Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen

Detalhes bibliográficos
Autor(a) principal: Santos, Luara Isabela Dos
Data de Publicação: 2021
Outros Autores: Torres, Thais Abdala, Diniz, Suelen Queiroz, Gonçalves, Ricardo, Caballero-Flores, Gustavo, Núñez, Gabriel, Gazzinelli, Ricardo Tostes, Maloy, Kevin Joseph, Antonelli, Lis Ribeiro do Valle
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51186
Resumo: Instituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/ Sir William Dunn School of Pathology. University of Oxford. Oxford, OX1, UK.
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spelling Santos, Luara Isabela DosTorres, Thais AbdalaDiniz, Suelen QueirozGonçalves, RicardoCaballero-Flores, GustavoNúñez, GabrielGazzinelli, Ricardo TostesMaloy, Kevin JosephAntonelli, Lis Ribeiro do Valle2022-02-14T18:10:09Z2022-02-14T18:10:09Z2021SANTOS, Luara Isabela dos et al. Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular. Pathogen Cell Rep., v. 34, n. 2, 108613, 2021. doi: 10.1016/j.celrep.2020.108613.2211-1247https://www.arca.fiocruz.br/handle/icict/51186engCell PressDisrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/ Sir William Dunn School of Pathology. University of Oxford. Oxford, OX1, UK.Instituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.Instituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.Departamento de Patologia Geral. ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minhas Gerais, Brazil.Department of Pathology and Rogel Cancer Center. University of Michigan Medical School. Ann Arbor, MI, USA.Department of Pathology and Rogel Cancer Center. University of Michigan Medical School. Ann Arbor, MI, USA.Instituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/ Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Worcester, MA, USA.Sir William Dunn School of Pathology. University of Oxford. Oxford, OX1, UK/Institute of Infection, Immunity and Inflammation. University of Glasgow. Glasgow, Scotland.Instituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil.Individuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr-) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an extracellular Gr- bacterial pathogen that infects the large intestine. While single infections are controlled effectively, co-infection results in enhanced virulence that is characterized by prolonged systemic bacterial persistence and high mortality. Mortality in co-infected mice is associated with disrupted iron metabolism, elevated levels of plasma heme, and increased mitochondrial reactive oxygen species (ROS) production by phagocytes. In addition, iron acquisition by the bacterium plays a key role in pathogenesis because co-infection with a mutant C. rodentium strain lacking a critical iron acquisition pathway does not cause mortality. These results indicate that disrupted iron metabolism may drive mortality during co-infection with C. rodentium and P. chabaudi by both altering host immune responses and facilitating bacterial persistenceCitrobacter rodentiumGram-negative bacteriaPlasmodiumco-infectionhemehemolysisironmalariamortalityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51186/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALDisrupted Iron Metabolism and Mortality during.pdfDisrupted Iron Metabolism and Mortality during.pdfapplication/pdf5480545https://www.arca.fiocruz.br/bitstream/icict/51186/2/Disrupted%20Iron%20Metabolism%20and%20Mortality%20during.pdfb8a3780a150fc5cd36f69307adfbb9b3MD52icict/511862023-08-09 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dc.title.pt_BR.fl_str_mv Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
title Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
spellingShingle Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
Santos, Luara Isabela Dos
Citrobacter rodentium
Gram-negative bacteria
Plasmodium
co-infection
heme
hemolysis
iron
malaria
mortality
title_short Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
title_full Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
title_fullStr Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
title_full_unstemmed Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
title_sort Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
author Santos, Luara Isabela Dos
author_facet Santos, Luara Isabela Dos
Torres, Thais Abdala
Diniz, Suelen Queiroz
Gonçalves, Ricardo
Caballero-Flores, Gustavo
Núñez, Gabriel
Gazzinelli, Ricardo Tostes
Maloy, Kevin Joseph
Antonelli, Lis Ribeiro do Valle
author_role author
author2 Torres, Thais Abdala
Diniz, Suelen Queiroz
Gonçalves, Ricardo
Caballero-Flores, Gustavo
Núñez, Gabriel
Gazzinelli, Ricardo Tostes
Maloy, Kevin Joseph
Antonelli, Lis Ribeiro do Valle
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Luara Isabela Dos
Torres, Thais Abdala
Diniz, Suelen Queiroz
Gonçalves, Ricardo
Caballero-Flores, Gustavo
Núñez, Gabriel
Gazzinelli, Ricardo Tostes
Maloy, Kevin Joseph
Antonelli, Lis Ribeiro do Valle
dc.subject.en.pt_BR.fl_str_mv Citrobacter rodentium
Gram-negative bacteria
Plasmodium
co-infection
heme
hemolysis
iron
malaria
mortality
topic Citrobacter rodentium
Gram-negative bacteria
Plasmodium
co-infection
heme
hemolysis
iron
malaria
mortality
description Instituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/ Sir William Dunn School of Pathology. University of Oxford. Oxford, OX1, UK.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-14T18:10:09Z
dc.date.available.fl_str_mv 2022-02-14T18:10:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Luara Isabela dos et al. Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular. Pathogen Cell Rep., v. 34, n. 2, 108613, 2021. doi: 10.1016/j.celrep.2020.108613.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51186
dc.identifier.issn.pt_BR.fl_str_mv 2211-1247
identifier_str_mv SANTOS, Luara Isabela dos et al. Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular. Pathogen Cell Rep., v. 34, n. 2, 108613, 2021. doi: 10.1016/j.celrep.2020.108613.
2211-1247
url https://www.arca.fiocruz.br/handle/icict/51186
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51186/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51186/2/Disrupted%20Iron%20Metabolism%20and%20Mortality%20during.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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