Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela

Morales, Ivonne; Rosenberger, Kerstin D.; Magalhaes, Tereza; Morais, Clarice N. L.; Braga, Cynthia; Marques, Ernesto T. A.; Calvet, Guilherme Amaral; Damasceno, Luana; Brasil, Patricia; Filippis, Ana Maria Bispo de; Tami, Adriana; Bethencourt, Sarah; Alvarez, Mayling; Martínez, Pedro A.; Guzman, Maria G.; Benevides, Bruno Souza; Caprara, Andrea; Quyen, Nguyen Than Ha; Simmons, Cameron P.; Wills, Bridget; Lamballerie, Xavier de; Drexler, Jan Felix; Jaenisch, Thomas; IDAMS Clinical Study Group

Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela

Detalhes bibliográficos
Autor(a) principal:	Morales, Ivonne
Data de Publicação:	2021
Outros Autores:	Rosenberger, Kerstin D., Magalhaes, Tereza, Morais, Clarice N. L., Braga, Cynthia, Marques, Ernesto T. A., Calvet, Guilherme Amaral, Damasceno, Luana, Brasil, Patricia, Filippis, Ana Maria Bispo de, Tami, Adriana, Bethencourt, Sarah, Alvarez, Mayling, Martínez, Pedro A., Guzman, Maria G., Benevides, Bruno Souza, Caprara, Andrea, Quyen, Nguyen Than Ha, Simmons, Cameron P., Wills, Bridget, Lamballerie, Xavier de, Drexler, Jan Felix, Jaenisch, Thomas, IDAMS Clinical Study Group
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/47856
Resumo:	Heidelberg University Hospital. Department for Infectious Diseases. Section Clinical Tropical Medicine. Heidelberg, Germany / Associated partner Heidelberg University Hospital. German Centre for Infection Research. Heidelberg, Germany.

