Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas

Detalhes bibliográficos
Autor(a) principal: Baptista, Barbara Oliveira
Data de Publicação: 2022
Outros Autores: Souza, Ana Beatriz Lopes de, Riccio, Evelyn Kety Pratt, Bianco-Junior, Cesare, Totino, Paulo Renato Rivas, Silva, João Hermínio Martins da, Theisen, Michael, Singh, Susheel Kumar, Amoah, Linda Eva, Ribeiro-Alves, Marcelo, Souza, Rodrigo Medeiros, Lima-Junior, Josué Costa, Daniel-Ribeiro, Cláudio Tadeu, Pratt-Riccio, Lilian Rose
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1186/s12936-021-04020-6
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51849
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.
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spelling Baptista, Barbara OliveiraSouza, Ana Beatriz Lopes deRiccio, Evelyn Kety PrattBianco-Junior, CesareTotino, Paulo Renato RivasSilva, João Hermínio Martins daTheisen, MichaelSingh, Susheel KumarAmoah, Linda EvaRibeiro-Alves, MarceloSouza, Rodrigo MedeirosLima-Junior, Josué CostaDaniel-Ribeiro, Cláudio TadeuPratt-Riccio, Lilian Rose2022-03-24T00:30:48Z2022-03-24T00:30:48Z2022BAPTISTA, Barbara Oliveira et al. Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas. Malaria journal, v. 21, n. 1, p. 1-16, 2022,1475-2875https://www.arca.fiocruz.br/handle/icict/5184910.1186/s12936-021-04020-6engBMCNaturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Departamento de Bioinformática. Eusébio, CE, Brasil.University of Copenhagen and Department of Infectious Diseases. Copenhagen University Hospital. Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology. Rigshospitalet, Copenhagen, Denmark.University of Copenhagen and Department of Infectious Diseases. Copenhagen University Hospital. Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology. Rigshospitalet, Copenhagen, Denmark.University of Ghana. Noguchi Memorial Institute for Medical Research. Immunology Department. Accra, Ghana.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Universidade Federal do Acre. Laboratório de Doenças Infecciosas na Amazônia Ocidental. Rio Branco, AC, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Background: The GMZ2.6c malaria vaccine candidate is a multi-stage Plasmodium falciparum chimeric protein which contains a fragment of the sexual-stage Pfs48/45-6C protein genetically fused to GMZ2, a fusion protein of GLURP and MSP-3, that has been shown to be well tolerated, safe and immunogenic in clinical trials performed in a malaria-endemic area of Africa. However, there is no data available on the antigenicity or immunogenicity of GMZ2.6c in humans. Considering that circulating parasites can be genetically distinct in different malaria-endemic areas and that host genetic factors can influence the immune response to vaccine antigens, it is important to verify the antigenicity, immunogenicity and the possibility of associated protection in individuals living in malaria-endemic areas with different epidemiological scenarios. Herein, the profile of antibody response against GMZ2.6c and its components (MSP-3, GLURP and Pfs48/45) in residents of the Brazilian Amazon naturally exposed to malaria, in areas with different levels of transmission, was evaluated. Methods: This study was performed using serum samples from 352 individuals from Cruzeiro do Sul and Mâncio Lima, in the state of Acre, and Guajará, in the state of Amazonas. Specific IgG, IgM, IgA and IgE antibodies and IgG subclasses were detected by Enzyme-Linked Immunosorbent Assay. Results: The results showed that GMZ2.6c protein was widely recognized by naturally acquired antibodies from individuals of the Brazilian endemic areas with different levels of transmission. The higher prevalence of individuals with antibodies against GMZ2.6c when compared to its individual components may suggest an additive effect of GLURP, MSP-3, and Pfs48/45 when inserted in a same construct. Furthermore, naturally malaria-exposed individuals predominantly had IgG1 and IgG3 cytophilic