Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Detalhes bibliográficos
Autor(a) principal: Young, William J
Data de Publicação: 2023
Outros Autores: Costa, Maria Fernanda Furtado Lima, Diversos autores
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58224
Resumo: Jeffrey Haessler Public Health Sciences Division. Fred Hutchinson Cancer Center. Seattle, WA, USA. Jan-Walter Benjamins University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, the Netherlands. Linda Repetto Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland. Jie Yao Institute for Translational Genomics and Population Sciences. Torrance, CA, USA./The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA. Aaron Isaacs Dept. of Physiology. Cardiovascular Research Institute Maastricht. Maastricht University, Maastricht. the Netherlands/Center for Systems Biology. Maastricht University. Maastricht, the Netherlands. Andrew R Harper Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Julia Ramirez William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK /Institute of Cardiovascular Sciences. University of College London. London, UK/Aragon Institute of Engineering Research. University of Zaragoza. Zaragoza, Spain/Center of Biomedical Research Network. Bioengineering, Biomaterials and Nanomedicine. Zaragoza, Spain. Sophie Garnier Sorbonne Universite. Research Unit on Cardiovascular Disorders. Metabolism and Nutrition. Team Genomics & Pathophysiology of Cardiovascular Disease. Paris, Franc/ICAN Institute for Cardiometabolism and Nutrition. Paris, France. Stefan van Duijvenboden William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/ Institute of Cardiovascular Sciences. University of College London. London, UK. Antoine R Baldassari Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Maria Pina Concas Institute for Maternal and Child Health - IRCCS "Burlo Garofolo". Trieste, Italy. ThuyVy Duong McKusick-Nathans Institute. Department of Genetic Medicine. Johns Hopkins University School of Medicine. Baltimore, MD, USA. Luisa Foco Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy. Jonas L Isaksen Laboratory of Experimental Cardiology. Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Hao Mei Department of Data Science. University of Mississippi Medical Center. Jackson, MS, USA. Raymond Noordam Department of Internal Medicine. section of Gerontology and Geriatrics. Leiden University Medical Center. Leiden, the Netherlands. Casia Nursyifa Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Anne Richmond MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland. Meddly L Santolalla Department of Genetics, Ecology and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Emerge, Emerging Diseases and Climate Change Research Unit. School of Public Health and Administration. Universidad Peruana Cayetano Heredia. Lima, Peru. Colleen M Sitlani Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Negin Soroush Department of Epidemiology. Erasmus Medical Center. Rotterdam, the Netherlands. Sébastien Thériault Population Health Research Institute. McMaster University. Hamilton, ON, Canada/Department of Molecular Biology. Medical Biochemistry and Pathology. Université Laval, Quebec. QC, Canada. Stella Trompet Department of Internal Medicine. section of Gerontology and Geriatrics. Leiden University Medical Center. Leiden, the Netherlands/Department of Cardiology. Leiden University Medical Center. Leiden, the Netherlands. Stefanie Aeschbacher Julius Global Health. University Utrecht Medical Center. Utrecht, the Netherlands. Fariba Ahmadizar 27 32, Alvaro Alonso Department of Epidemiology. Rollins School of Public Health. Emory University. Atlanta, GA, USA. Jennifer A Brody Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Archie Campbell Usher Institute. University of Edinburgh. Edinburgh, UK/Health Data Research UK. University of Edinburgh., Edinburgh, UK/Centre for Genomic and Experimental Medicine. Institute of Genéticos and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK. Adolfo Correa Departments of Medicine. Pediatrics and Population Health Science. University of Mississippi Medical Center. Jackson, MS, USA. Dawood Darbar Department of Medicine. University of Illinois at Chicago. Chicago, IL, USA. Antonio De Luca Cardiothoracovascular Department. Division of Cardiology. Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste. Trieste, Italy. Jean-François Deleuze Université Paris-Saclay. Centre National de Recherche en Génomique Humaine. Evry, France/Laboratory of Excellence GENMED. Paris, France/Centre d'Etude du Polymorphisme Humain. Fondation Jean Dausset. Paris, France. Christina Ellervik Department of Data and Data Support, Region Zealand, 4180, Sorø, Denmark/Department of Clinical Medicine. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark/Department of Laboratory Medicine. Boston Children's Hospital. Harvard Medical School. Boston, MA, USA. Christian Fuchsberger Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy/Department of Biostatistics. University of Michigan School of Public Health, Ann Arbor, MI, USA/ Center for Statistical Genetics, University of Michigan School of Public Health. Ann Arbor, MI, USA. Anuj Goel Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Christopher Grace Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Xiuqing Guo Institute for Translational Genomics and Population Sciences. Torrance, CA, USA./The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics. Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics. David Geffen School of Medicine at UCLA. Los Angeles, CA, USA. Torben Hansen Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Susan R Heckbert Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA/Department of Epidemiology. University of Washington. Seattle, WA, USA. Rebecca D Jackson Center for Clinical and Translational Science. Ohio State Medical Center. Columbus, OH, USA. Jan A Kors Department of Medical Informatics. Erasmus University Medical Center. Rotterdam, the Netherlands. Allan Linneberg Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital. København, Denmark/Department of Clinical Medicine. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Peter W Macfarlane Institute of Health and Wellbeing. School of Health and Wellbeing. College of Medical, Veterinary and Life Sciences. University of Glasgow, Glasgow, UK. Alanna C Morrison Human Genetics Center. Department of Epidemiology, Human Genetics, and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston. Houston, TX, USA. Pau Navarro MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland David J Porteous Centre for Genomic and Experimental Medicine. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK/Centre for Cognitive Ageing and Cognitive Epidemiology. University of Edinburgh. Edinburgh, UK. Peter P Pramstaller Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy/Department of Neurology. University of Lübeck. Lübeck, Germany. Alexander P Reiner Department of Epidemiology. University of Washington. Seattle, WA, USA/ Fred Hutchinson Cancer Center. University of Washington. Seattle, WA, USA. Lorenz Risch Labormedizinisches zentrum Dr. Risch. Vaduz, Liechtenstein/Faculty of Medical Sciences. Private University in the Principality of Liechtenstein. Triesen, Liechtenstein/Center of Laboratory Medicine. University Institute of Clinical Chemistry. University of Bern, Inselspital. Bern, Switzerland. Ulrich Schotten Dept. of Physiology. Cardiovascular Research Institute Maastricht. Maastricht University, Maastricht. the Netherlands. Xia Shen Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland/Department of Medical Epidemiology and Biostatistics. Karolinska Institutet. Stockholm, Sweden/Greater Bay Area Institute of Precision Medicine. Fudan University. Nansha District, Guangzhou, China. Gianfranco Sinagra Cardiothoracovascular Department. Division of Cardiology. Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste. Trieste, Italy. Elsayed Z Soliman Epidemiological Cardiology Research Center. Wake Forest School of Medicine. Winston Salem, NC, USA. Monika Stoll Maastricht Center for Systems Biology. Maastricht University. Maastricht, the Netherlands/Dept. of Biochemistry. Cardiovascular Research Institute Maastricht. Maastricht University. Maastricht, the Netherlands/Institute of Human Genetics, Genetic Epidemiology, University of Muenster, Muenster, Germany. Eduardo Tarazona-Santos Department of Genetics, Ecology and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. Andrew Tinker William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK. Katerina Trajanoska Department of Internal Medicine. Erasmus Medical Center. Rotterdam, the Netherlands. Eric Villard Sorbonne Universite. Research Unit on Cardiovascular Disorders. Metabolism and Nutrition. Team Genomics & Pathophysiology of Cardiovascular Disease. Paris, France/ICAN Institute for Cardiometabolism and Nutrition. Paris, France. Helen R Warren William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK. Eric A Whitsel Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA/ Department of Medicine. School of Medicine. University of North Carolina. Chapel Hill, NC, USA. Kerri L Wiggins Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Dan E Arking McKusick-Nathans Institute. Department of Genetic Medicine. Johns Hopkins University School of Medicine. Baltimore, MD, USA. Christy L Avery Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. David Conen Population Health Research Institute. McMaster University. Hamilton, ON, Canada. Giorgia Girotto Institute for Maternal and Child Health - IRCCS "Burlo Garofolo". Trieste, Italy/ Department of Medical. Surgery and Health Sciences. University of Trieste. Trieste, Italy. Niels Grarup Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Caroline Hayward MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK. J Wouter Jukema Department of Cardiology. Leiden University Medical Center. Leiden, the Netherlands/ Netherlands Heart Institute. Utrecht, the Netherlands/Durrer Center for Cardiovascular Research. Amsterdam, the Netherlands. Dennis O Mook-Kanamori Department of Clinical Epidemiology. Leiden University Medical Center. Leiden, the Netherlands/ Department of Public Health and Primary Care. Leiden University Medical Center. Leiden, the Netherlands Morten Salling Olesen Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Sandosh Padmanabhan Institute of Cardiovascular and Medical Sciences. University of Glasgow. Glasgow, UK. Bruce M Psaty Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA/ Department of Epidemiology. University of Washington. Seattle, WA, USA/ Department of Health Systems and Population Health. University of Washington. Seattte, WA, USA. Cristian Pattaro Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy. Antonio Luiz P Ribeiro 81 82, Jerome I Rotter 6 48 83, Bruno H Stricker Department of Epidemiology. Erasmus Medical Center. Rotterdam, the Netherlands. Pim van der Harst University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, the Netherlands/Department of Cardiology. Heart and Lung Division. University Medical Center Utrecht. Utrecht, the Netherlands. Cornelia M van Duijn