Endothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia

Detalhes bibliográficos
Autor(a) principal: Vilas-Boas, Wendell
Data de Publicação: 2016
Outros Autores: Figueiredo, Camylla V. B., Pitanga, Thassila Nogueira, Carvalho, Magda Oliveira Seixas, Santiago, Rayra P., Santana, Sânzio Silva, Guarda, Caroline Conceição da, Zanette, Angela Maria Dias, Cerqueira, Bruno Antonio Veloso, Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17795
Resumo: We thank the patients for their participation because without them, this study would not have been conducted.
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spelling Vilas-Boas, WendellFigueiredo, Camylla V. B.Pitanga, Thassila NogueiraCarvalho, Magda Oliveira SeixasSantiago, Rayra P.Santana, Sânzio SilvaGuarda, Caroline Conceição daZanette, Angela Maria DiasCerqueira, Bruno Antonio VelosoGonçalves, Marilda de Souza2017-02-13T12:20:03Z2017-02-13T12:20:03Z2016VILAS-BOAS, W. et al. Endothelial nitric oxide synthase (−786T.C) and endothelin-1 (5665G.T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia. Gene Regulation and Systems Biology, n.10, p. 67-72, 2016.1177-6250https://www.arca.fiocruz.br/handle/icict/1779510.4137/GRSB.S38276We thank the patients for their participation because without them, this study would not have been conducted.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia da Bahia, Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade do Estado da Bahia, Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Analises Clínicas e Toxicologicas. Salvador, BA, Brasil.Sickle cell anemia (SCA) patients have vascular complications, and polymorphisms in endothelin-1 (ET-1) and endothelial nitric oxide synthase (eNOS) genes were associated with ET-1 and nitric oxide disturbance. We investigate the association of ET-1 5665G>T and eNOS -786T>C polymorphisms with soluble adhesion molecules (sVCAM-1 and sICAM-1), biochemical markers, and medical history. We studied 101 SCA patients; carriers of eNOS minor allele (C) had the highest levels of sVCAM-1, and carriers of ET-1 minor allele had more occurrence of acute chest syndrome (ACS). The multivariate analysis suggested the influence of the ET-1 gene on ACS outcome and an association of the eNOS gene with upper respiratory tract infection. We suggest that eNOS and ET-1 gene polymorphisms can influence SCA pathophysiology and that eNOS variant in SCA patients might be important to nitric oxide activity and vascular alteration. We found an association of the ET-1 minor allele in ACS, showing the importance of genetic screening in SCA.engLibertas Academica JournalsAnemia FalciformeeNOSSickle cell anemiaeNOSEntothelin-1Gene polymorphismsAnemia FalciformeEndothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17795/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Wendell_Vilas-Boas_etal_CPqGM_2016 .pdfve_Wendell_Vilas-Boas_etal_CPqGM_2016 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dc.title.pt_BR.fl_str_mv Endothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia
title Endothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia
spellingShingle Endothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia
Vilas-Boas, Wendell
Anemia Falciforme
eNOS
Sickle cell anemia
eNOS
Entothelin-1
Gene polymorphisms
Anemia Falciforme
title_short Endothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia
title_full Endothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia
title_fullStr Endothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia
title_full_unstemmed Endothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia
title_sort Endothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia
author Vilas-Boas, Wendell
author_facet Vilas-Boas, Wendell
Figueiredo, Camylla V. B.
Pitanga, Thassila Nogueira
Carvalho, Magda Oliveira Seixas
Santiago, Rayra P.
Santana, Sânzio Silva
Guarda, Caroline Conceição da
Zanette, Angela Maria Dias
Cerqueira, Bruno Antonio Veloso
Gonçalves, Marilda de Souza
author_role author
author2 Figueiredo, Camylla V. B.
Pitanga, Thassila Nogueira
Carvalho, Magda Oliveira Seixas
Santiago, Rayra P.
Santana, Sânzio Silva
Guarda, Caroline Conceição da
Zanette, Angela Maria Dias
Cerqueira, Bruno Antonio Veloso
Gonçalves, Marilda de Souza
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vilas-Boas, Wendell
Figueiredo, Camylla V. B.
Pitanga, Thassila Nogueira
Carvalho, Magda Oliveira Seixas
Santiago, Rayra P.
Santana, Sânzio Silva
Guarda, Caroline Conceição da
Zanette, Angela Maria Dias
Cerqueira, Bruno Antonio Veloso
Gonçalves, Marilda de Souza
dc.subject.other.pt_BR.fl_str_mv Anemia Falciforme
eNOS
topic Anemia Falciforme
eNOS
Sickle cell anemia
eNOS
Entothelin-1
Gene polymorphisms
Anemia Falciforme
dc.subject.en.pt_BR.fl_str_mv Sickle cell anemia
eNOS
Entothelin-1
Gene polymorphisms
dc.subject.decs.pt_BR.fl_str_mv Anemia Falciforme
description We thank the patients for their participation because without them, this study would not have been conducted.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-02-13T12:20:03Z
dc.date.available.fl_str_mv 2017-02-13T12:20:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VILAS-BOAS, W. et al. Endothelial nitric oxide synthase (−786T.C) and endothelin-1 (5665G.T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia. Gene Regulation and Systems Biology, n.10, p. 67-72, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17795
dc.identifier.issn.pt_BR.fl_str_mv 1177-6250
dc.identifier.doi.pt_BR.fl_str_mv 10.4137/GRSB.S38276
identifier_str_mv VILAS-BOAS, W. et al. Endothelial nitric oxide synthase (−786T.C) and endothelin-1 (5665G.T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia. Gene Regulation and Systems Biology, n.10, p. 67-72, 2016.
1177-6250
10.4137/GRSB.S38276
url https://www.arca.fiocruz.br/handle/icict/17795
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Libertas Academica Journals
publisher.none.fl_str_mv Libertas Academica Journals
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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