Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Remy Martins
Data de Publicação: 2023
Outros Autores: Hottz, Eugenio D., Bozza, Patricia T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58984
Resumo: Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Programa de Imunologia e Inflamação. Rio de Janeiro, RJ, Brasil.
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spelling Gonçalves, Remy MartinsHottz, Eugenio D.Bozza, Patricia T.2023-06-10T16:24:29Z2023-06-10T16:24:29Z2023GONÇALVES, Remy Martins; HOTTZ, Eugenio D.; BOZZ, Patricia T. Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences. Current Research in Immunology, v.4, 100058, Apr. 2023.2590-2555https://www.arca.fiocruz.br/handle/icict/5898410.1016/j.crimmu.2023.100058engElsevier B.V.Síndrome pós-aguda de COVID-19 (PACS)Ativação plaquetáriaHipercoagulabilidadeTromboinflamaçãoPost-acute COVID-19 syndrome (PACS)Platelet activationHypercoagulabilityThromboinflammationAcute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequencesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Programa de Imunologia e Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal de Juiz de Fora. Departamento de Bioquímica. Laboratório de Imunotrombose. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Concerns for the long-term effects of COVID-19 infection have grown due to frequently reported persisting symptoms that can affect multiple systems for longer than 4 weeks after initial infection, a condition known as long-COVID-19 or post-acute COVID-19 syndrome (PACS). Even nonhospitalized survivors have an elevated risk for the development of thromboinflammatory-associated events, such as ischemic stroke and heart failure, pulmonary embolism and deep vein thrombosis. Recent findings point to the persistence of many mechanisms of hypercoagulability identified to be associated with disease severity and mortality in the acute phase of the disease, such as sustained inflammation and endotheliopathy, accompanied by abnormal fibrin generation and impaired fibrinolysis. Platelets seem to be central to the sustained hypercoagulable state, displaying hyperreactivity to stimuli and increased adhesive capacity. Platelets also contribute to elevated levels of thromboinflammatory mediators and pro-coagulant extracellular vesicles in individuals with ongoing PACS. Despite new advances in the understanding of mechanisms sustaining thromboinflammation in PACS, little is known about what triggers this persistence. In this graphical review, we provide a schematic representation of the known mechanisms and consequences of persisting thromboinflammation in COVID-19 survivors and summarize the hypothesized triggers maintaining this prothrombotic state.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58984/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRemyGonçalves_PatriciaBozza_EugenioHotttz_IOC_2023.pdfRemyGonçalves_PatriciaBozza_EugenioHotttz_IOC_2023.pdfapplication/pdf3954216https://www.arca.fiocruz.br/bitstream/icict/58984/2/RemyGon%c3%a7alves_PatriciaBozza_EugenioHotttz_IOC_2023.pdf5eb4aa2e3d1d92eb6049a7955d96d28eMD52icict/589842023-09-04 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dc.title.en_US.fl_str_mv Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
title Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
spellingShingle Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
Gonçalves, Remy Martins
Síndrome pós-aguda de COVID-19 (PACS)
Ativação plaquetária
Hipercoagulabilidade
Tromboinflamação
Post-acute COVID-19 syndrome (PACS)
Platelet activation
Hypercoagulability
Thromboinflammation
title_short Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
title_full Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
title_fullStr Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
title_full_unstemmed Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
title_sort Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
author Gonçalves, Remy Martins
author_facet Gonçalves, Remy Martins
Hottz, Eugenio D.
Bozza, Patricia T.
author_role author
author2 Hottz, Eugenio D.
Bozza, Patricia T.
author2_role author
author
dc.contributor.author.fl_str_mv Gonçalves, Remy Martins
Hottz, Eugenio D.
Bozza, Patricia T.
dc.subject.other.en_US.fl_str_mv Síndrome pós-aguda de COVID-19 (PACS)
Ativação plaquetária
Hipercoagulabilidade
Tromboinflamação
topic Síndrome pós-aguda de COVID-19 (PACS)
Ativação plaquetária
Hipercoagulabilidade
Tromboinflamação
Post-acute COVID-19 syndrome (PACS)
Platelet activation
Hypercoagulability
Thromboinflammation
dc.subject.en.en_US.fl_str_mv Post-acute COVID-19 syndrome (PACS)
Platelet activation
Hypercoagulability
Thromboinflammation
description Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Programa de Imunologia e Inflamação. Rio de Janeiro, RJ, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-10T16:24:29Z
dc.date.available.fl_str_mv 2023-06-10T16:24:29Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GONÇALVES, Remy Martins; HOTTZ, Eugenio D.; BOZZ, Patricia T. Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences. Current Research in Immunology, v.4, 100058, Apr. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58984
dc.identifier.issn.en_US.fl_str_mv 2590-2555
dc.identifier.doi.none.fl_str_mv 10.1016/j.crimmu.2023.100058
identifier_str_mv GONÇALVES, Remy Martins; HOTTZ, Eugenio D.; BOZZ, Patricia T. Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences. Current Research in Immunology, v.4, 100058, Apr. 2023.
2590-2555
10.1016/j.crimmu.2023.100058
url https://www.arca.fiocruz.br/handle/icict/58984
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58984/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58984/2/RemyGon%c3%a7alves_PatriciaBozza_EugenioHotttz_IOC_2023.pdf
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