Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole

Detalhes bibliográficos
Autor(a) principal: Gremião, I. D.
Data de Publicação: 2011
Outros Autores: Schubach, T. M. P., Pereira, S. A., Rodrigues, A., Honse, C., Barros, M. B. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33203
Resumo: 2020-05-24
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spelling Gremião, I. D.Schubach, T. M. P.Pereira, S. A.Rodrigues, A.Honse, C.Barros, M. B. L.2019-05-24T12:29:33Z2019-05-24T12:29:33Z2011GREMIÃO, I. D. et al. Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole. Australian Veterinary Journal, v. 89, n. 9, p. 346-351, 2011.0005-0423https://www.arca.fiocruz.br/handle/icict/3320310.1111/j.1751-0813.2011.00804.x1751-0813engWileyTreatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazoleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-05-24Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Objective: To describe the use of intralesional amphotericin B inlocalised lesions for the treatment of 26 cats from Rio de Janeiro, Brazil, with sporotrichosis refractory to oral itraconazole. Design: Uncontrolled intervention study. Method: The 26 cats in this study were diagnosed with sporotri-chosis, confirmed by isolation of Sporothrix schenckii, and presented residual localised skin lesions refractory to treatment with oral itraconazole for a minimum period of 8 weeks. The animals received weekly applications of intralesional amphotericin B in conjunction with oral itraconazole. In cases of owner unavailability, a maximumof 2 weeks between the infiltrations was accepted. Results: Twenty-two (84.6%) of the 26 treated cats achieved clini-cal remission, 16 (72.7%) of which were cured, and in the remainingsix (27.3%) the lesions recurred at the same site. Lack of clinical response was observed in one animal and three owners abandonedtreatment. Conclusion: The proposed therapeutic regimen is an adjunctive treatment option for cats with sporotrichosis presenting as residualskin lesions refractory to itraconazole.Amphotericin BCatsIntralesional therapyItraconazoleSporotrichosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/33203/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Gremião_I_etal_INI_2011.pdfve_Gremião_I_etal_INI_2011.pdfapplication/pdf781998https://www.arca.fiocruz.br/bitstream/icict/33203/2/ve_Gremi%c3%a3o_I_etal_INI_2011.pdf81ac03d39d482dad67d2dbbd82646494MD52TEXTve_Gremião_I_etal_INI_2011.pdf.txtve_Gremião_I_etal_INI_2011.pdf.txtExtracted texttext/plain31211https://www.arca.fiocruz.br/bitstream/icict/33203/3/ve_Gremi%c3%a3o_I_etal_INI_2011.pdf.txt6fef256ca0979831cccc41f6f1d78eb5MD53icict/332032021-03-24 16:32:32.224oai:www.arca.fiocruz.br:icict/33203Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole
title Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole
spellingShingle Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole
Gremião, I. D.
Amphotericin B
Cats
Intralesional therapy
Itraconazole
Sporotrichosis
title_short Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole
title_full Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole
title_fullStr Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole
title_full_unstemmed Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole
title_sort Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole
author Gremião, I. D.
author_facet Gremião, I. D.
Schubach, T. M. P.
Pereira, S. A.
Rodrigues, A.
Honse, C.
Barros, M. B. L.
author_role author
author2 Schubach, T. M. P.
Pereira, S. A.
Rodrigues, A.
Honse, C.
Barros, M. B. L.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Gremião, I. D.
Schubach, T. M. P.
Pereira, S. A.
Rodrigues, A.
Honse, C.
Barros, M. B. L.
dc.subject.en.pt_BR.fl_str_mv Amphotericin B
Cats
Intralesional therapy
Itraconazole
Sporotrichosis
topic Amphotericin B
Cats
Intralesional therapy
Itraconazole
Sporotrichosis
description 2020-05-24
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2019-05-24T12:29:33Z
dc.date.available.fl_str_mv 2019-05-24T12:29:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv GREMIÃO, I. D. et al. Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole. Australian Veterinary Journal, v. 89, n. 9, p. 346-351, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33203
dc.identifier.issn.pt_BR.fl_str_mv 0005-0423
dc.identifier.doi.none.fl_str_mv 10.1111/j.1751-0813.2011.00804.x
dc.identifier.eissn.none.fl_str_mv 1751-0813
identifier_str_mv GREMIÃO, I. D. et al. Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole. Australian Veterinary Journal, v. 89, n. 9, p. 346-351, 2011.
0005-0423
10.1111/j.1751-0813.2011.00804.x
1751-0813
url https://www.arca.fiocruz.br/handle/icict/33203
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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