The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor

Detalhes bibliográficos
Autor(a) principal: Soares, Milena Botelho Pereira
Data de Publicação: 1998
Outros Autores: Titus, Richard G, Shoemaker, Charles B, David, John R, Bozza, Marcelo Torres
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20674
Resumo: Soares, Milena Botelho Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Soares, Milena Botelho PereiraTitus, Richard GShoemaker, Charles BDavid, John RBozza, Marcelo Torres2017-08-17T18:37:30Z2017-08-17T18:37:30Z1998SOARES, M. B. P. et al. The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor. Journal of Immunology, v. 160, p. 1811-1816, 1998.0022-1767https://www.arca.fiocruz.br/handle/icict/20674Soares, Milena Botelho Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.National Institutes of Health Grants AI 22532–13 and AI 27511–09.Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USAColorado State University. College of Veterinary Medicine and Biomedical Sciences. Department of Pathology. Fort Collins, ColoradoHarvard School of Public Health. Department of Tropical Public Health. Boston, MA, USAHarvard School of Public Health. Department of Tropical Public Health. Boston, MA, USAHarvard School of Public Health. Department of Tropical Public Health. Boston, MA, USAMaxadilan is a vasodilatory peptide encoded by a gene cloned from Lutzomyia longipalpis salivary glands. In this study we investigated the effects of maxadilan on macrophage functions. Maxadilan treatment of LPS-stimulated BALB/c macrophages inhibited TNF-! release but increased IL-6. Further, it also induced IL-6 release in a dose-dependent manner from unstimulated macrophages. Maxadilan increased production of PGE2, and the inhibition of TNF-! was completely abrogated by indomethacin. Others have recently shown that maxadilan is a selective agonist of the pituitary adenylate cyclase-activating polypeptide (PACAP) type I receptor. Treatment with the receptor antagonist PACAP 6–38 blocked maxadilan activities on macrophages. The natural endogenous ligand, PACAP 38, had the same effects as maxadilan on TNF-! and IL-6 production. Finally, in a dose- and time-dependent fashion, maxadilan induced the intracellular accumulation of cAMP in macrophages. Taken together, the results presented here indicate a modulatory effect of ligands of PACAP type I receptor on cytokine production by macrophages and suggest that activation of this receptor, with the subsequent elevation of intracellular cAMP in macrophages, could participate in a negative-feedback mechanism that controls certain inflammatory responsesengAmerican Association of ImmunologistsGlandulas salivaresVasodilatadorLutzomyiaTratamentoMacrófagosSalivary glandsvasodilatoryLutzomyiaTreatmentMacrophagesThe Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor
title The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor
spellingShingle The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor
Soares, Milena Botelho Pereira
Glandulas salivares
Vasodilatador
Lutzomyia
Tratamento
Macrófagos
Salivary glands
vasodilatory
Lutzomyia
Treatment
Macrophages
title_short The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor
title_full The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor
title_fullStr The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor
title_full_unstemmed The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor
title_sort The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor
author Soares, Milena Botelho Pereira
author_facet Soares, Milena Botelho Pereira
Titus, Richard G
Shoemaker, Charles B
David, John R
Bozza, Marcelo Torres
author_role author
author2 Titus, Richard G
Shoemaker, Charles B
David, John R
Bozza, Marcelo Torres
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Soares, Milena Botelho Pereira
Titus, Richard G
Shoemaker, Charles B
David, John R
Bozza, Marcelo Torres
dc.subject.other.pt_BR.fl_str_mv Glandulas salivares
Vasodilatador
Lutzomyia
Tratamento
Macrófagos
topic Glandulas salivares
Vasodilatador
Lutzomyia
Tratamento
Macrófagos
Salivary glands
vasodilatory
Lutzomyia
Treatment
Macrophages
dc.subject.en.pt_BR.fl_str_mv Salivary glands
vasodilatory
Lutzomyia
Treatment
Macrophages
description Soares, Milena Botelho Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2017-08-17T18:37:30Z
dc.date.available.fl_str_mv 2017-08-17T18:37:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, M. B. P. et al. The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor. Journal of Immunology, v. 160, p. 1811-1816, 1998.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20674
dc.identifier.issn.pt_BR.fl_str_mv 0022-1767
identifier_str_mv SOARES, M. B. P. et al. The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-! and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor. Journal of Immunology, v. 160, p. 1811-1816, 1998.
0022-1767
url https://www.arca.fiocruz.br/handle/icict/20674
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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