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Morales, IvonneRosenberger, Kerstin D.Magalhaes, TerezaMorais, Clarice N. L.Braga, CynthiaMarques, Ernesto T. A.Calvet, Guilherme AmaralDamasceno, LuanaBrasil, PatriciaFilippis, Ana Maria Bispo deTami, AdrianaBethencourt, SarahAlvarez, MaylingMartínez, Pedro A.Guzman, Maria G.Benevides, Bruno SouzaCaprara, AndreaQuyen, Nguyen Than HaSimmons, Cameron P.Wills, BridgetLamballerie, Xavier deDrexler, Jan FelixJaenisch, ThomasIDAMS Clinical Study Group2021-06-24T13:46:39Z2021-06-24T13:46:39Z2021MORALES, Ivonne et al. Diagnostic performance of anti-Zika virus IgM, IgAM and IgG ELISAs during co-circulation of Zika, dengue, and chikungunya viruses in Brazil and Venezuela. PLoS neglected tropical diseases, v. 15, n. 4, p. 1-19, 20211935-2727https://www.arca.fiocruz.br/handle/icict/4785610.1371/journal.pntd.0009336engPublic Library of ScienceDiagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuelainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHeidelberg University Hospital. Department for Infectious Diseases. Section Clinical Tropical Medicine. Heidelberg, Germany / Associated partner Heidelberg University Hospital. German Centre for Infection Research. Heidelberg, Germany.Heidelberg University Hospital. Department for Infectious Diseases. Section Clinical Tropical Medicine. Heidelberg, Germany / Associated partner Heidelberg University Hospital. German Centre for Infection Research. Heidelberg, Germany.Colorado State University. Department of Microbiology, Immunology and Pathology. Center for Vector-Borne Infectious Diseases. Fort Collins, Colorado, United States of America.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapêutica Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil / Instituto de Medicina Integral Professor Fernando Figueira. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapêutica Experimental. Recife, PE, Brasil / University of Pittsburgh. Graduate School of Public Health. Department of Infectious Diseases. Pittsburgh, Pennsylvania, United States of America.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil.University of Groningen. University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention. Groningen, The Netherlands / Universidad de Carabobo. Facultad de Ciencias de la Salud. Valencia, Venezuela.Universidad de Carabobo. Facultad de Ciencias de la Salud. Valencia, Venezuela.Instituto de Medicina Tropical Pedro Kouri. La Habana, Cuba.Instituto de Medicina Tropical Pedro Kouri. La Habana, Cuba.Instituto de Medicina Tropical Pedro Kouri. La Habana, Cuba.Universidade Estadual do Ceará. Fortaleza, CE, Brasil.Universidade Estadual do Ceará. Fortaleza, CE, Brasil.Oxford University Clinical Research Unit. Hospital for Tropical Diseases. Ho Chi Minh City, Vietnam.Oxford University Clinical Research Unit. Hospital for Tropical Diseases. Ho Chi Minh City, Vietnam / Monash University. Institute for Vector-Borne Disease. Melbourne, Australia.Oxford University Clinical Research Unit. Hospital for Tropical Diseases. Ho Chi Minh City, Vietnam / Oxford University. Nuffield Department of Clinical Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom.Unité des Virus Emergents. Marseille, France.Humboldt-Universität zu Berlin. Charité-Universitätsmedizin Berlin. Institute of Virology. Berlin, Germany / Sechenov University. Martsinovsky Institute of Medical Parasitology. Tropical and Vector-Borne Diseases. Moscow, Russia / Universitätsmedizin Berlin. German Centre for Infection Research. Berlin, Germany.Background: Serological diagnosis of Zika virus (ZIKV) infection is challenging because of the antibody cross-reactivity among flaviviruses. At the same time, the role of Nucleic Acid Testing (NAT) is limited by the low proportion of symptomatic infections and the low average viral load. Here, we compared the diagnostic performance of commercially available IgM, IgAM, and IgG ELISAs in sequential samples during the ZIKV and chikungunya (CHIKV) epidemics and co-circulation of dengue virus (DENV) in Brazil and Venezuela. Methodology/principal findings: Acute (day of illness 1-5) and follow-up (day of illness ≥ 6) blood samples were collected from nine hundred and seven symptomatic patients enrolled in a prospective multicenter study between June 2012 and August 2016. Acute samples were tested by RT-PCR for ZIKV, DENV, and CHIKV. Acute and follow-up samples were tested for IgM, IgAM, and IgG antibodies to ZIKV using commercially available ELISAs. Among follow-up samples with a RT-PCR confirmed ZIKV infection, anti-ZIKV IgAM sensitivity was 93.5% (43/46), while IgM and IgG exhibited sensitivities of 30.3% (10/33) and 72% (18/25), respectively. An additional 24% (26/109) of ZIKV infections were detected via IgAM seroconversion in ZIKV/DENV/CHIKV RT-PCR negative patients. The specificity of anti-ZIKV IgM was estimated at 93% and that of IgAM at 85%. Conclusions/significance: Our findings exemplify the challenges of the assessment of test performance for ZIKV serological tests in the real-world setting, during co-circulation of DENV, ZIKV, and CHIKV. However, we can also demonstrate that the IgAM immunoassay exhibits superior sensitivity to detect ZIKV RT-PCR confirmed infections compared to IgG and IgM immunoassays. The IgAM assay also proves to be promising for detection of anti-ZIKV seroconversions in sequential samples, both in ZIKV PCR-positive as well as PCR-negative patients, making this a candidate assay for serological monitoring of pregnant women in future ZIKV outbreaks.Zika virusEnzyme-linked immunoassaysDengue virusChikungunya virusAntibodiesImmunoassaysSerologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv	Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela
title	Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela
spellingShingle	Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela Morales, Ivonne Zika virus Enzyme-linked immunoassays Dengue virus Chikungunya virus Antibodies Immunoassays Serology
title_short	Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela
title_full	Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela
title_fullStr	Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela
title_full_unstemmed	Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela
title_sort	Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela
author	Morales, Ivonne
author_facet	Morales, Ivonne Rosenberger, Kerstin D. Magalhaes, Tereza Morais, Clarice N. L. Braga, Cynthia Marques, Ernesto T. A. Calvet, Guilherme Amaral Damasceno, Luana Brasil, Patricia Filippis, Ana Maria Bispo de Tami, Adriana Bethencourt, Sarah Alvarez, Mayling Martínez, Pedro A. Guzman, Maria G. Benevides, Bruno Souza Caprara, Andrea Quyen, Nguyen Than Ha Simmons, Cameron P. Wills, Bridget Lamballerie, Xavier de Drexler, Jan Felix Jaenisch, Thomas IDAMS Clinical Study Group
author_role	author
author2	Rosenberger, Kerstin D. Magalhaes, Tereza Morais, Clarice N. L. Braga, Cynthia Marques, Ernesto T. A. Calvet, Guilherme Amaral Damasceno, Luana Brasil, Patricia Filippis, Ana Maria Bispo de Tami, Adriana Bethencourt, Sarah Alvarez, Mayling Martínez, Pedro A. Guzman, Maria G. Benevides, Bruno Souza Caprara, Andrea Quyen, Nguyen Than Ha Simmons, Cameron P. Wills, Bridget Lamballerie, Xavier de Drexler, Jan Felix Jaenisch, Thomas IDAMS Clinical Study Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Morales, Ivonne Rosenberger, Kerstin D. Magalhaes, Tereza Morais, Clarice N. L. Braga, Cynthia Marques, Ernesto T. A. Calvet, Guilherme Amaral Damasceno, Luana Brasil, Patricia Filippis, Ana Maria Bispo de Tami, Adriana Bethencourt, Sarah Alvarez, Mayling Martínez, Pedro A. Guzman, Maria G. Benevides, Bruno Souza Caprara, Andrea Quyen, Nguyen Than Ha Simmons, Cameron P. Wills, Bridget Lamballerie, Xavier de Drexler, Jan Felix Jaenisch, Thomas IDAMS Clinical Study Group
dc.subject.en.pt_BR.fl_str_mv	Zika virus Enzyme-linked immunoassays Dengue virus Chikungunya virus Antibodies Immunoassays Serology
topic	Zika virus Enzyme-linked immunoassays Dengue virus Chikungunya virus Antibodies Immunoassays Serology
description	Heidelberg University Hospital. Department for Infectious Diseases. Section Clinical Tropical Medicine. Heidelberg, Germany / Associated partner Heidelberg University Hospital. German Centre for Infection Research. Heidelberg, Germany.
publishDate	2021
dc.date.accessioned.fl_str_mv	2021-06-24T13:46:39Z
dc.date.available.fl_str_mv	2021-06-24T13:46:39Z
dc.date.issued.fl_str_mv	2021
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	MORALES, Ivonne et al. Diagnostic performance of anti-Zika virus IgM, IgAM and IgG ELISAs during co-circulation of Zika, dengue, and chikungunya viruses in Brazil and Venezuela. PLoS neglected tropical diseases, v. 15, n. 4, p. 1-19, 2021
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/47856
dc.identifier.issn.pt_BR.fl_str_mv	1935-2727
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pntd.0009336
identifier_str_mv	MORALES, Ivonne et al. Diagnostic performance of anti-Zika virus IgM, IgAM and IgG ELISAs during co-circulation of Zika, dengue, and chikungunya viruses in Brazil and Venezuela. PLoS neglected tropical diseases, v. 15, n. 4, p. 1-19, 2021 1935-2727 10.1371/journal.pntd.0009336
url	https://www.arca.fiocruz.br/handle/icict/47856
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/47856/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/47856/2/Diagnostic_Guilherme_Calvet_etal_INI_2021.pdf https://www.arca.fiocruz.br/bitstream/icict/47856/3/Diagnostic_Guilherme_Calvet_etal_INI_2021.pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Diagnostic performance of anti-zika virus igm, igam and igg elisas during co-circulation of zika, dengue, and chikungunya viruses in brazil and venezuela

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