Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods

Detalhes bibliográficos
Autor(a) principal: Carneiro, Megmar A. S.
Data de Publicação: 2001
Outros Autores: Martins, Regina M. B., Teles, Sheila A., Silva, Simonne A, Lopes, Carmen L., Cardoso, Divina D. P., Vanderborght, Bart O. M., Yoshida, Clara F. T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44146
Resumo: Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Virologia. Goiânia, Go, Brasil.
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spelling Carneiro, Megmar A. S.Martins, Regina M. B.Teles, Sheila A.Silva, Simonne A,Lopes, Carmen L.Cardoso, Divina D. P.Vanderborght, Bart O. M.Yoshida, Clara F. T.2020-10-23T14:04:16Z2020-10-23T14:04:16Z2001CARNEIRO, Megmar A. S. et al. Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 6, p. 765-769, Aug. 2001.0074-0276https://www.arca.fiocruz.br/handle/icict/4414610.1590/S0074-027620010006000031678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Hepatite CHemodiálisePrevalênciaFatores de riscoBrasil CentralHepatitis CHemodialysisPrevalenceRIsk factorsCentral BrazilHepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methodsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Virologia. Goiânia, Go, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Virologia. Goiânia, Go, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Virologia. Goiânia, Go, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Virologia. Goiânia, Go, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Virologia. Goiânia, Go, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Virologia. Goiânia, Go, Brasil.Innogenetics N.V.. Ghent, Belgium / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia. Rio de Janeiro, RJ, Brasil.An hemodialysis population in Central Brazil was screened by polymerase chain reaction (PCR) and serological methods to assess the prevalence of hepatitis C virus (HCV) infection and to investigate associated risk factors. All hemodialysis patients (n=428) were interviewed in eight dialysis units in Goiânia city. Blood samples were collected and serum samples screened for anti-HCV antibodies by an enzyme-linked immunosorbent assay (ELISA). Positive samples were retested for confirmation with a line immunoassay (LIA). All samples were also tested for HCV RNA by the PCR. An overall prevalence of 46.7% (CI 95%: 42-51.5) was found, ranging from 20.7% (CI 95%: 8.8-38.1) to 90.4% (CI 95%: 79.9-96.4) depending on the dialysis unit. Of the 428 patients, 185 were found to be seropositive by ELISA, and 167 were confirmed positive by LIA, resulting in an anti-HCV prevalence of 39%. A total of 131 patients were HCV RNA-positive. HCV viremia was present in 63.5% of the anti-HCV-positive patients and in 10.3% of the anti-HCV-negative patients. Univariate analysis of risk factors showed that the number of previous blood transfusions, transfusion of blood before mandatory screening for antiHCV, length of time on hemodialysis, and treatment in multiple units were associated with HCV positivity. However, multivariate analysis revealed that blood transfusion before screening for anti-HCV and length of time on hemodialysis were significantly associated with HCV infection in this population. These data suggest that nosocomial transmission may play a role in the spread of HCV in the dialysis units studied. In addition to anti-HCV screening, HCV RNA detection is necessary for the diagnosis of HCV infection in hemodialysis patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44146/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClaraFT_Yoshida_etal_IOC_2001.pdfClaraFT_Yoshida_etal_IOC_2001.pdfapplication/pdf47494https://www.arca.fiocruz.br/bitstream/icict/44146/2/ClaraFT_Yoshida_etal_IOC_2001.pdfc98ad5a9aab49e806ba80bc4065a88d7MD52TEXTClaraFT_Yoshida_etal_IOC_2001.pdf.txtClaraFT_Yoshida_etal_IOC_2001.pdf.txtExtracted texttext/plain20800https://www.arca.fiocruz.br/bitstream/icict/44146/3/ClaraFT_Yoshida_etal_IOC_2001.pdf.txt5e6122d7dce2976f0aa291f7c978b26cMD53icict/441462020-10-24 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dc.title.pt_BR.fl_str_mv Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods
title Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods
spellingShingle Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods
Carneiro, Megmar A. S.
Hepatite C
Hemodiálise
Prevalência
Fatores de risco
Brasil Central
Hepatitis C
Hemodialysis
Prevalence
RIsk factors
Central Brazil
title_short Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods
title_full Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods
title_fullStr Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods
title_full_unstemmed Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods
title_sort Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods
author Carneiro, Megmar A. S.
author_facet Carneiro, Megmar A. S.
Martins, Regina M. B.
Teles, Sheila A.
Silva, Simonne A,
Lopes, Carmen L.
Cardoso, Divina D. P.
Vanderborght, Bart O. M.
Yoshida, Clara F. T.
author_role author
author2 Martins, Regina M. B.
Teles, Sheila A.
Silva, Simonne A,
Lopes, Carmen L.
Cardoso, Divina D. P.
Vanderborght, Bart O. M.
Yoshida, Clara F. T.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carneiro, Megmar A. S.
Martins, Regina M. B.
Teles, Sheila A.
Silva, Simonne A,
Lopes, Carmen L.
Cardoso, Divina D. P.
Vanderborght, Bart O. M.
Yoshida, Clara F. T.
dc.subject.other.pt_BR.fl_str_mv Hepatite C
Hemodiálise
Prevalência
Fatores de risco
Brasil Central
topic Hepatite C
Hemodiálise
Prevalência
Fatores de risco
Brasil Central
Hepatitis C
Hemodialysis
Prevalence
RIsk factors
Central Brazil
dc.subject.en.pt_BR.fl_str_mv Hepatitis C
Hemodialysis
Prevalence
RIsk factors
Central Brazil
description Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Virologia. Goiânia, Go, Brasil.
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2020-10-23T14:04:16Z
dc.date.available.fl_str_mv 2020-10-23T14:04:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CARNEIRO, Megmar A. S. et al. Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 6, p. 765-769, Aug. 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44146
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762001000600003
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv CARNEIRO, Megmar A. S. et al. Hepatitis C Prevalence and Risk Factors in Hemodialysis Patients in Central Brazil: a Survey by Polymerase Chain Reaction and Serological Methods. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 6, p. 765-769, Aug. 2001.
0074-0276
10.1590/S0074-02762001000600003
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44146
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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