Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA

Detalhes bibliográficos
Autor(a) principal: Martins, Yuri Chaves
Data de Publicação: 2009
Outros Autores: Smith, Mary Jane, Machado, Marcelo Pelajo, Werneck, Guilherme Loureiro, Lenzi, Henrique Leonel, Daniel-Ribeiro, Cláudio Tadeu, Carvalho, Leonardo José de Moura
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/3738
Resumo: Acknowledgments To Marilene Damazio dos Santos and Luiz Carlos da Silva from the Leônidas Deane Animal House for caring mice. To Belmira Santos from the Fiocruz Animal House for providing the Swiss Webster and the CBA mice. To Rodrigo Mexes from the Service of Image Treatment and Production for treating the images.
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spelling Martins, Yuri ChavesSmith, Mary JaneMachado, Marcelo PelajoWerneck, Guilherme LoureiroLenzi, Henrique LeonelDaniel-Ribeiro, Cláudio TadeuCarvalho, Leonardo José de Moura2012-01-18T12:27:09Z2012-01-18T12:27:09Z2009MARTINS, Y. C. et al. Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA. International Journal of Experimental Pathology. v. 90, n. 2, p. 119-30. Apr. 2009.0959-9673https://www.arca.fiocruz.br/handle/icict/373810.1111/j.1365-2613.2008.00622.xAcknowledgments To Marilene Damazio dos Santos and Luiz Carlos da Silva from the Leônidas Deane Animal House for caring mice. To Belmira Santos from the Fiocruz Animal House for providing the Swiss Webster and the CBA mice. To Rodrigo Mexes from the Service of Image Treatment and Production for treating the images.This work was supported with funds of the Laboratory of Malaria Research and the Department of Pathology (POM) and of the Conselho Nacional de Desenvolvimento Tecnológico (CNPq) – Brazil. YCM and CTDR were receivers of fellowships from CNPq.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Plasmodium berghei ANKA (PbA) infection in susceptible inbred mouse strains is the most commonly used experimental model to study pathogenesis of cerebral malaria (CM). Indeed, many concepts on mechanisms related to this complication have arisen from works using this model. Although inbred strains present several advantages and are indicated for most studies, the use of outbred models can show unique usefulness in a number of approaches such as fine post-quantitative trait loci mapping and discovery of genes relevant to CM susceptibility or resistance, as well as pharmacological and vaccine studies. Here we describe the features of PbA infection and CM incidence, and characterize the associated multiorgan pathology in the outbred Swiss Webster mouse. This model showed a sizeable (62.7%) and reproducible incidence of CM demonstrated by clinical signs and histopathological changes in brain (microhaemorrhages, oedema and vessel plugging by mononuclear cells). Major pathological changes were also observed in lungs, liver, thymus and spleen, analogous to those observed in inbred strains. Parasitaemia levels were associated with the risk of CM development, the risk being significantly higher in mice showing higher values of parasitaemia on days 6–7 of infection. This outbred CM model is then suitable for genetic, vaccine and drug studies targeting this malaria complication.engWileyCharacterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKAinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCerebral MalariaHistopathologyMurine ModelPlasmodium berghei ANKASwiss WebsterMalária CerebralPatologiaPlasmodium bergheiinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCharacterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA..pdfCharacterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA..pdfapplication/pdf734470https://www.arca.fiocruz.br/bitstream/icict/3738/1/Characterization%20of%20cerebral%20malaria%20in%20the%20outbred%20Swiss%20Webster%20mouse%20infected%20by%20Plasmodium%20berghei%20ANKA..pdf52f96bccfed978a9d8dc73c61562fab9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3738/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTCharacterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA..pdf.txtCharacterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA..pdf.txtExtracted texttext/plain51235https://www.arca.fiocruz.br/bitstream/icict/3738/5/Characterization%20of%20cerebral%20malaria%20in%20the%20outbred%20Swiss%20Webster%20mouse%20infected%20by%20Plasmodium%20berghei%20ANKA..pdf.txt021fbe61b4169158752eba1be876168aMD55THUMBNAILCharacterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA..pdf.jpgCharacterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA..pdf.jpgGenerated Thumbnailimage/jpeg2157https://www.arca.fiocruz.br/bitstream/icict/3738/4/Characterization%20of%20cerebral%20malaria%20in%20the%20outbred%20Swiss%20Webster%20mouse%20infected%20by%20Plasmodium%20berghei%20ANKA..pdf.jpg992d5db62ffd9582964e9e12cbee327bMD54icict/37382022-06-24 12:19:41.069oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:19:41Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA
title Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA
spellingShingle Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA
Martins, Yuri Chaves
Cerebral Malaria
Histopathology
Murine Model
Plasmodium berghei ANKA
Swiss Webster
Malária Cerebral
Patologia
Plasmodium berghei
title_short Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA
title_full Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA
title_fullStr Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA
title_full_unstemmed Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA
title_sort Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA
author Martins, Yuri Chaves
author_facet Martins, Yuri Chaves
Smith, Mary Jane
Machado, Marcelo Pelajo
Werneck, Guilherme Loureiro
Lenzi, Henrique Leonel
Daniel-Ribeiro, Cláudio Tadeu
Carvalho, Leonardo José de Moura
author_role author
author2 Smith, Mary Jane
Machado, Marcelo Pelajo
Werneck, Guilherme Loureiro
Lenzi, Henrique Leonel
Daniel-Ribeiro, Cláudio Tadeu
Carvalho, Leonardo José de Moura
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Martins, Yuri Chaves
Smith, Mary Jane
Machado, Marcelo Pelajo
Werneck, Guilherme Loureiro
Lenzi, Henrique Leonel
Daniel-Ribeiro, Cláudio Tadeu
Carvalho, Leonardo José de Moura
dc.subject.en.pt_BR.fl_str_mv Cerebral Malaria
Histopathology
Murine Model
Plasmodium berghei ANKA
Swiss Webster
topic Cerebral Malaria
Histopathology
Murine Model
Plasmodium berghei ANKA
Swiss Webster
Malária Cerebral
Patologia
Plasmodium berghei
dc.subject.decs.pt_BR.fl_str_mv Malária Cerebral
Patologia
Plasmodium berghei
description Acknowledgments To Marilene Damazio dos Santos and Luiz Carlos da Silva from the Leônidas Deane Animal House for caring mice. To Belmira Santos from the Fiocruz Animal House for providing the Swiss Webster and the CBA mice. To Rodrigo Mexes from the Service of Image Treatment and Production for treating the images.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2012-01-18T12:27:09Z
dc.date.available.fl_str_mv 2012-01-18T12:27:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTINS, Y. C. et al. Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA. International Journal of Experimental Pathology. v. 90, n. 2, p. 119-30. Apr. 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/3738
dc.identifier.issn.none.fl_str_mv 0959-9673
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-2613.2008.00622.x
identifier_str_mv MARTINS, Y. C. et al. Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA. International Journal of Experimental Pathology. v. 90, n. 2, p. 119-30. Apr. 2009.
0959-9673
10.1111/j.1365-2613.2008.00622.x
url https://www.arca.fiocruz.br/handle/icict/3738
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
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