Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients

Detalhes bibliográficos
Autor(a) principal: Malfussi, Hamilton
Data de Publicação: 2019
Outros Autores: Santana, Iara Vidigal, Gasparotto, Juciano, Righy, Cassia, Tomasi, Cristiane Damiani, Gelain, Daniel Pens, Bozza, Fernando A., Walz, Roger, Dal-Pizzol, Felipe, Ritter, Cristiane
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37907
Resumo: Universidade Federal de Santa Catarina. Programa de Pós-Graduação em Ciências Médicas. Florianópolis, SC, Brasil.
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spelling Malfussi, HamiltonSantana, Iara VidigalGasparotto, JucianoRighy, CassiaTomasi, Cristiane DamianiGelain, Daniel PensBozza, Fernando A.Walz, RogerDal-Pizzol, FelipeRitter, Cristiane2019-12-12T15:16:33Z2019-12-12T15:16:33Z2019MALFUSSI, Hamilton et al. Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients. Frontiers in Neurology, p. 1-6, v. 10, Mar. 2019.1664-2295https://www.arca.fiocruz.br/handle/icict/3790710.3389/fneur.2019.002211664-2295engFrontiers MediaAnti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Santa Catarina. Programa de Pós-Graduação em Ciências Médicas. Florianópolis, SC, Brasil.Universidade do Extremo Sul Catarinense. Laboratório de Fisiopatologia Experimental. Criciúma, SC, Brasil.Universidade Federal do Rio Grande do Sul. Centro de Estudos em Estresse Oxidativo. Instituto de Ciências Básicas da Saúde. Departamento de Bioquímica. Porto Alegre, RS, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade do Extremo Sul Catarinense. Laboratório de Fisiopatologia Experimental. Criciúma, SC, Brasil / Universidade do Extremo Sul Catarinense. Grupo de Pesquisa em Gestão do Cuidado, Integralidade e Educação na Saúde. Programa de Pós-Graduação em Saúde Coletiva. Criciúma, SC, Brasil.Universidade Federal do Rio Grande do Sul. Centro de Estudos em Estresse Oxidativo. Instituto de Ciências Básicas da Saúde. Departamento de Bioquímica. Porto Alegre, RS, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil.Centro de Cirurgia de Epilepsia de Santa Catarina. Departamento de Clínica Médica. Serviço de Neurologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Hospital Universitário. Centro de Neurociências Aplicadas. Florianópolis, SC, Brasil.Universidade do Extremo Sul Catarinense. Laboratório de Fisiopatologia Experimental. Criciúma, SC, Brasil / Hospital São José. Criciúma, SC, Brasil.Universidade do Extremo Sul Catarinense. Laboratório de Fisiopatologia Experimental. Criciúma, SC, Brasil / Hospital São José. Criciúma, SC, Brasil.The presence of autoantibodies against neuronal cell surface or synaptic proteins and their relationship to autoimmune encephalitis have recently been characterized. These autoantibodies have been also reported in other pathologic conditions; however, their role during sepsis is not known. This study detected the presence of autoantibodies against neuronal cell surface or synaptic proteins in the serum of septic patients and determined their relationship to the occurrence of brain dysfunction and mortality. This prospective, observational cohort study was performed in four Brazilian intensive care units (ICUs). Sixty patients with community-acquired severe sepsis or septic shock admitted to the ICU were included. Blood samples were collected from patients within 24 h of ICU admission. Antibodies to six neuronal proteins were assessed, including glutamate receptors (types NMDA, AMPA1, and AMPA2); voltage-gated potassium channel complex (VGKC) proteins, leucine-rich glioma-inactivated protein 1 (LGI1), and contactin-associated protein-2 (Caspr2), as well as the GABAB1 receptor. There was no independent association between any of the measured autoantibodies and the occurrence of brain dysfunction (delirium or coma). However, there was an independent and significant relationship between anti-NMDAR fluorescence intensity and hospital mortality. In conclusion, anti-NMDAR was independently associated with hospital mortality but none of the measured antibodies were associated with brain dysfunction in septic patients.DeliriumBrain dysfunctionSepsisNeuronal autoantibodiesICUinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/37907/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Malfussi_Hamilton_etal_INI_2019.pdfve_Malfussi_Hamilton_etal_INI_2019.pdfapplication/pdf309585https://www.arca.fiocruz.br/bitstream/icict/37907/2/ve_Malfussi_Hamilton_etal_INI_2019.pdf6bbd01dbde8bd9ed1b4eaa83daf07da4MD52TEXTve_Malfussi_Hamilton_etal_INI_2019.pdf.txtve_Malfussi_Hamilton_etal_INI_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients
title Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients
spellingShingle Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients
Malfussi, Hamilton
Delirium
Brain dysfunction
Sepsis
Neuronal autoantibodies
ICU
title_short Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients
title_full Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients
title_fullStr Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients
title_full_unstemmed Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients
title_sort Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients
author Malfussi, Hamilton
author_facet Malfussi, Hamilton
Santana, Iara Vidigal
Gasparotto, Juciano
Righy, Cassia
Tomasi, Cristiane Damiani
Gelain, Daniel Pens
Bozza, Fernando A.
Walz, Roger
Dal-Pizzol, Felipe
Ritter, Cristiane
author_role author
author2 Santana, Iara Vidigal
Gasparotto, Juciano
Righy, Cassia
Tomasi, Cristiane Damiani
Gelain, Daniel Pens
Bozza, Fernando A.
Walz, Roger
Dal-Pizzol, Felipe
Ritter, Cristiane
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Malfussi, Hamilton
Santana, Iara Vidigal
Gasparotto, Juciano
Righy, Cassia
Tomasi, Cristiane Damiani
Gelain, Daniel Pens
Bozza, Fernando A.
Walz, Roger
Dal-Pizzol, Felipe
Ritter, Cristiane
dc.subject.en.pt_BR.fl_str_mv Delirium
Brain dysfunction
Sepsis
Neuronal autoantibodies
ICU
topic Delirium
Brain dysfunction
Sepsis
Neuronal autoantibodies
ICU
description Universidade Federal de Santa Catarina. Programa de Pós-Graduação em Ciências Médicas. Florianópolis, SC, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-12-12T15:16:33Z
dc.date.available.fl_str_mv 2019-12-12T15:16:33Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MALFUSSI, Hamilton et al. Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients. Frontiers in Neurology, p. 1-6, v. 10, Mar. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37907
dc.identifier.issn.pt_BR.fl_str_mv 1664-2295
dc.identifier.doi.none.fl_str_mv 10.3389/fneur.2019.00221
dc.identifier.eissn.none.fl_str_mv 1664-2295
identifier_str_mv MALFUSSI, Hamilton et al. Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients. Frontiers in Neurology, p. 1-6, v. 10, Mar. 2019.
1664-2295
10.3389/fneur.2019.00221
url https://www.arca.fiocruz.br/handle/icict/37907
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/37907/1/license.txt
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