The role of short-chain fatty acids from gut microbiota in gut-brain communication

Detalhes bibliográficos
Autor(a) principal: Silva, Ygor Parladore
Data de Publicação: 2020
Outros Autores: Bernardi, Andressa, Frozza, Rudimiar Luiz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41503
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
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spelling Silva, Ygor ParladoreBernardi, AndressaFrozza, Rudimiar Luiz2020-06-03T15:15:50Z2020-06-03T15:15:50Z2020SILVA, Ygor Parladore; BERNARDI, Andressa; FROZZA, Rudimar Luiz. The role of short-chain fatty acids from Gut Microbiota in Gut-Brain communication. Frontiers in Endocrinology, v. 11, Article 25, 14p, Jan. 2020.1664-2392https://www.arca.fiocruz.br/handle/icict/41503engFrontiers MediaSistema nervoso centralNeuroinflamaçãoMicróbio intestinalÁcidos graxos de cadeia curtaCentral nervous systemNeuroinflammationGut-brain axisGut microbiotaShort-chain fatty acidsThe role of short-chain fatty acids from gut microbiota in gut-brain communicationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions. In recent years, there has been growing recognition of the involvement of the gut microbiota in the modulation of multiple neurochemical pathways through the highly interconnected gut-brain axis. Although amazing scientific breakthroughs over the last few years have expanded our knowledge on the communication between microbes and their hosts, the underpinnings of microbiota-gut-brain crosstalk remain to be determined. Short-chain fatty acids (SCFAs), the main metabolites produced in the colon by bacterial fermentation of dietary fibers and resistant starch, are speculated to play a key role in neuro-immunoendocrine regulation. However, the underlying mechanisms through which SCFAs might influence brain physiology and behavior have not been fully elucidated. In this review, we outline the current knowledge about the involvement of SCFAs in microbiota-gut-brain interactions. We also highlight how the development of future treatments for central nervous system (CNS) disorders can take advantage of the intimate and mutual interactions of the gut microbiota with the brain by exploring the role of SCFAs in the regulation of neuro-immunoendocrine function.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41503/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRudimarL_Frozza_etal_IOC_2020.pdfRudimarL_Frozza_etal_IOC_2020.pdfapplication/pdf862317https://www.arca.fiocruz.br/bitstream/icict/41503/2/RudimarL_Frozza_etal_IOC_2020.pdf64d67634617f4ba5735f9778677ec0ecMD52TEXTRudimarL_Frozza_etal_IOC_2020.pdf.txtRudimarL_Frozza_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The role of short-chain fatty acids from gut microbiota in gut-brain communication
title The role of short-chain fatty acids from gut microbiota in gut-brain communication
spellingShingle The role of short-chain fatty acids from gut microbiota in gut-brain communication
Silva, Ygor Parladore
Sistema nervoso central
Neuroinflamação
Micróbio intestinal
Ácidos graxos de cadeia curta
Central nervous system
Neuroinflammation
Gut-brain axis
Gut microbiota
Short-chain fatty acids
title_short The role of short-chain fatty acids from gut microbiota in gut-brain communication
title_full The role of short-chain fatty acids from gut microbiota in gut-brain communication
title_fullStr The role of short-chain fatty acids from gut microbiota in gut-brain communication
title_full_unstemmed The role of short-chain fatty acids from gut microbiota in gut-brain communication
title_sort The role of short-chain fatty acids from gut microbiota in gut-brain communication
author Silva, Ygor Parladore
author_facet Silva, Ygor Parladore
Bernardi, Andressa
Frozza, Rudimiar Luiz
author_role author
author2 Bernardi, Andressa
Frozza, Rudimiar Luiz
author2_role author
author
dc.contributor.author.fl_str_mv Silva, Ygor Parladore
Bernardi, Andressa
Frozza, Rudimiar Luiz
dc.subject.other.pt_BR.fl_str_mv Sistema nervoso central
Neuroinflamação
Micróbio intestinal
Ácidos graxos de cadeia curta
topic Sistema nervoso central
Neuroinflamação
Micróbio intestinal
Ácidos graxos de cadeia curta
Central nervous system
Neuroinflammation
Gut-brain axis
Gut microbiota
Short-chain fatty acids
dc.subject.en.pt_BR.fl_str_mv Central nervous system
Neuroinflammation
Gut-brain axis
Gut microbiota
Short-chain fatty acids
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-06-03T15:15:50Z
dc.date.available.fl_str_mv 2020-06-03T15:15:50Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Ygor Parladore; BERNARDI, Andressa; FROZZA, Rudimar Luiz. The role of short-chain fatty acids from Gut Microbiota in Gut-Brain communication. Frontiers in Endocrinology, v. 11, Article 25, 14p, Jan. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41503
dc.identifier.issn.pt_BR.fl_str_mv 1664-2392
identifier_str_mv SILVA, Ygor Parladore; BERNARDI, Andressa; FROZZA, Rudimar Luiz. The role of short-chain fatty acids from Gut Microbiota in Gut-Brain communication. Frontiers in Endocrinology, v. 11, Article 25, 14p, Jan. 2020.
1664-2392
url https://www.arca.fiocruz.br/handle/icict/41503
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/41503/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/41503/2/RudimarL_Frozza_etal_IOC_2020.pdf
https://www.arca.fiocruz.br/bitstream/icict/41503/3/RudimarL_Frozza_etal_IOC_2020.pdf.txt
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