anti-GMZ2.6c antibodies, an important fact considering that the acquisition of anti-malaria protective immunity results from a delicate balance between cytophilic/non-cytophilic antibodies. Interestingly, anti-GMZ2.6c antibodies seem to increase with exposure to malaria infection and may contribute to parasite immunity. Conclusions: The data showed that GMZ2.6c protein is widely recognized by naturally acquired antibodies from individuals living in malaria-endemic areas in Brazil and that these may contribute to parasite immunity. These data highlight the importance of GMZ2.6c as a candidate for an anti-malarial vaccine.AntibodiesGMZ2.6cImmune responseMalariaPlasmodium falciparumVaccineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/51849/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALNaturally_Marcelo_Alves_etal_INI_2022.pdfNaturally_Marcelo_Alves_etal_INI_2022.pdfapplication/pdf3023478https://www.arca.fiocruz.br/bitstream/icict/51849/2/Naturally_Marcelo_Alves_etal_INI_2022.pdf2a0365a42115ff1d8a8b606336e5c98aMD52icict/518492022-03-23 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dc.title.pt_BR.fl_str_mv Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas
title Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas
spellingShingle Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas
Baptista, Barbara Oliveira
Antibodies
GMZ2.6c
Immune response
Malaria
Plasmodium falciparum
Vaccine
title_short Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas
title_full Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas
title_fullStr Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas
title_full_unstemmed Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas
title_sort Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas
author Baptista, Barbara Oliveira
author_facet Baptista, Barbara Oliveira
Souza, Ana Beatriz Lopes de
Riccio, Evelyn Kety Pratt
Bianco-Junior, Cesare
Totino, Paulo Renato Rivas
Silva, João Hermínio Martins da
Theisen, Michael
Singh, Susheel Kumar
Amoah, Linda Eva
Ribeiro-Alves, Marcelo
Souza, Rodrigo Medeiros
Lima-Junior, Josué Costa
Daniel-Ribeiro, Cláudio Tadeu
Pratt-Riccio, Lilian Rose
author_role author
author2 Souza, Ana Beatriz Lopes de
Riccio, Evelyn Kety Pratt
Bianco-Junior, Cesare
Totino, Paulo Renato Rivas
Silva, João Hermínio Martins da
Theisen, Michael
Singh, Susheel Kumar
Amoah, Linda Eva
Ribeiro-Alves, Marcelo
Souza, Rodrigo Medeiros
Lima-Junior, Josué Costa
Daniel-Ribeiro, Cláudio Tadeu
Pratt-Riccio, Lilian Rose
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Baptista, Barbara Oliveira
Souza, Ana Beatriz Lopes de
Riccio, Evelyn Kety Pratt
Bianco-Junior, Cesare
Totino, Paulo Renato Rivas
Silva, João Hermínio Martins da
Theisen, Michael
Singh, Susheel Kumar
Amoah, Linda Eva
Ribeiro-Alves, Marcelo
Souza, Rodrigo Medeiros
Lima-Junior, Josué Costa
Daniel-Ribeiro, Cláudio Tadeu
Pratt-Riccio, Lilian Rose
dc.subject.en.pt_BR.fl_str_mv Antibodies
GMZ2.6c
Immune response
Malaria
Plasmodium falciparum
Vaccine
topic Antibodies
GMZ2.6c
Immune response
Malaria
Plasmodium falciparum
Vaccine
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-03-24T00:30:48Z
dc.date.available.fl_str_mv 2022-03-24T00:30:48Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BAPTISTA, Barbara Oliveira et al. Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas. Malaria journal, v. 21, n. 1, p. 1-16, 2022,
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51849
dc.identifier.issn.pt_BR.fl_str_mv 1475-2875
dc.identifier.doi.none.fl_str_mv 10.1186/s12936-021-04020-6
identifier_str_mv BAPTISTA, Barbara Oliveira et al. Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas. Malaria journal, v. 21, n. 1, p. 1-16, 2022,
1475-2875
10.1186/s12936-021-04020-6
url https://www.arca.fiocruz.br/handle/icict/51849
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51849/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51849/2/Naturally_Marcelo_Alves_etal_INI_2022.pdf
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