Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells

Detalhes bibliográficos
Autor(a) principal: O'Hare, Joselli Silva
Data de Publicação: 2016
Outros Autores: Oliveira, Isabela Silva de, Klevorn, Thaís, Almeida, Valter dos Anjos, Oliveira, Geraldo Gileno de Sá, Atta, Ajax Mercês, Freitas, Luiz Antonio Rodrigues de, dosSantos, Washington Luis Conrado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17768
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia (Fapesb). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes) and Fundação Oswaldo Cruz (Fiocruz).
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spelling O'Hare, Joselli SilvaOliveira, Isabela Silva deKlevorn, ThaísAlmeida, Valter dos AnjosOliveira, Geraldo Gileno de SáAtta, Ajax MercêsFreitas, Luiz Antonio Rodrigues dedosSantos, Washington Luis Conrado2017-02-09T13:47:07Z2017-02-09T13:47:07Z2016O'HARE, J. S. et al. Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells. Plos One, v. 11, n. 5, p. e0156733, 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1776810.1371/journal.pone.0156733Fundação de Amparo à Pesquisa do Estado da Bahia (Fapesb). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes) and Fundação Oswaldo Cruz (Fiocruz).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilVisceral leishmaniasis (VL) is a disease caused by Leishmania infantum, which is transmitted by phlebotomine sandflies. Dogs are the main urban reservoir of this parasite and the disease presents similar characteristics in both humans and dogs. In this paper, we investigated the potential pathways involved in plasma cell replacement of normal cell populations in the spleen, with respect to disease severity in dogs from an endemic area for visceral leishmaniasis. To this end, canine spleen samples were grouped into three categories: TYPE1SC- (non-infected dogs or without active infection with organized white pulp), TYPE1SC+ (infected dogs with organized white pulp) or TYPE3SC+ (infected animals with disorganized white pulp). We analyzed the distribution of different plasma cell isotypes (IgA, IgG and IgM) in the spleen. The expression of cytokines and chemokines involved in plasma cell homing and survival were assessed by real time RT-PCR. Polyclonal B cell activation and hypergammaglobulinemia were also evaluated. The proportion of animals with moderate or intense plasmacytosis was higher in the TYPE3SC+ group than in the other groups (Fisher test, P<0.05). This was mainly due to a higher density of IgG+ plasma cells in the red pulp of this group. The albumin/globulin ratio was lower in the TYPE3SC+ animals than in the TYPE1SC- or TYPE1SC+ animals, which evidences VL-associated dysproteinemia. Interestingly, TYPE3SC+ animals showed increased expression of the BAFF and APRIL cytokines, as well as chemokine CXCL12. Aberrant expression of BAFF, APRIL and CXCL12, together with amplified extrafollicular B cell activation, lead to plasma cell homing and the extended survival of these cells in the splenic red pulp compartment. These changes in the distribution of immunocompetent cells in the spleen may contribute to the progression of VL, and impair the spleen's ability to protect against blood borne pathogens.engPublic Library of ScienceLeishmaniose VisceralLeishmania infantumPhlebotomoAnimalCãesTecido linfoideCélulas plasmáticasLeishmaniose VisceralLeishmania infantumPhlebotomusAnimalDogsLymphoid TissuePlasma CellsDisruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17768/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALO'Hare JS Disruption of splenic....pdfO'Hare JS Disruption of 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dc.title.pt_BR.fl_str_mv Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells
title Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells
spellingShingle Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells
O'Hare, Joselli Silva
Leishmaniose Visceral
Leishmania infantum
Phlebotomo
Animal
Cães
Tecido linfoide
Células plasmáticas
Leishmaniose Visceral
Leishmania infantum
Phlebotomus
Animal
Dogs
Lymphoid Tissue
Plasma Cells
title_short Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells
title_full Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells
title_fullStr Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells
title_full_unstemmed Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells
title_sort Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells
author O'Hare, Joselli Silva
author_facet O'Hare, Joselli Silva
Oliveira, Isabela Silva de
Klevorn, Thaís
Almeida, Valter dos Anjos
Oliveira, Geraldo Gileno de Sá
Atta, Ajax Mercês
Freitas, Luiz Antonio Rodrigues de
dosSantos, Washington Luis Conrado
author_role author
author2 Oliveira, Isabela Silva de
Klevorn, Thaís
Almeida, Valter dos Anjos
Oliveira, Geraldo Gileno de Sá
Atta, Ajax Mercês
Freitas, Luiz Antonio Rodrigues de
dosSantos, Washington Luis Conrado
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv O'Hare, Joselli Silva
Oliveira, Isabela Silva de
Klevorn, Thaís
Almeida, Valter dos Anjos
Oliveira, Geraldo Gileno de Sá
Atta, Ajax Mercês
Freitas, Luiz Antonio Rodrigues de
dosSantos, Washington Luis Conrado
dc.subject.other.pt_BR.fl_str_mv Leishmaniose Visceral
Leishmania infantum
Phlebotomo
Animal
Cães
Tecido linfoide
Células plasmáticas
topic Leishmaniose Visceral
Leishmania infantum
Phlebotomo
Animal
Cães
Tecido linfoide
Células plasmáticas
Leishmaniose Visceral
Leishmania infantum
Phlebotomus
Animal
Dogs
Lymphoid Tissue
Plasma Cells
dc.subject.en.pt_BR.fl_str_mv Leishmaniose Visceral
Leishmania infantum
Phlebotomus
Animal
Dogs
Lymphoid Tissue
Plasma Cells
description Fundação de Amparo à Pesquisa do Estado da Bahia (Fapesb). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes) and Fundação Oswaldo Cruz (Fiocruz).
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-02-09T13:47:07Z
dc.date.available.fl_str_mv 2017-02-09T13:47:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv O'HARE, J. S. et al. Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells. Plos One, v. 11, n. 5, p. e0156733, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17768
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0156733
identifier_str_mv O'HARE, J. S. et al. Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells. Plos One, v. 11, n. 5, p. e0156733, 2016.
1932-6203
10.1371/journal.pone.0156733
url https://www.arca.fiocruz.br/handle/icict/17768
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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