Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46629 |
Resumo: | Fundac¸ão de Amparo à Pesquisa do Estado da Bahia-FAPESB (N˚SUS0036/2013 and PET0024/ 2013 to C.I.B.); a grant from the Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico (402670/2012-4 to C.I.B. and 400898/2013-6 to P. S.T.V.); grants from the Instituto Nacional de Ciência e Tecnologia em Doenc¸as Tropicais (INCTDT) (to D. B. M. F. and P. S. T. V.), from the Intramural Research Programs at the NIAID, NIH, USA (S.K., J.V.) and the Instituto Nacional de Ciência e Tecnologia de Investigac¸ão em Imunologia (III-INCT) (to C. I. B.). PrInt Fiocruz- Capes (grant n˚01/2021) to C.I.B. and D.B.M.F. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
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Solcà, Manuela da SilvaArruda, Maiara ReisLeite, Bruna Martins MacedoMota, Tiago FeitosaRebouças, Miriam FloresJesus, Matheus Silva deAmorim, Leila Denise Alves FerreiraBorges, Valéria MatosValenzuela, JesusKamhawi, ShadenVeras, Patrícia Sampaio TavaresFraga, Deborah Bittencourt MothéBrodskyn, Claudia Ida2021-04-12T11:44:03Z2021-04-12T11:44:03Z2021SOLCA, Manuela da Silva et al. Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort. PLOS Neglected Tropical Diseases, fev. 2021.1935-2735https://www.arca.fiocruz.br/handle/icict/4662910.1371/journal.pntd.0009137Fundac¸ão de Amparo à Pesquisa do Estado da Bahia-FAPESB (N˚SUS0036/2013 and PET0024/ 2013 to C.I.B.); a grant from the Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico (402670/2012-4 to C.I.B. and 400898/2013-6 to P. S.T.V.); grants from the Instituto Nacional de Ciência e Tecnologia em Doenc¸as Tropicais (INCTDT) (to D. B. M. F. and P. S. T. V.), from the Intramural Research Programs at the NIAID, NIH, USA (S.K., J.V.) and the Instituto Nacional de Ciência e Tecnologia de Investigac¸ão em Imunologia (III-INCT) (to C. I. B.). PrInt Fiocruz- Capes (grant n˚01/2021) to C.I.B. and D.B.M.F. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Universidade Federal da Bahia. Instituto de Matemática e Estatística. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research,Rockville. Maryland, United States of America.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil.Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Investigação em Imunologia. São Paulo, SP, Brasil.Reports have shown correlations between the immune response to vector saliva and Leishmaniasis outcome. We followed dogs in an endemic area for two years characterizing resistance or susceptibility to canine visceral leishmaniasis (CVL) according to Leishmania infantum diagnosis and clinical development criteria. Then, we aimed to identify a biosignature based on parasite load, serum biological mediators’ interactions, and vector exposure intensity associated with CVL resistance and susceptibility. Methodology/Principal findings A prospective two-year study was conducted in an area endemic for CVL. Dogs were evaluated at 6-month intervals to determine infection, clinical manifestations, immune profile, and sandfly exposure. CVL resistance or susceptibility was determined upon the conclusion of the study. After two years, 78% of the dogs were infected with L. infantum (53% susceptible and 47% resistant to CVL). Susceptible dogs presented higher splenic parasite load as well as persistence of the parasite during the follow-up, compared to resistant ones. Susceptible dogs also displayed a higher number of correlations among the investigated biological mediators, before and after infection diagnosis. At baseline, anti-saliva antibodies, indicative of exposure to the vector, were detected in 62% of the dogs, reaching 100% in one year. Higher sandfly exposure increased the risk of susceptibility to CVL by 1.6 times (CI: 1.11–2.41). We identified a discriminatory biosignature between the resistant and susceptible dogs assessing splenic parasite load, interaction of biological mediators, PGE2 serum levels and intensity of exposure to sandfly. All these parameters were elevated in susceptible dogs compared to resistant animals. Conclusions/Significance The biosignature identified in our study reinforces the idea that CVL is a complex multifactorial disease that is affected by a set of factors which are correlated and, for a better understanding of CVL, should not be evaluated in an isolated way.engPublic Library of ScienceLeishmaniaLeishmaniose visceralSalivaPsychodidaeCãesInfecçõesLeishmaniasisVisceral leishmaniasisSalivaPsychodidaeDogsInfectionImmune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohortinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46629/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSolca, Manuela da Silva Immune....pdfSolca, Manuela 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dc.title.pt_BR.fl_str_mv |
Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort |
title |
Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort |
spellingShingle |
Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort Solcà, Manuela da Silva Leishmania Leishmaniose visceral Saliva Psychodidae Cães Infecções Leishmaniasis Visceral leishmaniasis Saliva Psychodidae Dogs Infection |
title_short |
Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort |
title_full |
Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort |
title_fullStr |
Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort |
title_full_unstemmed |
Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort |
title_sort |
Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort |
author |
Solcà, Manuela da Silva |
author_facet |
Solcà, Manuela da Silva Arruda, Maiara Reis Leite, Bruna Martins Macedo Mota, Tiago Feitosa Rebouças, Miriam Flores Jesus, Matheus Silva de Amorim, Leila Denise Alves Ferreira Borges, Valéria Matos Valenzuela, Jesus Kamhawi, Shaden Veras, Patrícia Sampaio Tavares Fraga, Deborah Bittencourt Mothé Brodskyn, Claudia Ida |
author_role |
author |
author2 |
Arruda, Maiara Reis Leite, Bruna Martins Macedo Mota, Tiago Feitosa Rebouças, Miriam Flores Jesus, Matheus Silva de Amorim, Leila Denise Alves Ferreira Borges, Valéria Matos Valenzuela, Jesus Kamhawi, Shaden Veras, Patrícia Sampaio Tavares Fraga, Deborah Bittencourt Mothé Brodskyn, Claudia Ida |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Solcà, Manuela da Silva Arruda, Maiara Reis Leite, Bruna Martins Macedo Mota, Tiago Feitosa Rebouças, Miriam Flores Jesus, Matheus Silva de Amorim, Leila Denise Alves Ferreira Borges, Valéria Matos Valenzuela, Jesus Kamhawi, Shaden Veras, Patrícia Sampaio Tavares Fraga, Deborah Bittencourt Mothé Brodskyn, Claudia Ida |
dc.subject.other.pt_BR.fl_str_mv |
Leishmania Leishmaniose visceral Saliva Psychodidae Cães Infecções |
topic |
Leishmania Leishmaniose visceral Saliva Psychodidae Cães Infecções Leishmaniasis Visceral leishmaniasis Saliva Psychodidae Dogs Infection |
dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis Visceral leishmaniasis Saliva Psychodidae Dogs Infection |
description |
Fundac¸ão de Amparo à Pesquisa do Estado da Bahia-FAPESB (N˚SUS0036/2013 and PET0024/ 2013 to C.I.B.); a grant from the Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico (402670/2012-4 to C.I.B. and 400898/2013-6 to P. S.T.V.); grants from the Instituto Nacional de Ciência e Tecnologia em Doenc¸as Tropicais (INCTDT) (to D. B. M. F. and P. S. T. V.), from the Intramural Research Programs at the NIAID, NIH, USA (S.K., J.V.) and the Instituto Nacional de Ciência e Tecnologia de Investigac¸ão em Imunologia (III-INCT) (to C. I. B.). PrInt Fiocruz- Capes (grant n˚01/2021) to C.I.B. and D.B.M.F. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-04-12T11:44:03Z |
dc.date.available.fl_str_mv |
2021-04-12T11:44:03Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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dc.identifier.citation.fl_str_mv |
SOLCA, Manuela da Silva et al. Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort. PLOS Neglected Tropical Diseases, fev. 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/46629 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2735 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0009137 |
identifier_str_mv |
SOLCA, Manuela da Silva et al. Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort. PLOS Neglected Tropical Diseases, fev. 2021. 1935-2735 10.1371/journal.pntd.0009137 |
url |
https://www.arca.fiocruz.br/handle/icict/46629 |
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eng |
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Public Library of Science |
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Public Library of Science |
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