Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans

Detalhes bibliográficos
Autor(a) principal: Guidoti, Daniela Granella Gomes
Data de Publicação: 2019
Outros Autores: Guidoti, David Teixeira, Romero, Adriano Lopes, Ruiz, Ana Lúcia Tasca Gois, Foglio, Mary Ann, Carvalho, João Ernesto de, Rocha, Carmem Lúcia de Mello Sartori Cardoso da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39971
Resumo: Universidade Estadual de Maringá. Secretaria de Biologia Comparada. Laboratório de Genética Molecular e do Desenvolvimento. Maringá, PR, Brasil.
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spelling Guidoti, Daniela Granella GomesGuidoti, David TeixeiraRomero, Adriano LopesRuiz, Ana Lúcia Tasca GoisFoglio, Mary AnnCarvalho, João Ernesto deRocha, Carmem Lúcia de Mello Sartori Cardoso da2020-02-17T11:40:57Z2020-02-17T11:40:57Z2019GUIDOTI, Daniela Granella Gomes et al. Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans. Revista Fitos, Rio de Janeiro, v. 13, n. 2, p. 122-136, 2019.1808-9569https://www.arca.fiocruz.br/handle/icict/3997110.17648/2446-4775.2019.7162446-4775Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde.Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulansinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Maringá. Secretaria de Biologia Comparada. Laboratório de Genética Molecular e do Desenvolvimento. Maringá, PR, Brasil.Universidade Estadual de Maringá. Secretaria de Biologia Comparada. Laboratório de Genética Molecular e do Desenvolvimento. Maringá, PR, Brasil.Universidade Tecnológica Federal do Paraná. Campo Mourão, PR, Brasil.Universidade Estadual de Campinas. Faculdade de Ciências Farmacêuticas. Campinas, SP, Brasil.Universidade Estadual de Campinas. Faculdade de Ciências Farmacêuticas. Campinas, SP, Brasil.Universidade Estadual de Campinas. Faculdade de Ciências Farmacêuticas. Campinas, SP, Brasil.Universidade Estadual de Maringá. Centro de Ciências Biológicas. Departamento de Biologia Celular e Genética. Maringá, PR, Brasil.Annona squamosa is a source of bioactive compounds, with several pharmacological activities. However, tests are needed to confirm the safety of these compounds in terms of cytogenotoxic potential and their possible medicinal activity. Thus, the aims of the present study were to isolate kaurenoic acid from sugar apple peel and determine its antiproliferative activity in nine human tumor cell lines and mutagenic activity in germinating Aspergillus nidulans conidia. Chemical extraction resulted in the isolation of kaurenoic acid, a terpene that demonstrated a cytostatic effect at concentrations of 25 and 250 µg mL-1 and antiproliferative at a concentration 250 µg mL-1. The germination test showed that this compound can activate apoptosis, since there was an increase in dead conidia and a decrease in malformed individuals in all treatments. These results indicate its antiproliferative effect and apoptosis activation, representing a useful tool in the development of new chemotherapy drugs.DiterpeneCytostatic ActivityCytocidal EffectSugar Appleinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/39971/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALdaniela_granella_gomes_et_all.pdfapplication/pdf726691https://www.arca.fiocruz.br/bitstream/icict/39971/2/daniela_granella_gomes_et_all.pdfe6e3f7c19e3b105914c0d5f2ed57ec31MD52TEXTdaniela_granella_gomes_et_all.pdf.txtdaniela_granella_gomes_et_all.pdf.txtExtracted texttext/plain44260https://www.arca.fiocruz.br/bitstream/icict/39971/3/daniela_granella_gomes_et_all.pdf.txt7a2466e2990beab5f6ebb03862d14d4aMD53icict/399712020-03-25 23:00:43.176oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-03-26T02:00:43Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans
title Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans
spellingShingle Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans
Guidoti, Daniela Granella Gomes
Diterpene
Cytostatic Activity
Cytocidal Effect
Sugar Apple
title_short Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans
title_full Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans
title_fullStr Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans
title_full_unstemmed Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans
title_sort Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans
author Guidoti, Daniela Granella Gomes
author_facet Guidoti, Daniela Granella Gomes
Guidoti, David Teixeira
Romero, Adriano Lopes
Ruiz, Ana Lúcia Tasca Gois
Foglio, Mary Ann
Carvalho, João Ernesto de
Rocha, Carmem Lúcia de Mello Sartori Cardoso da
author_role author
author2 Guidoti, David Teixeira
Romero, Adriano Lopes
Ruiz, Ana Lúcia Tasca Gois
Foglio, Mary Ann
Carvalho, João Ernesto de
Rocha, Carmem Lúcia de Mello Sartori Cardoso da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Guidoti, Daniela Granella Gomes
Guidoti, David Teixeira
Romero, Adriano Lopes
Ruiz, Ana Lúcia Tasca Gois
Foglio, Mary Ann
Carvalho, João Ernesto de
Rocha, Carmem Lúcia de Mello Sartori Cardoso da
dc.subject.en.pt_BR.fl_str_mv Diterpene
Cytostatic Activity
Cytocidal Effect
Sugar Apple
topic Diterpene
Cytostatic Activity
Cytocidal Effect
Sugar Apple
description Universidade Estadual de Maringá. Secretaria de Biologia Comparada. Laboratório de Genética Molecular e do Desenvolvimento. Maringá, PR, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-02-17T11:40:57Z
dc.date.available.fl_str_mv 2020-02-17T11:40:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv GUIDOTI, Daniela Granella Gomes et al. Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans. Revista Fitos, Rio de Janeiro, v. 13, n. 2, p. 122-136, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39971
dc.identifier.issn.pt_BR.fl_str_mv 1808-9569
dc.identifier.doi.pt_BR.fl_str_mv 10.17648/2446-4775.2019.716
dc.identifier.eissn.none.fl_str_mv 2446-4775
identifier_str_mv GUIDOTI, Daniela Granella Gomes et al. Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans. Revista Fitos, Rio de Janeiro, v. 13, n. 2, p. 122-136, 2019.
1808-9569
10.17648/2446-4775.2019.716
2446-4775
url https://www.arca.fiocruz.br/handle/icict/39971
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde.
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