Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/1898 |
Resumo: | Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil |
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Sá, Matheus Santos deCosta, José Fernando GustavoKrettli, Antoniana UrsiniZalis, Mariano GustavoMaia, Gabriela Lemos de AzevedoSette, Ivana Maria FechineCâmara, Celso de AmorimBarbosa Filho, José MariaHarley, Ana Maria GiuliettiSantos, Ricardo Ribeiro dosSoares, Milena Botelho Pereira2011-04-13T03:09:38Z2011-04-13T03:09:38Z2009SÁ, M. S. et al. Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice. Parasitol Research, v. 105, n.1, p.275-279, 2009.0932-0113https://www.arca.fiocruz.br/handle/icict/189810.1007/s00436-009-1394-0engAntimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCentro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilCentro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilCentro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, BrasilHospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrasilUniversidade Federal da Paraíba, João Pessoa, Paraíba, BrasilUniversidade Estadual da Paraíba, Campina Grande, Paraíba, BrasilUniversidade Federal Rural de Pernambuco, Recife, Pernambuco, BrasilUniversidade Federal da Paraíba, João Pessoa, Paraíba, BrasilUniversidade Estadual de Feira de Santana, Feira de Santana, Bahia, BrasilCentro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório de Engenharia Tecidual e Imunofarmacologia. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilMalaria is one of the most important tropical diseases and mainly affects populations living in developing countries. Reduced sensitivity of Plasmodium sp. to formerly recommended antimalarial drugs places an increasing burden on malaria control programs as well as on national health systems in endemic countries. The present study aims to evaluate the antimalarial activity of betulinic acid and its derivative compounds, betulonic acid, betulinic acid acetate, betulinic acid methyl ester, and betulinic acid methyl ester acetate. These substances showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro, with IC(50) values of 9.89, 10.01, 5.99, 51.58, and 45.79 microM, respectively. Mice infected with Plasmodium berghei and treated with betulinic acid acetate had a dose-dependent reduction of parasitemia. Our results indicate that betulinic acid and its derivative compounds are candidates for the development of new antimalarial drugs.MaláriaPlasmodium bergheiAntimaláricosPlasmodium falciparumTriterpenosRelação Dose-Resposta a Drogainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAntimalarial activity of betulinic acid and derivatives.pdfAntimalarial activity of betulinic acid and derivatives.pdfapplication/pdf140654https://www.arca.fiocruz.br/bitstream/icict/1898/1/Antimalarial%20activity%20of%20betulinic%20acid%20and%20derivatives.pdf63efcdfed845e5e6dd5cd247c4090c8dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1898/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTAntimalarial activity of betulinic acid and derivatives.pdf.txtAntimalarial activity of betulinic acid and derivatives.pdf.txtExtracted texttext/plain20459https://www.arca.fiocruz.br/bitstream/icict/1898/5/Antimalarial%20activity%20of%20betulinic%20acid%20and%20derivatives.pdf.txt366ce646120fd3ace2ee93432be80487MD55THUMBNAILAntimalarial activity of betulinic acid and derivatives.pdf.jpgAntimalarial activity of betulinic acid and derivatives.pdf.jpgGenerated Thumbnailimage/jpeg1691https://www.arca.fiocruz.br/bitstream/icict/1898/4/Antimalarial%20activity%20of%20betulinic%20acid%20and%20derivatives.pdf.jpgb78b5c132512e92aa6c39edf5164764dMD54icict/18982023-03-15 14:32:56.68oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice |
| title |
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice |
| spellingShingle |
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice Sá, Matheus Santos de Malária Plasmodium berghei Antimaláricos Plasmodium falciparum Triterpenos Relação Dose-Resposta a Droga |
| title_short |
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice |
| title_full |
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice |
| title_fullStr |
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice |
| title_full_unstemmed |
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice |
| title_sort |
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice |
| author |
Sá, Matheus Santos de |
| author_facet |
Sá, Matheus Santos de Costa, José Fernando Gustavo Krettli, Antoniana Ursini Zalis, Mariano Gustavo Maia, Gabriela Lemos de Azevedo Sette, Ivana Maria Fechine Câmara, Celso de Amorim Barbosa Filho, José Maria Harley, Ana Maria Giulietti Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Costa, José Fernando Gustavo Krettli, Antoniana Ursini Zalis, Mariano Gustavo Maia, Gabriela Lemos de Azevedo Sette, Ivana Maria Fechine Câmara, Celso de Amorim Barbosa Filho, José Maria Harley, Ana Maria Giulietti Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sá, Matheus Santos de Costa, José Fernando Gustavo Krettli, Antoniana Ursini Zalis, Mariano Gustavo Maia, Gabriela Lemos de Azevedo Sette, Ivana Maria Fechine Câmara, Celso de Amorim Barbosa Filho, José Maria Harley, Ana Maria Giulietti Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| dc.subject.decs.pt_BR.fl_str_mv |
Malária Plasmodium berghei Antimaláricos Plasmodium falciparum Triterpenos Relação Dose-Resposta a Droga |
| topic |
Malária Plasmodium berghei Antimaláricos Plasmodium falciparum Triterpenos Relação Dose-Resposta a Droga |
| description |
Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil |
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2009 |
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2009 |
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2011-04-13T03:09:38Z |
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2011-04-13T03:09:38Z |
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info:eu-repo/semantics/article |
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SÁ, M. S. et al. Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice. Parasitol Research, v. 105, n.1, p.275-279, 2009. |
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10.1007/s00436-009-1394-0 |
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SÁ, M. S. et al. Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice. Parasitol Research, v. 105, n.1, p.275-279, 2009. 0932-0113 10.1007/s00436-009-1394-0 |
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