Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology

Detalhes bibliográficos
Autor(a) principal: Lemaire, Denise Carneiro
Data de Publicação: 2012
Outros Autores: Bessa, Theolis Costa Barbosa, Rihet, P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6043
Resumo: Universidade Federal da Bahia. Salvador, BA, Brasil
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spelling Lemaire, Denise CarneiroBessa, Theolis Costa BarbosaRihet, P.2012-12-20T16:06:09Z2012-12-20T16:06:09Z2012LEMAIRE, D.; BARBOSA, T.; RIHET, P. Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology. Brazilian Journal of Medical and Biological Research, v. 45, n. 5, p. 376-385, may. 2012.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/6043engCoping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversité Aix-Marseille. Marseille, FranceVaccine development faces major difficulties partly because of genetic variation in both infectious organisms and humans. This causes antigenic variation in infectious agents and a high interindividual variability in the human response to the vaccine. The exponential growth of genome sequence information has induced a shift from conventional culture-based to genome-based vaccinology, and allows the tackling of challenges in vaccine development due to pathogen genetic variability. Additionally, recent advances in immunogenetics and genomics should help in the understanding of the influence of genetic factors on the interindividual and interpopulation variations in immune responses to vaccines, and could be useful for developing new vaccine strategies. Accumulating results provide evidence for the existence of a number of genes involved in protective immune responses that are induced either by natural infections or vaccines. Variation in immune responses could be viewed as the result of a perturbation of gene networks; this should help in understanding how a particular polymorphism or a combination thereof could affect protective immune responses. Here we will present: i) the first genome-based vaccines that served as proof of concept, and that provided new critical insights into vaccine development strategies; ii) an overview of genetic predisposition in infectious diseases and genetic control in responses to vaccines; iii) population genetic differences that are a rationale behind group-targeted vaccines; iv) an outlook for genetic control in infectious diseases, with special emphasis on the concept of molecular networks that will provide a structure to the huge amount of genomic data.Human vaccinesVaccinomicsGenetic variationImmunizationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLemaire, D et al. Coping with genetic.pdfLemaire, D et al. 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dc.title.pt_BR.fl_str_mv Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
title Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
spellingShingle Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
Lemaire, Denise Carneiro
Human vaccines
Vaccinomics
Genetic variation
Immunization
title_short Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
title_full Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
title_fullStr Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
title_full_unstemmed Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
title_sort Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
author Lemaire, Denise Carneiro
author_facet Lemaire, Denise Carneiro
Bessa, Theolis Costa Barbosa
Rihet, P.
author_role author
author2 Bessa, Theolis Costa Barbosa
Rihet, P.
author2_role author
author
dc.contributor.author.fl_str_mv Lemaire, Denise Carneiro
Bessa, Theolis Costa Barbosa
Rihet, P.
dc.subject.en.pt_BR.fl_str_mv Human vaccines
Vaccinomics
Genetic variation
Immunization
topic Human vaccines
Vaccinomics
Genetic variation
Immunization
description Universidade Federal da Bahia. Salvador, BA, Brasil
publishDate 2012
dc.date.accessioned.fl_str_mv 2012-12-20T16:06:09Z
dc.date.available.fl_str_mv 2012-12-20T16:06:09Z
dc.date.issued.fl_str_mv 2012
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEMAIRE, D.; BARBOSA, T.; RIHET, P. Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology. Brazilian Journal of Medical and Biological Research, v. 45, n. 5, p. 376-385, may. 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6043
dc.identifier.issn.none.fl_str_mv 0100-879X
identifier_str_mv LEMAIRE, D.; BARBOSA, T.; RIHET, P. Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology. Brazilian Journal of Medical and Biological Research, v. 45, n. 5, p. 376-385, may. 2012.
0100-879X
url https://www.arca.fiocruz.br/handle/icict/6043
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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