Genetic variants in RORA are associated with asthma and allergy markers in an admixed population

Detalhes bibliográficos
Autor(a) principal: Lima, Louise Correia
Data de Publicação: 2018
Outros Autores: Queiroz, Gerson de Almeida, Costa, Ryan dos Santos, Neves, Neuza Maria Alcantara, Marques, Cíntia Rodrigues, Costa, Gustavo Nunes de Oliveira, Barreto, Maurício Lima, Figueiredo, Camila Alexandrina Viana, Carneiro, Valdirene Leão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28147
Resumo: Barreto, Mauricio Lima. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Lima, Louise CorreiaQueiroz, Gerson de AlmeidaCosta, Ryan dos SantosNeves, Neuza Maria AlcantaraMarques, Cíntia RodriguesCosta, Gustavo Nunes de OliveiraBarreto, Maurício LimaFigueiredo, Camila Alexandrina VianaCarneiro, Valdirene Leão2018-08-15T14:16:45Z2018-08-15T14:16:45Z2019LIMA, Louise Correia et al. Genetic variants in RORA are associated with asthma and allergy markers in an admixed population. Cytokine, v. 113, p. 177-184, 2019.1043-4666https://www.arca.fiocruz.br/handle/icict/2814710.1016/j.cyto.2018.07.004Barreto, Mauricio Lima. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.O artigo encontra-se disponível em acesso aberto para download no site do Editor.CNPq National Research Council - Brazil and FAPESB State of Bahia, Brazil Research Council.Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil.Asthma and allergy affect hundreds of millions of people from childhood to old age. In most of them, the inflammatory process of respiratory allergies involves the participation of type 2 cytokines, derived from T helper-2 (Th2)-cell, and Group 2 Innate Lymphoid (ILC2) Cells. An efficient memory Th2 cell response is dependent on IL-13 produced by ILC2s, causing allergic lung inflammation and elevated serum levels of immunoglobulin E. ILC2 cells are derived from common lymphoid progenitors and their growing depends on the transcription factor RORA. The aim of this work was to identify genetic variants in RORA associated with asthma phenotypes and allergy markers. Genomic DNA samples of 1246 individuals participating from Social Changes Asthma and Allergy in Latin America Program (SCAALA) have been genotyped using Illumina Human 2.5 Omni Beadchip. Logistics regressions have been performed to analyze the association among RORA variants and asthma, skin prick tests (SPT), specific IgE and type 2 cytokine production. Twelve single nucleotide variants (SNVs) were significantly associated with atopy (P < 0.01), in which four of them, rs10162630, rs17191519, rs17270243, and rs55796775 and their haplotypes were strongly and positively associated (P < 0.001). Furthermore, these variants increased the RORA gene expression in silico analysis. Other SNVs in RORA were associated with allergy markers, atopic and non-atopic asthma. Therefore, it is believed that variants in RORA gene may influence immunologic features of asthma and allergies and could be possible targets for future treatment of allergic diseases.engElsevierPolimorfismoSensibilização atópicaRORAAsmaPolymorphismAtopic sensitizationRORAAsthmaGenetic variants in RORA are associated with asthma and allergy markers in an admixed populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28147/1/license.txt5a560609d32a3863062d77ff32785d58MD51TEXTLima LC Genetic variants in RORA are associated .....pdf.txtLima LC Genetic variants in RORA are associated .....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
title Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
spellingShingle Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
Lima, Louise Correia
Polimorfismo
Sensibilização atópica
RORA
Asma
Polymorphism
Atopic sensitization
RORA
Asthma
title_short Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
title_full Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
title_fullStr Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
title_full_unstemmed Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
title_sort Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
author Lima, Louise Correia
author_facet Lima, Louise Correia
Queiroz, Gerson de Almeida
Costa, Ryan dos Santos
Neves, Neuza Maria Alcantara
Marques, Cíntia Rodrigues
Costa, Gustavo Nunes de Oliveira
Barreto, Maurício Lima
Figueiredo, Camila Alexandrina Viana
Carneiro, Valdirene Leão
author_role author
author2 Queiroz, Gerson de Almeida
Costa, Ryan dos Santos
Neves, Neuza Maria Alcantara
Marques, Cíntia Rodrigues
Costa, Gustavo Nunes de Oliveira
Barreto, Maurício Lima
Figueiredo, Camila Alexandrina Viana
Carneiro, Valdirene Leão
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Louise Correia
Queiroz, Gerson de Almeida
Costa, Ryan dos Santos
Neves, Neuza Maria Alcantara
Marques, Cíntia Rodrigues
Costa, Gustavo Nunes de Oliveira
Barreto, Maurício Lima
Figueiredo, Camila Alexandrina Viana
Carneiro, Valdirene Leão
dc.subject.other.pt_BR.fl_str_mv Polimorfismo
Sensibilização atópica
RORA
Asma
topic Polimorfismo
Sensibilização atópica
RORA
Asma
Polymorphism
Atopic sensitization
RORA
Asthma
dc.subject.en.pt_BR.fl_str_mv Polymorphism
Atopic sensitization
RORA
Asthma
description Barreto, Mauricio Lima. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-08-15T14:16:45Z
dc.date.available.fl_str_mv 2018-08-15T14:16:45Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, Louise Correia et al. Genetic variants in RORA are associated with asthma and allergy markers in an admixed population. Cytokine, v. 113, p. 177-184, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28147
dc.identifier.issn.pt_BR.fl_str_mv 1043-4666
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.cyto.2018.07.004
identifier_str_mv LIMA, Louise Correia et al. Genetic variants in RORA are associated with asthma and allergy markers in an admixed population. Cytokine, v. 113, p. 177-184, 2019.
1043-4666
10.1016/j.cyto.2018.07.004
url https://www.arca.fiocruz.br/handle/icict/28147
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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