Nuffield Department of Population Health. University of Oxford. Oxford, UK/Department of Epidemiology. Erasmus MC University Medical Center. Rotterdam, the Netherlands. Niek Verweij University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, the Netherlands James G Wilson Department of Physiology and Biophysics. University of Mississippi Medical Center.Jackson, MS, USA/Department of Cardiology. Beth Israel Deaconess Medical Center. Boston, MA, USA. Michele Orini Barts Heart Centre. St Bartholomew's Hospital. Barts Health NHS trust. London, UK/ Institute of Cardiovascular Sciences. University of College London. London, UK. Philippe Charron Sorbonne Universite. Research Unit on Cardiovascular Disorders. Metabolism and Nutrition. Team Genomics & Pathophysiology of Cardiovascular Disease. Paris, France/ICAN Institute for Cardiometabolism and Nutrition. Paris, France/ APHP. Cardiology Department. Pitié-Salpêtrière Hospital. Paris, France/APHP. Département de Génétique. Centre de Référence Maladies Cardiaques Héréditaires. Pitié-Salpêtrière Hospital. Paris, France. Hugh Watkins Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/ Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Charles Kooperberg Public Health Sciences Division. Fred Hutchinson Cancer Center. Seattle, WA, USA. Henry J Lin Institute for Translational Genomics and Population Sciences. Torrance, CA, USA./The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA/ Department of Pediatrics. Harbor-UCLA Medical Center. Torrance, CA, USA/ Department of Pediatrics. David Geffen School of Medicine at UCLA. Los Angeles, CA, USA. James F Wilson Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland/ MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland. Jørgen K Kanters Laboratory of Experimental Cardiology. Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Nona Sotoodehnia Cardiovascular Health Research Unit. Division of Cardiology. Department of Medicine. University of Washington. Seattle, WA, USA. Borbala Mifsud William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/ Genomics and Translational Biomedicine. College of Health and Life Sciences. Hamad Bin Khalifa University. Doha, Qatar. Pier D Lambiase Barts Heart Centre. St Bartholomew's Hospital. Barts Health NHS trust. London, UK/Institute of Cardiovascular Sciences. University of College London. London, UK. Larisa G Tereshchenko Department of Quantitative Health Sciences. Lerner Research Institute. Cleveland Clinic. Cleveland, OH, USA/Department of Medicine. Cardiovascular Division. Johns Hopkins University. School of Medicine. Baltimore, MD, USA. Patricia B Munroe William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK.
id CRUZ_f1d585ab44f87c4fde63b0d7975dab17
oai_identifier_str oai:www.arca.fiocruz.br:icict/58224
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Young, William JCosta, Maria Fernanda Furtado LimaDiversos autores2023-05-09T17:22:47Z2023-05-09T17:22:47Z2023YOUNG, William J et al. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Nature Communications, v. 14, n. 1, 1411, 2023. doi: 10.1038/s41467-023-36997-w.2041-1723https://www.arca.fiocruz.br/handle/icict/58224Jeffrey Haessler Public Health Sciences Division. Fred Hutchinson Cancer Center. Seattle, WA, USA. Jan-Walter Benjamins University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, the Netherlands. Linda Repetto Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland. Jie Yao Institute for Translational Genomics and Population Sciences. Torrance, CA, USA./The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA. Aaron Isaacs Dept. of Physiology. Cardiovascular Research Institute Maastricht. Maastricht University, Maastricht. the Netherlands/Center for Systems Biology. Maastricht University. Maastricht, the Netherlands. Andrew R Harper Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Julia Ramirez William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK /Institute of Cardiovascular Sciences. University of College London. London, UK/Aragon Institute of Engineering Research. University of Zaragoza. Zaragoza, Spain/Center of Biomedical Research Network. Bioengineering, Biomaterials and Nanomedicine. Zaragoza, Spain. Sophie Garnier Sorbonne Universite. Research Unit on Cardiovascular Disorders. Metabolism and Nutrition. Team Genomics & Pathophysiology of Cardiovascular Disease. Paris, Franc/ICAN Institute for Cardiometabolism and Nutrition. Paris, France. Stefan van Duijvenboden William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/ Institute of Cardiovascular Sciences. University of College London. London, UK. Antoine R Baldassari Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Maria Pina Concas Institute for Maternal and Child Health - IRCCS "Burlo Garofolo". Trieste, Italy. ThuyVy Duong McKusick-Nathans Institute. Department of Genetic Medicine. Johns Hopkins University School of Medicine. Baltimore, MD, USA. Luisa Foco Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy. Jonas L Isaksen Laboratory of Experimental Cardiology. Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Hao Mei Department of Data Science. University of Mississippi Medical Center. Jackson, MS, USA. Raymond Noordam Department of Internal Medicine. section of Gerontology and Geriatrics. Leiden University Medical Center. Leiden, the Netherlands. Casia Nursyifa Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Anne Richmond MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland. Meddly L Santolalla Department of Genetics, Ecology and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Emerge, Emerging Diseases and Climate Change Research Unit. School of Public Health and Administration. Universidad Peruana Cayetano Heredia. Lima, Peru. Colleen M Sitlani Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Negin Soroush Department of Epidemiology. Erasmus Medical Center. Rotterdam, the Netherlands. Sébastien Thériault Population Health Research Institute. McMaster University. Hamilton, ON, Canada/Department of Molecular Biology. Medical Biochemistry and Pathology. Université Laval, Quebec. QC, Canada. Stella Trompet Department of Internal Medicine. section of Gerontology and Geriatrics. Leiden University Medical Center. Leiden, the Netherlands/Department of Cardiology. Leiden University Medical Center. Leiden, the Netherlands. Stefanie Aeschbacher Julius Global Health. University Utrecht Medical Center. Utrecht, the Netherlands. Fariba Ahmadizar 27 32, Alvaro Alonso Department of Epidemiology. Rollins School of Public Health. Emory University. Atlanta, GA, USA. Jennifer A Brody Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Archie Campbell Usher Institute. University of Edinburgh. Edinburgh, UK/Health Data Research UK. University of Edinburgh., Edinburgh, UK/Centre for Genomic and Experimental Medicine. Institute of Genéticos and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK. Adolfo Correa Departments of Medicine. Pediatrics and Population Health Science. University of Mississippi Medical Center. Jackson, MS, USA. Dawood Darbar Department of Medicine. University of Illinois at Chicago. Chicago, IL, USA. Antonio De Luca Cardiothoracovascular Department. Division of Cardiology. Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste. Trieste, Italy. Jean-François Deleuze Université Paris-Saclay. Centre National de Recherche en Génomique Humaine. Evry, France/Laboratory of Excellence GENMED. Paris, France/Centre d'Etude du Polymorphisme Humain. Fondation Jean Dausset. Paris, France. Christina Ellervik Department of Data and Data Support, Region Zealand, 4180, Sorø, Denmark/Department of Clinical Medicine. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark/Department of Laboratory Medicine. Boston Children's Hospital. Harvard Medical School. Boston, MA, USA. Christian Fuchsberger Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy/Department of Biostatistics. University of Michigan School of Public Health, Ann Arbor, MI, USA/ Center for Statistical Genetics, University of Michigan School of Public Health. Ann Arbor, MI, USA. Anuj Goel Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Christopher Grace Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Xiuqing Guo Institute for Translational Genomics and Population Sciences. Torrance, CA, USA./The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics. Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics. David Geffen School of Medicine at UCLA. Los Angeles, CA, USA. Torben Hansen Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Susan R Heckbert Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA/Department of Epidemiology. University of Washington. Seattle, WA, USA. Rebecca D Jackson Center for Clinical and Translational Science. Ohio State Medical Center. Columbus, OH, USA. Jan A Kors Department of Medical Informatics. Erasmus University Medical Center. Rotterdam, the Netherlands. Allan Linneberg Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital. København, Denmark/Department of Clinical Medicine. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Peter W Macfarlane Institute of Health and Wellbeing. School of Health and Wellbeing. College of Medical, Veterinary and Life Sciences. University of Glasgow, Glasgow, UK. Alanna C Morrison Human Genetics Center. Department of Epidemiology, Human Genetics, and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston. Houston, TX, USA. Pau Navarro MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland David J Porteous Centre for Genomic and Experimental Medicine. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK/Centre for Cognitive Ageing and Cognitive Epidemiology. University of Edinburgh. Edinburgh, UK. Peter P Pramstaller Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy/Department of Neurology. University of Lübeck. Lübeck, Germany. Alexander P Reiner Department of Epidemiology. University of Washington. Seattle, WA, USA/ Fred Hutchinson Cancer Center. University of Washington. Seattle, WA, USA. Lorenz Risch Labormedizinisches zentrum Dr. Risch. Vaduz, Liechtenstein/Faculty of Medical Sciences. Private University in the Principality of Liechtenstein. Triesen, Liechtenstein/Center of Laboratory Medicine. University Institute of Clinical Chemistry. University of Bern, Inselspital. Bern, Switzerland. Ulrich Schotten Dept. of Physiology. Cardiovascular Research Institute Maastricht. Maastricht University, Maastricht. the Netherlands. Xia Shen Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland/Department of Medical Epidemiology and Biostatistics. Karolinska Institutet. Stockholm, Sweden/Greater Bay Area Institute of Precision Medicine. Fudan University. Nansha District, Guangzhou, China. Gianfranco Sinagra Cardiothoracovascular Department. Division of Cardiology. Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste. Trieste, Italy. Elsayed Z Soliman Epidemiological Cardiology Research Center. Wake Forest School of Medicine. Winston Salem, NC, USA. Monika Stoll Maastricht Center for Systems Biology. Maastricht University. Maastricht, the Netherlands/Dept. of Biochemistry. Cardiovascular Research Institute Maastricht. Maastricht University. Maastricht, the Netherlands/Institute of Human Genetics, Genetic Epidemiology, University of Muenster, Muenster, Germany. Eduardo Tarazona-Santos Department of Genetics, Ecology and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. Andrew Tinker William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK. Katerina Trajanoska Department of Internal Medicine. Erasmus Medical Center. Rotterdam, the Netherlands. Eric Villard Sorbonne Universite. Research Unit on Cardiovascular Disorders. Metabolism and Nutrition. Team Genomics & Pathophysiology of Cardiovascular Disease. Paris, France/ICAN Institute for Cardiometabolism and Nutrition. Paris, France. Helen R Warren William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK. Eric A Whitsel Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA/ Department of Medicine. School of Medicine. University of North Carolina. Chapel Hill, NC, USA. Kerri L Wiggins Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Dan E Arking McKusick-Nathans Institute. Department of Genetic Medicine. Johns Hopkins University School of Medicine. Baltimore, MD, USA. Christy L Avery Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. David Conen Population Health Research Institute. McMaster University. Hamilton, ON, Canada. Giorgia Girotto Institute for Maternal and Child Health - IRCCS "Burlo Garofolo". Trieste, Italy/ Department of Medical. Surgery and Health Sciences. University of Trieste. Trieste, Italy. Niels Grarup Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Caroline Hayward MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK. J Wouter Jukema Department of Cardiology. Leiden University Medical Center. Leiden, the Netherlands/ Netherlands Heart Institute. Utrecht, the Netherlands/Durrer Center for Cardiovascular Research. Amsterdam, the Netherlands. Dennis O Mook-Kanamori Department of Clinical Epidemiology. Leiden University Medical Center. Leiden, the Netherlands/ Department of Public Health and Primary Care. Leiden University Medical Center. Leiden, the Netherlands Morten Salling Olesen Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Sandosh Padmanabhan Institute of Cardiovascular and Medical Sciences. University of Glasgow. Glasgow, UK. Bruce M Psaty Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA/ Department of Epidemiology. University of Washington. Seattle, WA, USA/ Department of Health Systems and Population Health. University of Washington. Seattte, WA, USA. Cristian Pattaro Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy. Antonio Luiz P Ribeiro 81 82, Jerome I Rotter 6 48 83, Bruno H Stricker Department of Epidemiology. Erasmus Medical Center. Rotterdam, the Netherlands. Pim van der Harst University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, the Netherlands/Department of Cardiology. Heart and Lung Division. University Medical Center Utrecht. Utrecht, the Netherlands. Cornelia M van Duijn Nuffield Department of Population Health. University of Oxford. Oxford, UK/Department of Epidemiology. Erasmus MC University Medical Center. Rotterdam, the Netherlands. Niek Verweij University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, the Netherlands James G Wilson Department of Physiology and Biophysics. University of Mississippi Medical Center.Jackson, MS, USA/Department of Cardiology. Beth Israel Deaconess Medical Center. Boston, MA, USA. Michele Orini Barts Heart Centre. St Bartholomew's Hospital. Barts Health NHS trust. London, UK/ Institute of Cardiovascular Sciences. University of College London. London, UK. Philippe Charron Sorbonne Universite. Research Unit on Cardiovascular Disorders. Metabolism and Nutrition. Team Genomics & Pathophysiology of Cardiovascular Disease. Paris, France/ICAN Institute for Cardiometabolism and Nutrition. Paris, France/ APHP. Cardiology Department. Pitié-Salpêtrière Hospital. Paris, France/APHP. Département de Génétique. Centre de Référence Maladies Cardiaques Héréditaires. Pitié-Salpêtrière Hospital. Paris, France. Hugh Watkins Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/ Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Charles Kooperberg Public Health Sciences Division. Fred Hutchinson Cancer Center. Seattle, WA, USA. Henry J Lin Institute for Translational Genomics and Population Sciences. Torrance, CA, USA./The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA/ Department of Pediatrics. Harbor-UCLA Medical Center. Torrance, CA, USA/ Department of Pediatrics. David Geffen School of Medicine at UCLA. Los Angeles, CA, USA. James F Wilson Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland/ MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland. Jørgen K Kanters Laboratory of Experimental Cardiology. Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Nona Sotoodehnia Cardiovascular Health Research Unit. Division of Cardiology. Department of Medicine. University of Washington. Seattle, WA, USA. Borbala Mifsud William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/ Genomics and Translational Biomedicine. College of Health and Life Sciences. Hamad Bin Khalifa University. Doha, Qatar. Pier D Lambiase Barts Heart Centre. St Bartholomew's Hospital. Barts Health NHS trust. London, UK/Institute of Cardiovascular Sciences. University of College London. London, UK. Larisa G Tereshchenko Department of Quantitative Health Sciences. Lerner Research Institute. Cleveland Clinic. Cleveland, OH, USA/Department of Medicine. Cardiovascular Division. Johns Hopkins University. School of Medicine. Baltimore, MD, USA. Patricia B Munroe William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK.William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/Heart Centre. St Bartholomew's Hospital. Barts Health NHS trust. London, UK.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.ver campo notasThe 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.engNature Pub. GroupGenetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58224/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGenetic architecture of spatial electrical biomarkers.pdfGenetic architecture of spatial electrical biomarkers.pdfapplication/pdf3263827https://www.arca.fiocruz.br/bitstream/icict/58224/2/Genetic%20architecture%20of%20spatial%20electrical%20biomarkers.pdf2df25f9812b295f62152cf2607aba769MD52icict/582242023-05-09 14:22:48.527oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-09T17:22:48Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
title Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
spellingShingle Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
Young, William J
title_short Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
title_full Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
title_fullStr Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
title_full_unstemmed Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
title_sort Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
author Young, William J
author_facet Young, William J
Costa, Maria Fernanda Furtado Lima
Diversos autores
author_role author
author2 Costa, Maria Fernanda Furtado Lima
Diversos autores
author2_role author
author
dc.contributor.author.fl_str_mv Young, William J
Costa, Maria Fernanda Furtado Lima
Diversos autores
description Jeffrey Haessler Public Health Sciences Division. Fred Hutchinson Cancer Center. Seattle, WA, USA. Jan-Walter Benjamins University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, the Netherlands. Linda Repetto Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland. Jie Yao Institute for Translational Genomics and Population Sciences. Torrance, CA, USA./The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA. Aaron Isaacs Dept. of Physiology. Cardiovascular Research Institute Maastricht. Maastricht University, Maastricht. the Netherlands/Center for Systems Biology. Maastricht University. Maastricht, the Netherlands. Andrew R Harper Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Julia Ramirez William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK /Institute of Cardiovascular Sciences. University of College London. London, UK/Aragon Institute of Engineering Research. University of Zaragoza. Zaragoza, Spain/Center of Biomedical Research Network. Bioengineering, Biomaterials and Nanomedicine. Zaragoza, Spain. Sophie Garnier Sorbonne Universite. Research Unit on Cardiovascular Disorders. Metabolism and Nutrition. Team Genomics & Pathophysiology of Cardiovascular Disease. Paris, Franc/ICAN Institute for Cardiometabolism and Nutrition. Paris, France. Stefan van Duijvenboden William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/ Institute of Cardiovascular Sciences. University of College London. London, UK. Antoine R Baldassari Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Maria Pina Concas Institute for Maternal and Child Health - IRCCS "Burlo Garofolo". Trieste, Italy. ThuyVy Duong McKusick-Nathans Institute. Department of Genetic Medicine. Johns Hopkins University School of Medicine. Baltimore, MD, USA. Luisa Foco Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy. Jonas L Isaksen Laboratory of Experimental Cardiology. Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Hao Mei Department of Data Science. University of Mississippi Medical Center. Jackson, MS, USA. Raymond Noordam Department of Internal Medicine. section of Gerontology and Geriatrics. Leiden University Medical Center. Leiden, the Netherlands. Casia Nursyifa Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Anne Richmond MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland. Meddly L Santolalla Department of Genetics, Ecology and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Emerge, Emerging Diseases and Climate Change Research Unit. School of Public Health and Administration. Universidad Peruana Cayetano Heredia. Lima, Peru. Colleen M Sitlani Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Negin Soroush Department of Epidemiology. Erasmus Medical Center. Rotterdam, the Netherlands. Sébastien Thériault Population Health Research Institute. McMaster University. Hamilton, ON, Canada/Department of Molecular Biology. Medical Biochemistry and Pathology. Université Laval, Quebec. QC, Canada. Stella Trompet Department of Internal Medicine. section of Gerontology and Geriatrics. Leiden University Medical Center. Leiden, the Netherlands/Department of Cardiology. Leiden University Medical Center. Leiden, the Netherlands. Stefanie Aeschbacher Julius Global Health. University Utrecht Medical Center. Utrecht, the Netherlands. Fariba Ahmadizar 27 32, Alvaro Alonso Department of Epidemiology. Rollins School of Public Health. Emory University. Atlanta, GA, USA. Jennifer A Brody Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Archie Campbell Usher Institute. University of Edinburgh. Edinburgh, UK/Health Data Research UK. University of Edinburgh., Edinburgh, UK/Centre for Genomic and Experimental Medicine. Institute of Genéticos and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK. Adolfo Correa Departments of Medicine. Pediatrics and Population Health Science. University of Mississippi Medical Center. Jackson, MS, USA. Dawood Darbar Department of Medicine. University of Illinois at Chicago. Chicago, IL, USA. Antonio De Luca Cardiothoracovascular Department. Division of Cardiology. Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste. Trieste, Italy. Jean-François Deleuze Université Paris-Saclay. Centre National de Recherche en Génomique Humaine. Evry, France/Laboratory of Excellence GENMED. Paris, France/Centre d'Etude du Polymorphisme Humain. Fondation Jean Dausset. Paris, France. Christina Ellervik Department of Data and Data Support, Region Zealand, 4180, Sorø, Denmark/Department of Clinical Medicine. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark/Department of Laboratory Medicine. Boston Children's Hospital. Harvard Medical School. Boston, MA, USA. Christian Fuchsberger Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy/Department of Biostatistics. University of Michigan School of Public Health, Ann Arbor, MI, USA/ Center for Statistical Genetics, University of Michigan School of Public Health. Ann Arbor, MI, USA. Anuj Goel Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Christopher Grace Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Xiuqing Guo Institute for Translational Genomics and Population Sciences. Torrance, CA, USA./The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics. Harbor-UCLA Medical Center. Torrance, CA, USA/Department of Pediatrics. David Geffen School of Medicine at UCLA. Los Angeles, CA, USA. Torben Hansen Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Susan R Heckbert Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA/Department of Epidemiology. University of Washington. Seattle, WA, USA. Rebecca D Jackson Center for Clinical and Translational Science. Ohio State Medical Center. Columbus, OH, USA. Jan A Kors Department of Medical Informatics. Erasmus University Medical Center. Rotterdam, the Netherlands. Allan Linneberg Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital. København, Denmark/Department of Clinical Medicine. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Peter W Macfarlane Institute of Health and Wellbeing. School of Health and Wellbeing. College of Medical, Veterinary and Life Sciences. University of Glasgow, Glasgow, UK. Alanna C Morrison Human Genetics Center. Department of Epidemiology, Human Genetics, and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston. Houston, TX, USA. Pau Navarro MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland David J Porteous Centre for Genomic and Experimental Medicine. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK/Centre for Cognitive Ageing and Cognitive Epidemiology. University of Edinburgh. Edinburgh, UK. Peter P Pramstaller Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy/Department of Neurology. University of Lübeck. Lübeck, Germany. Alexander P Reiner Department of Epidemiology. University of Washington. Seattle, WA, USA/ Fred Hutchinson Cancer Center. University of Washington. Seattle, WA, USA. Lorenz Risch Labormedizinisches zentrum Dr. Risch. Vaduz, Liechtenstein/Faculty of Medical Sciences. Private University in the Principality of Liechtenstein. Triesen, Liechtenstein/Center of Laboratory Medicine. University Institute of Clinical Chemistry. University of Bern, Inselspital. Bern, Switzerland. Ulrich Schotten Dept. of Physiology. Cardiovascular Research Institute Maastricht. Maastricht University, Maastricht. the Netherlands. Xia Shen Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland/Department of Medical Epidemiology and Biostatistics. Karolinska Institutet. Stockholm, Sweden/Greater Bay Area Institute of Precision Medicine. Fudan University. Nansha District, Guangzhou, China. Gianfranco Sinagra Cardiothoracovascular Department. Division of Cardiology. Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste. Trieste, Italy. Elsayed Z Soliman Epidemiological Cardiology Research Center. Wake Forest School of Medicine. Winston Salem, NC, USA. Monika Stoll Maastricht Center for Systems Biology. Maastricht University. Maastricht, the Netherlands/Dept. of Biochemistry. Cardiovascular Research Institute Maastricht. Maastricht University. Maastricht, the Netherlands/Institute of Human Genetics, Genetic Epidemiology, University of Muenster, Muenster, Germany. Eduardo Tarazona-Santos Department of Genetics, Ecology and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. Andrew Tinker William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK. Katerina Trajanoska Department of Internal Medicine. Erasmus Medical Center. Rotterdam, the Netherlands. Eric Villard Sorbonne Universite. Research Unit on Cardiovascular Disorders. Metabolism and Nutrition. Team Genomics & Pathophysiology of Cardiovascular Disease. Paris, France/ICAN Institute for Cardiometabolism and Nutrition. Paris, France. Helen R Warren William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK. Eric A Whitsel Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA/ Department of Medicine. School of Medicine. University of North Carolina. Chapel Hill, NC, USA. Kerri L Wiggins Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA. Dan E Arking McKusick-Nathans Institute. Department of Genetic Medicine. Johns Hopkins University School of Medicine. Baltimore, MD, USA. Christy L Avery Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. David Conen Population Health Research Institute. McMaster University. Hamilton, ON, Canada. Giorgia Girotto Institute for Maternal and Child Health - IRCCS "Burlo Garofolo". Trieste, Italy/ Department of Medical. Surgery and Health Sciences. University of Trieste. Trieste, Italy. Niels Grarup Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark. Caroline Hayward MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital. Edinburgh, UK. J Wouter Jukema Department of Cardiology. Leiden University Medical Center. Leiden, the Netherlands/ Netherlands Heart Institute. Utrecht, the Netherlands/Durrer Center for Cardiovascular Research. Amsterdam, the Netherlands. Dennis O Mook-Kanamori Department of Clinical Epidemiology. Leiden University Medical Center. Leiden, the Netherlands/ Department of Public Health and Primary Care. Leiden University Medical Center. Leiden, the Netherlands Morten Salling Olesen Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Sandosh Padmanabhan Institute of Cardiovascular and Medical Sciences. University of Glasgow. Glasgow, UK. Bruce M Psaty Cardiovascular Health Research Unit. Department of Medicine. University of Washington. Seattle, WA, USA/ Department of Epidemiology. University of Washington. Seattle, WA, USA/ Department of Health Systems and Population Health. University of Washington. Seattte, WA, USA. Cristian Pattaro Eurac Research. Institute for Biomedicine. University of Lübeck. Bolzano, Italy. Antonio Luiz P Ribeiro 81 82, Jerome I Rotter 6 48 83, Bruno H Stricker Department of Epidemiology. Erasmus Medical Center. Rotterdam, the Netherlands. Pim van der Harst University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, the Netherlands/Department of Cardiology. Heart and Lung Division. University Medical Center Utrecht. Utrecht, the Netherlands. Cornelia M van Duijn Nuffield Department of Population Health. University of Oxford. Oxford, UK/Department of Epidemiology. Erasmus MC University Medical Center. Rotterdam, the Netherlands. Niek Verweij University of Groningen. University Medical Center Groningen. Department of Cardiology. Groningen, the Netherlands James G Wilson Department of Physiology and Biophysics. University of Mississippi Medical Center.Jackson, MS, USA/Department of Cardiology. Beth Israel Deaconess Medical Center. Boston, MA, USA. Michele Orini Barts Heart Centre. St Bartholomew's Hospital. Barts Health NHS trust. London, UK/ Institute of Cardiovascular Sciences. University of College London. London, UK. Philippe Charron Sorbonne Universite. Research Unit on Cardiovascular Disorders. Metabolism and Nutrition. Team Genomics & Pathophysiology of Cardiovascular Disease. Paris, France/ICAN Institute for Cardiometabolism and Nutrition. Paris, France/ APHP. Cardiology Department. Pitié-Salpêtrière Hospital. Paris, France/APHP. Département de Génétique. Centre de Référence Maladies Cardiaques Héréditaires. Pitié-Salpêtrière Hospital. Paris, France. Hugh Watkins Radcliffe Department of Medicine. University of Oxford. Division of Cardiovascular Medicine. John Radcliffe Hospital. Oxford, UK/ Wellcome Centre for Human Genetics. Roosevelt Drive, Oxford, UK. Charles Kooperberg Public Health Sciences Division. Fred Hutchinson Cancer Center. Seattle, WA, USA. Henry J Lin Institute for Translational Genomics and Population Sciences. Torrance, CA, USA./The Lundquist Institute at Harbor-UCLA Medical Center. Torrance, CA, USA/ Department of Pediatrics. Harbor-UCLA Medical Center. Torrance, CA, USA/ Department of Pediatrics. David Geffen School of Medicine at UCLA. Los Angeles, CA, USA. James F Wilson Centre for Global Health Research. Usher Institute. University of Edinburgh. Edinburgh, Scotland/ MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Edinburgh, Scotland. Jørgen K Kanters Laboratory of Experimental Cardiology. Department of Biomedical Sciences. University of Copenhagen. Copenhagen, Denmark. Nona Sotoodehnia Cardiovascular Health Research Unit. Division of Cardiology. Department of Medicine. University of Washington. Seattle, WA, USA. Borbala Mifsud William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/ Genomics and Translational Biomedicine. College of Health and Life Sciences. Hamad Bin Khalifa University. Doha, Qatar. Pier D Lambiase Barts Heart Centre. St Bartholomew's Hospital. Barts Health NHS trust. London, UK/Institute of Cardiovascular Sciences. University of College London. London, UK. Larisa G Tereshchenko Department of Quantitative Health Sciences. Lerner Research Institute. Cleveland Clinic. Cleveland, OH, USA/Department of Medicine. Cardiovascular Division. Johns Hopkins University. School of Medicine. Baltimore, MD, USA. Patricia B Munroe William Harvey Research Institute. Clinical Pharmacology. Queen Mary University of London. London, UK/NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London. London, UK.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-09T17:22:47Z
dc.date.available.fl_str_mv 2023-05-09T17:22:47Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv YOUNG, William J et al. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Nature Communications, v. 14, n. 1, 1411, 2023. doi: 10.1038/s41467-023-36997-w.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58224
dc.identifier.issn.en_US.fl_str_mv 2041-1723
identifier_str_mv YOUNG, William J et al. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Nature Communications, v. 14, n. 1, 1411, 2023. doi: 10.1038/s41467-023-36997-w.
2041-1723
url https://www.arca.fiocruz.br/handle/icict/58224
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Pub. Group
publisher.none.fl_str_mv Nature Pub. Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58224/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58224/2/Genetic%20architecture%20of%20spatial%20electrical%20biomarkers.pdf
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
2df25f9812b295f62152cf2607aba769
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324843401183232