Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/60658 |
Resumo: | Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/ Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil. |
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Alves-Hanna, Fabíola SilvaCrespo-Neto, Juniel AssisNogueira, Glenda MenezesPereira, Daniele SáLima, Amanda BarrosRibeiro, Thaís Lohana PereiraSantos, Vitória Giovanna RodriguesFonseca, Joey Ramone FerreiraMagalhães-Gama, FábioSadahiro, AyaCosta, Allyson Guimarães2023-10-03T11:41:12Z2023-10-03T11:41:12Z2023ALVES-HANNA, Fabíola Silva et al. Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? Journal of Immunology Research, v. 2023, 5584492. doi: 10.1155/2023/5584492.2314-7156https://www.arca.fiocruz.br/handle/icict/60658engHindawi Publishing CorporationInsights Regarding the Role of Inflammasomes in Leukemia: What Do We Know?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/ Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, Brazil.Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/ Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte, MG, Brazil.Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil.Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, Brazil/ Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte, MG, Brazil/Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brazil.Inflammation is a physiological mechanism of the immune response and has an important role in maintaining the hematopoietic cell niche in the bone marrow. During this process, the participation of molecules produced by innate immunity cells in response to a variety of pathogen-associated molecular patterns and damage-associated molecular patterns is observed. However, chronic inflammation is intrinsically associated with leukemogenesis, as it induces DNA damage in hematopoietic stem cells and contributes to the creation of the preleukemic clone. Several factors influence the malignant transformation within the hematopoietic microenvironment, with inflammasomes having a crucial role in this process, in addition to acting in the regulation of hematopoiesis and its homeostasis. Inflammasomes are intracellular multimeric complexes responsible for the maturation and secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and the cell death process via pyroptosis. Therefore, dysregulation of the activation of these complexes may be a factor in triggering several diseases, including leukemias, and this has been the subject of several studies in the area. In this review, we summarized the current knowledge on the relationship between inflammation and leukemogenesis, in particular, the role of inflammasomes in different types of leukemias, and we describe the potential therapeutic targets directed at inflammasomes in the leukemic contextinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60658/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALInsights Regarding the Role of Inflammasomes in Leukemia_ What Do We Know_.pdfInsights Regarding the Role of Inflammasomes in Leukemia_ What Do We Know_.pdfapplication/pdf1391242https://www.arca.fiocruz.br/bitstream/icict/60658/2/Insights%20Regarding%20the%20Role%20of%20Inflammasomes%20in%20Leukemia_%20What%20Do%20We%20Know_.pdfc0c3c9f3b760db08b20e82350426bd1fMD52icict/606582023-10-03 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| dc.title.en_US.fl_str_mv |
Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| title |
Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| spellingShingle |
Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? Alves-Hanna, Fabíola Silva |
| title_short |
Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| title_full |
Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| title_fullStr |
Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| title_full_unstemmed |
Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| title_sort |
Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| author |
Alves-Hanna, Fabíola Silva |
| author_facet |
Alves-Hanna, Fabíola Silva Crespo-Neto, Juniel Assis Nogueira, Glenda Menezes Pereira, Daniele Sá Lima, Amanda Barros Ribeiro, Thaís Lohana Pereira Santos, Vitória Giovanna Rodrigues Fonseca, Joey Ramone Ferreira Magalhães-Gama, Fábio Sadahiro, Aya Costa, Allyson Guimarães |
| author_role |
author |
| author2 |
Crespo-Neto, Juniel Assis Nogueira, Glenda Menezes Pereira, Daniele Sá Lima, Amanda Barros Ribeiro, Thaís Lohana Pereira Santos, Vitória Giovanna Rodrigues Fonseca, Joey Ramone Ferreira Magalhães-Gama, Fábio Sadahiro, Aya Costa, Allyson Guimarães |
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author author author author author author author author author author |
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Alves-Hanna, Fabíola Silva Crespo-Neto, Juniel Assis Nogueira, Glenda Menezes Pereira, Daniele Sá Lima, Amanda Barros Ribeiro, Thaís Lohana Pereira Santos, Vitória Giovanna Rodrigues Fonseca, Joey Ramone Ferreira Magalhães-Gama, Fábio Sadahiro, Aya Costa, Allyson Guimarães |
| description |
Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/ Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil. |
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ALVES-HANNA, Fabíola Silva et al. Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? Journal of Immunology Research, v. 2023, 5584492. doi: 10.1155/2023/5584492. |
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ALVES-HANNA, Fabíola Silva et al. Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? Journal of Immunology Research, v. 2023, 5584492. doi: 10.1155/2023/5584492. 2314-7156 |
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