Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort

Detalhes bibliográficos
Autor(a) principal: Solcà, Manuela da Silva
Data de Publicação: 2021
Outros Autores: Arruda, Maiara Reis, Leite, Bruna Martins Macedo, Mota, Tiago Feitosa, Rebouças, Miriam Flores, Jesus, Matheus Silva de, Amorim, Leila Denise Alves Ferreira, Borges, Valéria Matos, Valenzuela, Jesus, Kamhawi, Shaden, Veras, Patrícia Sampaio Tavares, Fraga, Deborah Bittencourt Mothé, Brodskyn, Claudia Ida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46629
Resumo: Fundac¸ão de Amparo à Pesquisa do Estado da Bahia-FAPESB (N˚SUS0036/2013 and PET0024/ 2013 to C.I.B.); a grant from the Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico (402670/2012-4 to C.I.B. and 400898/2013-6 to P. S.T.V.); grants from the Instituto Nacional de Ciência e Tecnologia em Doenc¸as Tropicais (INCTDT) (to D. B. M. F. and P. S. T. V.), from the Intramural Research Programs at the NIAID, NIH, USA (S.K., J.V.) and the Instituto Nacional de Ciência e Tecnologia de Investigac¸ão em Imunologia (III-INCT) (to C. I. B.). PrInt Fiocruz- Capes (grant n˚01/2021) to C.I.B. and D.B.M.F. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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spelling Solcà, Manuela da SilvaArruda, Maiara ReisLeite, Bruna Martins MacedoMota, Tiago FeitosaRebouças, Miriam FloresJesus, Matheus Silva deAmorim, Leila Denise Alves FerreiraBorges, Valéria MatosValenzuela, JesusKamhawi, ShadenVeras, Patrícia Sampaio TavaresFraga, Deborah Bittencourt MothéBrodskyn, Claudia Ida2021-04-12T11:44:03Z2021-04-12T11:44:03Z2021SOLCA, Manuela da Silva et al. Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort. PLOS Neglected Tropical Diseases, fev. 2021.1935-2735https://www.arca.fiocruz.br/handle/icict/4662910.1371/journal.pntd.0009137Fundac¸ão de Amparo à Pesquisa do Estado da Bahia-FAPESB (N˚SUS0036/2013 and PET0024/ 2013 to C.I.B.); a grant from the Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico (402670/2012-4 to C.I.B. and 400898/2013-6 to P. S.T.V.); grants from the Instituto Nacional de Ciência e Tecnologia em Doenc¸as Tropicais (INCTDT) (to D. B. M. F. and P. S. T. V.), from the Intramural Research Programs at the NIAID, NIH, USA (S.K., J.V.) and the Instituto Nacional de Ciência e Tecnologia de Investigac¸ão em Imunologia (III-INCT) (to C. I. B.). PrInt Fiocruz- Capes (grant n˚01/2021) to C.I.B. and D.B.M.F. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Universidade Federal da Bahia. Instituto de Matemática e Estatística. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research,Rockville. Maryland, United States of America.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil.Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Investigação em Imunologia. São Paulo, SP, Brasil.Reports have shown correlations between the immune response to vector saliva and Leishmaniasis outcome. We followed dogs in an endemic area for two years characterizing resistance or susceptibility to canine visceral leishmaniasis (CVL) according to Leishmania infantum diagnosis and clinical development criteria. Then, we aimed to identify a biosignature based on parasite load, serum biological mediators’ interactions, and vector exposure intensity associated with CVL resistance and susceptibility. Methodology/Principal findings A prospective two-year study was conducted in an area endemic for CVL. Dogs were evaluated at 6-month intervals to determine infection, clinical manifestations, immune profile, and sandfly exposure. CVL resistance or susceptibility was determined upon the conclusion of the study. After two years, 78% of the dogs were infected with L. infantum (53% susceptible and 47% resistant to CVL). Susceptible dogs presented higher splenic parasite load as well as persistence of the parasite during the follow-up, compared to resistant ones. Susceptible dogs also displayed a higher number of correlations among the investigated biological mediators, before and after infection diagnosis. At baseline, anti-saliva antibodies, indicative of exposure to the vector, were detected in 62% of the dogs, reaching 100% in one year. Higher sandfly exposure increased the risk of susceptibility to CVL by 1.6 times (CI: 1.11–2.41). We identified a discriminatory biosignature between the resistant and susceptible dogs assessing splenic parasite load, interaction of biological mediators, PGE2 serum levels