The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells

Detalhes bibliográficos
Autor(a) principal: Oliveira, Diêgo Madureira de
Data de Publicação: 2016
Outros Autores: Lima, Rute Maria Ferreira, Clarencio, Jorge, Velozo, Eudes da Silva, Amorim, Ilza Alves de, Mota, Tales Henrique Andrade da, Costa, Silvia Lima, Silva, Fábio Pittella, El-Bachá, Ramon Dos Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16531
Resumo: CNPq
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spelling Oliveira, Diêgo Madureira deLima, Rute Maria FerreiraClarencio, JorgeVelozo, Eudes da SilvaAmorim, Ilza Alves deMota, Tales Henrique Andrade daCosta, Silvia LimaSilva, Fábio PittellaEl-Bachá, Ramon Dos Santos2016-12-14T19:14:36Z2016-12-14T19:14:36Z2016OLIVEIRA, D. M. et al. The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells. Neurochemistry International, v. 99, p. 33-41, 20160197-0186https://www.arca.fiocruz.br/handle/icict/1653110.1016/j.neuint.2016.06.004CNPqUniversity of Brasilia. Department of Biological Basis of Health Sciences. Brasília, DF, Brasil / University of Brasilia. Laboratory of Molecular Pathology of Cancer. Brasília, DF, BrasilFederal University of Bahia. Institute of Health Sciences. Laboratory of Neurochemistry and Cell Biology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / School of Medicine. Public Health of Bahia. Salvador, BA, BrasilFederal University of Bahia. Faculty of Pharmacy. LAPEMM. Salvador, BA, BrasilFederal University of Bahia. Faculty of Pharmacy. LAPEMM. Salvador, BA, BrasilUniversity of Brasilia. School of Pharmacy. Ceilândia, DF, BrasilFederal University of Bahia. Institute of Health Sciences. Laboratory of Neurochemistry and Cell Biology. Salvador, BA, BrasilUniversity of Brasilia. Laboratory of Molecular Pathology of Cancer. Brasília, DF, BrasilFederal University of Bahia. Institute of Health Sciences. Laboratory of Neurochemistry and Cell Biology. Salvador, BA, BrasilCurrently, there is no effective therapy for high grade gliomas. 8-Methoxypsoralen (8-MOP) is a compound used in the treatment of skin diseases combined with UV light irradiation. In this work, rat glioma C6 cells, normal astrocytes and human glioblastoma GL-15 cells comprised an in vitro model to evaluate the antitumor activity of 8-MOP. We found that 8-MOP promoted a time- and concentration-dependent reduction of cell viability in tumor, but not in normal cells. This effect was more evident in log-phase growing culture, indicating antiproliferative activity, which was confirmed by colony formation assay. Long-term effect of 8-MOP at low concentration was also attested. The concentrations used in the tests (0.02-0.4 mM) were lower than plasmatic concentration found in patients. Despite the treatment leads to considerable morphological changes and apoptosis when used at high concentrations, 8-MOP did not promote cell cycle arrest, change in migration pattern neither necrosis. In addition, we evaluated the effect of 8-MOP in MDA-MB-231, CT-26 and SCC-3 cell lines, derived from other kind of primary tumors, and found that CT-26 cells did not respond to 8-MOP treatment, indicating that this compound does not act through a generic mechanism. Coumarin derivatives structurally related to 8-MOP were screened for its antitumor potential and presented different patterns of biological activity, and then it was possible to suggest the relevance of 8-MOP molecular structure for antiproliferative action. Therefore, 8-MOP, a drug with an outstanding record of safety, and related coumarins are good prototypes for development of a new class of anti-glioma drugs.engElsevierGlioma8-metoxipsoralenoPsoralenoCoumarinasGlioma8-methoxypsoralenPsoralenCoumarinsThe classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16531/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOliveira DM The classical photoactivated....pdfOliveira DM The classical 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dc.title.pt_BR.fl_str_mv The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells
title The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells
spellingShingle The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells
Oliveira, Diêgo Madureira de
Glioma
8-metoxipsoraleno
Psoraleno
Coumarinas
Glioma
8-methoxypsoralen
Psoralen
Coumarins
title_short The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells
title_full The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells
title_fullStr The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells
title_full_unstemmed The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells
title_sort The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells
author Oliveira, Diêgo Madureira de
author_facet Oliveira, Diêgo Madureira de
Lima, Rute Maria Ferreira
Clarencio, Jorge
Velozo, Eudes da Silva
Amorim, Ilza Alves de
Mota, Tales Henrique Andrade da
Costa, Silvia Lima
Silva, Fábio Pittella
El-Bachá, Ramon Dos Santos
author_role author
author2 Lima, Rute Maria Ferreira
Clarencio, Jorge
Velozo, Eudes da Silva
Amorim, Ilza Alves de
Mota, Tales Henrique Andrade da
Costa, Silvia Lima
Silva, Fábio Pittella
El-Bachá, Ramon Dos Santos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Diêgo Madureira de
Lima, Rute Maria Ferreira
Clarencio, Jorge
Velozo, Eudes da Silva
Amorim, Ilza Alves de
Mota, Tales Henrique Andrade da
Costa, Silvia Lima
Silva, Fábio Pittella
El-Bachá, Ramon Dos Santos
dc.subject.other.pt_BR.fl_str_mv Glioma
8-metoxipsoraleno
Psoraleno
Coumarinas
topic Glioma
8-metoxipsoraleno
Psoraleno
Coumarinas
Glioma
8-methoxypsoralen
Psoralen
Coumarins
dc.subject.en.pt_BR.fl_str_mv Glioma
8-methoxypsoralen
Psoralen
Coumarins
description CNPq
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-14T19:14:36Z
dc.date.available.fl_str_mv 2016-12-14T19:14:36Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, D. M. et al. The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells. Neurochemistry International, v. 99, p. 33-41, 2016
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16531
dc.identifier.issn.pt_BR.fl_str_mv 0197-0186
dc.identifier.doi.none.fl_str_mv 10.1016/j.neuint.2016.06.004
identifier_str_mv OLIVEIRA, D. M. et al. The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells. Neurochemistry International, v. 99, p. 33-41, 2016
0197-0186
10.1016/j.neuint.2016.06.004
url https://www.arca.fiocruz.br/handle/icict/16531
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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