Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil

Detalhes bibliográficos
Autor(a) principal: Nogueira, B. M. F.
Data de Publicação: 2018
Outros Autores: Rolla, V. C., Akrami, K. M., Kiene, S. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33671
Resumo: San Diego State University. Division of Epidemiology and Biostatistics. San Diego, CA, USA.
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spelling Nogueira, B. M. F.Rolla, V. C.Akrami, K. M.Kiene, S. M.2019-06-26T11:59:53Z2019-06-26T11:59:53Z2018NOGUEIRA, Betânia M. F. et al. Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil. Plos One, v. 13, n. 4, p. 1-14, Apr. 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/3367110.1371/journal.pone.01954091932-6203engPublic Library of ScienceFactors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSan Diego State University. Division of Epidemiology and Biostatistics. San Diego, CA, USA.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of California, San Diego. Division of Infectious Diseases. San Diego, CA, USA.San Diego State University. Division of Epidemiology and Biostatistics. San Diego, CA, USA.Background: Worldwide, about 11% of Tuberculosis (TB) cases occur in people living with HIV (PLHIV) and it is the leading cause of death in this population. An important step towards reducing the incidence and mortality of TB in PLHIV is to reduce the time from onset of symptoms to treatment. Factors related to TB treatment delay therefore need to be understood. Methods: Using data from a prospective cohort study of patients diagnosed with TB at the National Institute of Infectious Disease, at the Oswaldo Cruz Foundation, Rio de Janeiro, Brazil we conducted a survival analysis to identify factors associated with patient and health care treatment delay. In our analysis we included patients who were co-infected with TB and HIV (n = 201). Patients were followed during the course of their TB treatment and information regarding duration of symptoms, sociodemographics and clinical characteristics were collected at the baseline visit. Results: The median time from onset of initial symptoms to prescription of TB treatment (total delay) was 82 days. From initiation of symptoms to first visit at INI clinic (patient delay), the median was 51 days. From first visit to initiation of treatment (health care delay) the median was 16 days. Illiteracy was associated with greater patient delay [Hazard Ratio (HR) = 2.25, CI 95% 1.29–3.94]. Having had a previous episode of TB (HR = 0.53, CI 95% 0.37–0.74) and being married (HR = 0.71, CI 95% 0.54–0.94) were inversely related to patient delay. Illiteracy was also associated with greater health care delay (HR = 2.83, CI 95% 1.25–5.47) in contrast to high viral load (HR = 0.37, CI 95% 0.24–0.54) and weight loss greater than 10% (HR = 0.54, CI 95% 0.37–0.8), both of which were inversely related to health care delay. Conclusions: This study highlights the existence of factors that lead to greater risk of delayed treatment of TB among patients co-infected with HIV and TB. These include factors that can be assessed through targeted interventions which have implications for improving treatment outcomes and, through reduced duration of infectiousness, reduce the incidence of TB in Brazil.TuberculosisHIVPatients co-infectedBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/33671/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Nogueira_Betânia_etal_INI_2018.pdfve_Nogueira_Betânia_etal_INI_2018.pdfapplication/pdf1433462https://www.arca.fiocruz.br/bitstream/icict/33671/2/ve_Nogueira_Bet%c3%a2nia_etal_INI_2018.pdfa3e324acced02e97bc357d6580ddef20MD52ve_Nogueira_Betânia_etal_INI_corr_2018.pdfve_Nogueira_Betânia_etal_INI_corr_2018.pdfapplication/pdf217100https://www.arca.fiocruz.br/bitstream/icict/33671/3/ve_Nogueira_Bet%c3%a2nia_etal_INI_corr_2018.pdfd26c3b22938f589d73f3dfbb8448c2e5MD53TEXTve_Nogueira_Betânia_etal_INI_2018.pdf.txtve_Nogueira_Betânia_etal_INI_2018.pdf.txtExtracted texttext/plain47114https://www.arca.fiocruz.br/bitstream/icict/33671/4/ve_Nogueira_Bet%c3%a2nia_etal_INI_2018.pdf.txt74022a6d4c2f6e716a66e8a3477ab7b2MD54ve_Nogueira_Betânia_etal_INI_corr_2018.pdf.txtve_Nogueira_Betânia_etal_INI_corr_2018.pdf.txtExtracted texttext/plain1426https://www.arca.fiocruz.br/bitstream/icict/33671/5/ve_Nogueira_Bet%c3%a2nia_etal_INI_corr_2018.pdf.txt01f0457fc9ea9799ac0df839ef31fa5dMD55icict/336712019-06-30 20:44:17.332oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-30T23:44:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil
title Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil
spellingShingle Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil
Nogueira, B. M. F.
Tuberculosis
HIV
Patients co-infected
Brazil
title_short Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil
title_full Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil
title_fullStr Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil
title_full_unstemmed Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil
title_sort Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil
author Nogueira, B. M. F.
author_facet Nogueira, B. M. F.
Rolla, V. C.
Akrami, K. M.
Kiene, S. M.
author_role author
author2 Rolla, V. C.
Akrami, K. M.
Kiene, S. M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Nogueira, B. M. F.
Rolla, V. C.
Akrami, K. M.
Kiene, S. M.
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
HIV
Patients co-infected
Brazil
topic Tuberculosis
HIV
Patients co-infected
Brazil
description San Diego State University. Division of Epidemiology and Biostatistics. San Diego, CA, USA.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-06-26T11:59:53Z
dc.date.available.fl_str_mv 2019-06-26T11:59:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv NOGUEIRA, Betânia M. F. et al. Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil. Plos One, v. 13, n. 4, p. 1-14, Apr. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33671
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0195409
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv NOGUEIRA, Betânia M. F. et al. Factors associated with tuberculosis treatment delay in patients co-infected with HIV in a high prevalence area in Brazil. Plos One, v. 13, n. 4, p. 1-14, Apr. 2018.
1932-6203
10.1371/journal.pone.0195409
url https://www.arca.fiocruz.br/handle/icict/33671
dc.language.iso.fl_str_mv eng
language eng
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