and intensity of exposure to sandfly. All these parameters were elevated in susceptible dogs compared to resistant animals. Conclusions/Significance The biosignature identified in our study reinforces the idea that CVL is a complex multifactorial disease that is affected by a set of factors which are correlated and, for a better understanding of CVL, should not be evaluated in an isolated way.engPublic Library of ScienceLeishmaniaLeishmaniose visceralSalivaPsychodidaeCãesInfecçõesLeishmaniasisVisceral leishmaniasisSalivaPsychodidaeDogsInfectionImmune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohortinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46629/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSolca, Manuela da Silva Immune....pdfSolca, Manuela 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dc.title.pt_BR.fl_str_mv Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
title Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
spellingShingle Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
Solcà, Manuela da Silva
Leishmania
Leishmaniose visceral
Saliva
Psychodidae
Cães
Infecções
Leishmaniasis
Visceral leishmaniasis
Saliva
Psychodidae
Dogs
Infection
title_short Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
title_full Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
title_fullStr Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
title_full_unstemmed Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
title_sort Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
author Solcà, Manuela da Silva
author_facet Solcà, Manuela da Silva
Arruda, Maiara Reis
Leite, Bruna Martins Macedo
Mota, Tiago Feitosa
Rebouças, Miriam Flores
Jesus, Matheus Silva de
Amorim, Leila Denise Alves Ferreira
Borges, Valéria Matos
Valenzuela, Jesus
Kamhawi, Shaden
Veras, Patrícia Sampaio Tavares
Fraga, Deborah Bittencourt Mothé
Brodskyn, Claudia Ida
author_role author
author2 Arruda, Maiara Reis
Leite, Bruna Martins Macedo
Mota, Tiago Feitosa
Rebouças, Miriam Flores
Jesus, Matheus Silva de
Amorim, Leila Denise Alves Ferreira
Borges, Valéria Matos
Valenzuela, Jesus
Kamhawi, Shaden
Veras, Patrícia Sampaio Tavares
Fraga, Deborah Bittencourt Mothé
Brodskyn, Claudia Ida
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Solcà, Manuela da Silva
Arruda, Maiara Reis
Leite, Bruna Martins Macedo
Mota, Tiago Feitosa
Rebouças, Miriam Flores
Jesus, Matheus Silva de
Amorim, Leila Denise Alves Ferreira
Borges, Valéria Matos
Valenzuela, Jesus
Kamhawi, Shaden
Veras, Patrícia Sampaio Tavares
Fraga, Deborah Bittencourt Mothé
Brodskyn, Claudia Ida
dc.subject.other.pt_BR.fl_str_mv Leishmania
Leishmaniose visceral
Saliva
Psychodidae
Cães
Infecções
topic Leishmania
Leishmaniose visceral
Saliva
Psychodidae
Cães
Infecções
Leishmaniasis
Visceral leishmaniasis
Saliva
Psychodidae
Dogs
Infection
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Visceral leishmaniasis
Saliva
Psychodidae
Dogs
Infection
description Fundac¸ão de Amparo à Pesquisa do Estado da Bahia-FAPESB (N˚SUS0036/2013 and PET0024/ 2013 to C.I.B.); a grant from the Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico (402670/2012-4 to C.I.B. and 400898/2013-6 to P. S.T.V.); grants from the Instituto Nacional de Ciência e Tecnologia em Doenc¸as Tropicais (INCTDT) (to D. B. M. F. and P. S. T. V.), from the Intramural Research Programs at the NIAID, NIH, USA (S.K., J.V.) and the Instituto Nacional de Ciência e Tecnologia de Investigac¸ão em Imunologia (III-INCT) (to C. I. B.). PrInt Fiocruz- Capes (grant n˚01/2021) to C.I.B. and D.B.M.F. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-12T11:44:03Z
dc.date.available.fl_str_mv 2021-04-12T11:44:03Z
dc.date.issued.fl_str_mv 2021
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dc.identifier.citation.fl_str_mv SOLCA, Manuela da Silva et al. Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort. PLOS Neglected Tropical Diseases, fev. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46629
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0009137
identifier_str_mv SOLCA, Manuela da Silva et al. Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort. PLOS Neglected Tropical Diseases, fev. 2021.
1935-2735
10.1371/journal.pntd.0009137
url https://www.arca.fiocruz.br/handle/icict/46629
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dc.publisher.none.fl_str_mv Public Library of Science
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