Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42494 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands. |
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Maya-Monteiro, Clarissa M.Silva, Felipe Corrêa daHofmann, Sussana S.Hesselink, Matthijs K. C.la Fleur, Sussanne E.Yi, Chun-Xia2020-07-31T19:24:02Z2020-07-31T19:24:02Z2020MAYA-MONTEIRO, Clarissa M. et al. Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases. Neuro-endocrinology, p. 1-41, May 2020.0028-3835https://www.arca.fiocruz.br/handle/icict/4249410.1159/0005087351423-0194engKarger PublishersCérebroGotícula lipídicaHipotálamoResistência à insulinaTipo 2 Diabestes MellitusBrainLipid dropletHypothalamusInsulin resistancePLIN2Type 2 Diabestes MellitusLipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands.Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.Department of Nutrition and Movement Sciences. Maastricht University Medical Centre+ and NUTRIM School for Nutrition and Translational Research in Metabolism. Maastricht, the NetherlandsLaboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands.In peripheral tissues, the lipid droplet (LD) organelle links lipid metabolism, inflammation and insulin resistance. Little is known about the brain LDs. Objectives: We hypothesised that hypothalamic LDs would be altered in metabolic diseases. Methods: We used immunofluorescence for the specific LD protein, PLIN2, as the marker to visualize and quantify LDs.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42494/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClarissaM_Monteiro_etal_IOC_2020.pdfClarissaM_Monteiro_etal_IOC_2020.pdfapplication/pdf7291654https://www.arca.fiocruz.br/bitstream/icict/42494/2/ClarissaM_Monteiro_etal_IOC_2020.pdf3d905d8605fbc35c9f5de0b2574226a0MD52TEXTClarissaM_Monteiro_etal_IOC_2020.pdf.txtClarissaM_Monteiro_etal_IOC_2020.pdf.txtExtracted texttext/plain85680https://www.arca.fiocruz.br/bitstream/icict/42494/3/ClarissaM_Monteiro_etal_IOC_2020.pdf.txt2cb4dbd51b2c5361269c007620dda198MD53icict/424942020-09-06 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| dc.title.pt_BR.fl_str_mv |
Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases |
| title |
Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases |
| spellingShingle |
Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases Maya-Monteiro, Clarissa M. Cérebro Gotícula lipídica Hipotálamo Resistência à insulina Tipo 2 Diabestes Mellitus Brain Lipid droplet Hypothalamus Insulin resistance PLIN2 Type 2 Diabestes Mellitus |
| title_short |
Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases |
| title_full |
Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases |
| title_fullStr |
Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases |
| title_full_unstemmed |
Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases |
| title_sort |
Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases |
| author |
Maya-Monteiro, Clarissa M. |
| author_facet |
Maya-Monteiro, Clarissa M. Silva, Felipe Corrêa da Hofmann, Sussana S. Hesselink, Matthijs K. C. la Fleur, Sussanne E. Yi, Chun-Xia |
| author_role |
author |
| author2 |
Silva, Felipe Corrêa da Hofmann, Sussana S. Hesselink, Matthijs K. C. la Fleur, Sussanne E. Yi, Chun-Xia |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Maya-Monteiro, Clarissa M. Silva, Felipe Corrêa da Hofmann, Sussana S. Hesselink, Matthijs K. C. la Fleur, Sussanne E. Yi, Chun-Xia |
| dc.subject.other.pt_BR.fl_str_mv |
Cérebro Gotícula lipídica Hipotálamo Resistência à insulina Tipo 2 Diabestes Mellitus |
| topic |
Cérebro Gotícula lipídica Hipotálamo Resistência à insulina Tipo 2 Diabestes Mellitus Brain Lipid droplet Hypothalamus Insulin resistance PLIN2 Type 2 Diabestes Mellitus |
| dc.subject.en.pt_BR.fl_str_mv |
Brain Lipid droplet Hypothalamus Insulin resistance PLIN2 Type 2 Diabestes Mellitus |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands. |
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2020 |
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2020-07-31T19:24:02Z |
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2020-07-31T19:24:02Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
MAYA-MONTEIRO, Clarissa M. et al. Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases. Neuro-endocrinology, p. 1-41, May 2020. |
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https://www.arca.fiocruz.br/handle/icict/42494 |
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0028-3835 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1159/000508735 |
| dc.identifier.eissn.none.fl_str_mv |
1423-0194 |
| identifier_str_mv |
MAYA-MONTEIRO, Clarissa M. et al. Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases. Neuro-endocrinology, p. 1-41, May 2020. 0028-3835 10.1159/000508735 1423-0194 |
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Karger Publishers |
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Karger Publishers |
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