Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection

Detalhes bibliográficos
Autor(a) principal: Araújo, Flávio Marcos Gomes
Data de Publicação: 2008
Outros Autores: Sonoda, Ivan Vieira, Rodrigues, Nilton Barnabé, Teixeira, Rosângela, Redondo, Rodrigo A. F., Oliveira, Guilherme Corrêa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6643
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
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spelling Araújo, Flávio Marcos GomesSonoda, Ivan VieiraRodrigues, Nilton BarnabéTeixeira, RosângelaRedondo, Rodrigo A. F.Oliveira, Guilherme Corrêa de2013-07-03T18:27:33Z2013-07-03T18:27:33Z2008ARAÚJO, Flávio Marcos Gomes et al. Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection. Mem Inst Oswaldo Cruz. 2008;103(6):611-4.https://www.arca.fiocruz.br/handle/icict/6643S0074-02762008000600018engGenetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilHospital das Clínicas. Instituto Alfa de GastroenterologiaUniversidade Federal de Minas Gerais. Instituto de Ciencias Biológicas. Laboratório de Biodiversidade e Evolução Molecular Departamento de Biologia Geral. Belo Horizonte, MG, BrasilSanta Casa de Belo Horizonte. Programa de Pós-Graduação e Pesquisa. Belo Horizonte, MG, BrasilSequence variation among different hepatitis C virus (HCV) isolates has adaptive significance and reflects the modes and intensities of selection mechanisms operating on the virus. In this work, we sought to investigate using classical population genetics parameters, the genetic variability of HCV genotype 1 using the 5' UTR and NS5A regions from treatment non-responding and responding groups of patients. Both regions showed low genetic varia-bility and the 5' UTR showed neutral deviation. No differences were observed in the nonsynonymous/synonymous nucleotide substitution ratio among groups for NS5A. The analysis of molecular variance test of the 5' UTR region showed an 11.94% variation among groups. Phylogenetic analysis showed no correlation between sequence variations and therapeutic responseshepatitis Cvirus 5'UTRNS5Atherapeuticinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL8. ARAUJO FMG, SONODA IV.pdf8. ARAUJO FMG, SONODA IV.pdfapplication/pdf390202https://www.arca.fiocruz.br/bitstream/icict/6643/1/8.%20ARAUJO%20FMG%2c%20SONODA%20IV.pdf12579764f3ec1d032cea575fc9365b80MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6643/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXT8. ARAUJO FMG, SONODA IV.pdf.txt8. ARAUJO FMG, SONODA IV.pdf.txtExtracted texttext/plain21212https://www.arca.fiocruz.br/bitstream/icict/6643/5/8.%20ARAUJO%20FMG%2c%20SONODA%20IV.pdf.txt5379e23591dd90ca84936638d9512b08MD55THUMBNAIL8. 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dc.title.pt_BR.fl_str_mv Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection
title Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection
spellingShingle Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection
Araújo, Flávio Marcos Gomes
hepatitis C
virus 5'
UTR
NS5A
therapeutic
title_short Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection
title_full Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection
title_fullStr Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection
title_full_unstemmed Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection
title_sort Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection
author Araújo, Flávio Marcos Gomes
author_facet Araújo, Flávio Marcos Gomes
Sonoda, Ivan Vieira
Rodrigues, Nilton Barnabé
Teixeira, Rosângela
Redondo, Rodrigo A. F.
Oliveira, Guilherme Corrêa de
author_role author
author2 Sonoda, Ivan Vieira
Rodrigues, Nilton Barnabé
Teixeira, Rosângela
Redondo, Rodrigo A. F.
Oliveira, Guilherme Corrêa de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo, Flávio Marcos Gomes
Sonoda, Ivan Vieira
Rodrigues, Nilton Barnabé
Teixeira, Rosângela
Redondo, Rodrigo A. F.
Oliveira, Guilherme Corrêa de
dc.subject.en.pt_BR.fl_str_mv hepatitis C
virus 5'
UTR
NS5A
therapeutic
topic hepatitis C
virus 5'
UTR
NS5A
therapeutic
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-07-03T18:27:33Z
dc.date.available.fl_str_mv 2013-07-03T18:27:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAÚJO, Flávio Marcos Gomes et al. Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection. Mem Inst Oswaldo Cruz. 2008;103(6):611-4.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6643
dc.identifier.doi.none.fl_str_mv S0074-02762008000600018
identifier_str_mv ARAÚJO, Flávio Marcos Gomes et al. Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection. Mem Inst Oswaldo Cruz. 2008;103(6):611-4.
S0074-02762008000600018
url https://www.arca.fiocruz.br/handle/icict/6643
dc.language.iso.fl_str_mv eng
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