênico queratocístico Ttumores odontogênicos Ameloblastoma Glypican-3 Keratocystic odontogenic tumor Odontogenic tumors |
| title_short |
Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study |
| title_full |
Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study |
| title_fullStr |
Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study |
| title_full_unstemmed |
Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study |
| title_sort |
Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study |
| author |
Mendes, Ramon Barreto |
| author_facet |
Mendes, Ramon Barreto Dias, Rosane Borges Figueiredo, Andreia Leal Gurgel, Clarissa Araújo Santana Filho, Manoel Melo, Leonardo Araújo Trierveiler, Marília Cury, Patrícia Ramos Leonardi, Rosalia Santos, Jean Nunes DOS |
| author_role |
author |
| author2 |
Dias, Rosane Borges Figueiredo, Andreia Leal Gurgel, Clarissa Araújo Santana Filho, Manoel Melo, Leonardo Araújo Trierveiler, Marília Cury, Patrícia Ramos Leonardi, Rosalia Santos, Jean Nunes DOS |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mendes, Ramon Barreto Dias, Rosane Borges Figueiredo, Andreia Leal Gurgel, Clarissa Araújo Santana Filho, Manoel Melo, Leonardo Araújo Trierveiler, Marília Cury, Patrícia Ramos Leonardi, Rosalia Santos, Jean Nunes DOS |
| dc.subject.other.pt_BR.fl_str_mv |
Ameloblastoma Glypican-3 Tumor odontogênico queratocístico Ttumores odontogênicos |
| topic |
Ameloblastoma Glypican-3 Tumor odontogênico queratocístico Ttumores odontogênicos Ameloblastoma Glypican-3 Keratocystic odontogenic tumor Odontogenic tumors |
| dc.subject.en.pt_BR.fl_str_mv |
Ameloblastoma Glypican-3 Keratocystic odontogenic tumor Odontogenic tumors |
| description |
National Council for Scientific and Technological Development (CNPq) |
| publishDate |
2017 |
| dc.date.issued.fl_str_mv |
2017 |
| dc.date.accessioned.fl_str_mv |
2018-02-20T18:22:43Z |
| dc.date.available.fl_str_mv |
2018-02-20T18:22:43Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
MENDES, R. B. et al. Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study. Journal of Oral Pathology and Medicine, v. 46, p. 297–300, 2017. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/24896 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0904-2512 |
| dc.identifier.doi.none.fl_str_mv |
10.1111/jop.12501 |
| identifier_str_mv |
MENDES, R. B. et al. Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study. Journal of Oral Pathology and Medicine, v. 46, p. 297–300, 2017. 0904-2512 10.1111/jop.12501 |
| url |
https://www.arca.fiocruz.br/handle/icict/24896 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/24896/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/24896/2/Mendes%20RB%20Glypican-3%20distinguishes%20aggressive....pdf https://www.arca.fiocruz.br/bitstream/icict/24896/3/Mendes%20RB%20Glypican-3%20distinguishes%20aggressive....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 f3743d0cb49249a7734bd81a3accc933 e82014ab3269bdeb3ec0048eae637df9 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009087490686976 |