Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Ornelas, Alice Maria de Magalhães
Data de Publicação: 2019
Outros Autores: Xavier-de-Carvalho, Caroline, Alvarado-Arnez, Lucia Elena, Ribeiro-Alves, Marcelo, Rossi, Átila Duque, Tanuri, Amilcar, Aguiar, Renato Santana, Moraes, Milton Ozório, Cardoso, Cynthia Chester
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33446
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Ornelas, Alice Maria de MagalhãesXavier-de-Carvalho, CarolineAlvarado-Arnez, Lucia ElenaRibeiro-Alves, MarceloRossi, Átila DuqueTanuri, AmilcarAguiar, Renato SantanaMoraes, Milton OzórioCardoso, Cynthia Chester2019-06-10T19:34:37Z2019-06-10T19:34:37Z2019ORNELAS, Alice Maria de Magalhães et al. Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-7, 2019.0074-0276https://www.arca.fiocruz.br/handle/icict/3344610.1590/0074-027601900041678-8060engFiocruz/IOCAssociation between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST-AIDS. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro, Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Background: Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlinedthe association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies. Objectives: The aim of this study was to investigate the association between MBL2, CLEC5A, ITGB3 and CCR5 genes and dengue severity in children. Methods: A matched case-control study was conducted and 19 single nucleotide polymorphisms (SNPs) were investigated. Findings: No associations were observed in single SNP analysis. However, when MBL2 SNPs were combined in haplotypes, the allele rs7095891G/rs1800450C/ rs1800451C/rs4935047A/rs930509G/rs2120131G/rs2099902C was significantly associated to risk of severe dengue under α = 0.05 (aOR = 4.02; p = 0.02). A second haplotype carrying rs4935047G and rs7095891G alleles was also associated to risk (aOR = 1.91; p = 0.04). Main Conclusions: This is the first study to demonstrate the association between MBL2 haplotypes and dengue severity in Brazilians including adjustment for genetic ancestry. These results reinforce the role of mannose binding lectin in immune response to DENV.DenguePolymorphismsMBL2CCR5ITGB3CLEC5Ainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/33446/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALAssociation between MBL2_Marcelo_Ribeiro-Alves_INI_Lapclin-AIDS_2019.pdfAssociation between MBL2_Marcelo_Ribeiro-Alves_INI_Lapclin-AIDS_2019.pdfapplication/pdf384337https://www.arca.fiocruz.br/bitstream/icict/33446/2/Association%20between%20MBL2_Marcelo_Ribeiro-Alves_INI_Lapclin-AIDS_2019.pdfd9a3472dc639201787afe938b04a6ea6MD52TEXTAssociation between MBL2_Marcelo_Ribeiro-Alves_INI_Lapclin-AIDS_2019.pdf.txtAssociation between MBL2_Marcelo_Ribeiro-Alves_INI_Lapclin-AIDS_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
title Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
spellingShingle Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
Ornelas, Alice Maria de Magalhães
Dengue
Polymorphisms
MBL2
CCR5
ITGB3
CLEC5A
title_short Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
title_full Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
title_fullStr Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
title_full_unstemmed Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
title_sort Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
author Ornelas, Alice Maria de Magalhães
author_facet Ornelas, Alice Maria de Magalhães
Xavier-de-Carvalho, Caroline
Alvarado-Arnez, Lucia Elena
Ribeiro-Alves, Marcelo
Rossi, Átila Duque
Tanuri, Amilcar
Aguiar, Renato Santana
Moraes, Milton Ozório
Cardoso, Cynthia Chester
author_role author
author2 Xavier-de-Carvalho, Caroline
Alvarado-Arnez, Lucia Elena
Ribeiro-Alves, Marcelo
Rossi, Átila Duque
Tanuri, Amilcar
Aguiar, Renato Santana
Moraes, Milton Ozório
Cardoso, Cynthia Chester
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ornelas, Alice Maria de Magalhães
Xavier-de-Carvalho, Caroline
Alvarado-Arnez, Lucia Elena
Ribeiro-Alves, Marcelo
Rossi, Átila Duque
Tanuri, Amilcar
Aguiar, Renato Santana
Moraes, Milton Ozório
Cardoso, Cynthia Chester
dc.subject.en.pt_BR.fl_str_mv Dengue
Polymorphisms
MBL2
CCR5
ITGB3
CLEC5A
topic Dengue
Polymorphisms
MBL2
CCR5
ITGB3
CLEC5A
description Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-06-10T19:34:37Z
dc.date.available.fl_str_mv 2019-06-10T19:34:37Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ORNELAS, Alice Maria de Magalhães et al. Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-7, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33446
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760190004
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv ORNELAS, Alice Maria de Magalhães et al. Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-7, 2019.
0074-0276
10.1590/0074-02760190004
1678-8060
url https://www.arca.fiocruz.br/handle/icict/33446
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33446/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/33446/2/Association%20between%20MBL2_Marcelo_Ribeiro-Alves_INI_Lapclin-AIDS_2019.pdf
https://www.arca.fiocruz.br/bitstream/icict/33446/3/Association%20between%20MBL2_Marcelo_Ribeiro-Alves_INI_Lapclin-AIDS_2019.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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